Cargando…

Effects of Isosakuranetin on Pharmacokinetic Changes of Tofacitinib in Rats with N-Dimethylnitrosamine-Induced Liver Cirrhosis

Tofacitinib, a Janus kinase 1 and 3 inhibitor, is used to treat rheumatoid arthritis. It is mainly metabolized by the cytochromes p450 (CYP) 3A1/2 and CYP2C11 in the liver. Chronic inflammation eventually leads to cirrhosis in patients with rheumatoid arthritis. Isosakuranetin (ISN), a component of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bae, Sung Hun, Choi, Hyeon Gyeom, Park, So Yeon, Chang, Sun-Young, Kim, Hyoungsu, Kim, So Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783783/ https://www.ncbi.nlm.nih.gov/pubmed/36559177 http://dx.doi.org/10.3390/pharmaceutics14122684

Ejemplares similares

Effects of Hyperlipidemia on the Pharmacokinetics of Tofacitinib, a JAK 1/3 Inhibitor, in Rats
por: Won, Jong Mun, et al.
Publicado: (2023)

Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats
por: Lee, Ji-Sang, et al.
Publicado: (2021)

Effects of Dextran Sulfate Sodium-Induced Ulcerative Colitis on the Disposition of Tofacitinib in Rats
por: Bae, Sung Hun, et al.
Publicado: (2022)

Slower Elimination of Tofacitinib in Acute Renal Failure Rat Models: Contribution of Hepatic Metabolism and Renal Excretion
por: Bae, Sung Hun, et al.
Publicado: (2020)

Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism
por: Lee, Ji Sang, et al.
Publicado: (2019)

Imidazole Antifungal Drugs Inhibit the Cell Proliferation and Invasion of Human Breast Cancer Cells
por: Bae, Sung Hun, et al.
Publicado: (2018)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) shows therapeutic effect on dimethylnitrosamine (DMN)-induced liver fibrosis in rats
por: Karmacharya, Mrigendra Bir, et al.
Publicado: (2022)

Induction of liver tumours in the rabbit by feeding dimethylnitrosamine.
por: Le Page, R. N., et al.
Publicado: (1969)

Bioequivalence of the pharmacokinetics between tofacitinib aspartate and tofacitinib citrate in healthy subjects
por: Shin, Wonsuk, et al.
Publicado: (2020)

Malignant Transformation in vitro of Rat Liver Cells by Dimethylnitrosamine and N-Methyl-N′-nitro-N-Nitrosoguanidine
por: Montesano, R., et al.
Publicado: (1973)

Protective effects of Centella asiatica leaf extract on dimethylnitrosamine-induced liver injury in rats
por: Choi, Myung-Joo, et al.
Publicado: (2016)

Carcinogenicity of dimethylnitrosamine in Swiss mice.
por: Terracini, B., et al.
Publicado: (1966)

Influence of resveratrol on liver fibrosis induced by dimethylnitrosamine in male rats
por: Abdu, Suzan B., et al.
Publicado: (2019)

Effects of Poncirin, a Citrus Flavonoid and Its Aglycone, Isosakuranetin, on the Gut Microbial Diversity and Metabolomics in Mice
por: Cao, Xuedan, et al.
Publicado: (2022)

Exploring the modulatory impact of isosakuranetin on Staphylococcus aureus: Inhibition of sortase A activity and α-haemolysin expression
por: Tian, Lili, et al.
Publicado: (2023)

Proceedings: Immunosuppressive activity of N-nitroso-N-methylurea (NMU) and dimethylnitrosamine (DMN).
por: Waynforth, H. B., et al.
Publicado: (1974)

The activation of dimethylnitrosamine (DMN) by yeast extracts.
por: Read, J.
Publicado: (1975)

Changes in the Fine Structure of Rat Liver Cells Brought about by Dimethylnitrosamine
por: Emmelot, P., et al.
Publicado: (1960)

Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats
por: Chen, Xiaorong, et al.
Publicado: (2012)

Effects of Fuzheng Huayu recipe on entecavir pharmacokinetics in normal and dimethylnitrosamine-induced hepatic fibrosis rats
por: Yang, Tao, et al.
Publicado: (2019)

Comparative Studies of the Hepatocarcinogen N,N-Dimethylnitrosamine in vivo: Reaction Sites in Rat Liver DNA and the Significance of their Relative Stabilities
por: O'Connor, P. J., et al.
Publicado: (1973)

Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymalstem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice
por: Xiang, Yan, et al.
Publicado: (2017)

A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model
por: Kim, Hyo-Seon, et al.
Publicado: (2016)

Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.
por: González-Cortazar, Manáses, et al.
Publicado: (2013)

Effects of Diabetes Mellitus on the Disposition of Tofacitinib, a Janus Kinase Inhibitor, in Rats
por: Gwak, Eun Hye, et al.
Publicado: (2020)

Effects of naringenin on the pharmacokinetics of tofacitinib in rats
por: Wang, Bo, et al.
Publicado: (2020)

Quantitative studies on the in vitro metabolic activation of dimethylnitrosamine by rat liver postmitochondrial supernatant.
por: Doolittle, D J, et al.
Publicado: (1984)

Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice
por: Xiang, Yan, et al.
Publicado: (2021)

The Methoxyflavonoid Isosakuranetin Suppresses UV-B-Induced Matrix Metalloproteinase-1 Expression and Collagen Degradation Relevant for Skin Photoaging
por: Jung, Hana, et al.
Publicado: (2016)

Phase 1 Dose‐Escalation Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Tofacitinib in Japanese Healthy Volunteers
por: Miyoshi, So, et al.
Publicado: (2019)

Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats
por: Shin, Mi-Ok, et al.
Publicado: (2010)

Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine.
por: Reznik, G., et al.
Publicado: (1976)

Population pharmacokinetics of tofacitinib in patients with psoriatic arthritis
por: Xie, Rujia, et al.
Publicado: (2019)

The Effect of N-Nitroso-N-Methylurea and N-Dimethylnitrosamine on Cell Mediated and Humoral Immune Responses in Rats and Mice
por: Waynforth, H. B., et al.
Publicado: (1974)

Hepatic pathology in rats on low dietary levels of dimethylnitrosamine.
por: Terracini, B., et al.
Publicado: (1967)

Ethyl Acetate Fraction of Amomum xanthioides Exerts Antihepatofibrotic Actions via the Regulation of Fibrogenic Cytokines in a Dimethylnitrosamine-Induced Rat Model
por: Lee, Sung-Bae, et al.
Publicado: (2016)

A liver DNA synthesis promoter induced in rat plasma by injection of dimethylnitrosamine (DMNA) or thioacetamide.
por: Díaz-Gil, J. J., et al.
Publicado: (1987)

Transformed liver cells obtained in culture from hepatectomized rats treated with dimethylnitrosamine (dMN).
por: Mondal, S.
Publicado: (1975)

Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow
por: Jayakumar Amirtharaj, G., et al.
Publicado: (2014)

Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
por: Chen, Yuxin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_v6oh52kevg6lu6f9hag9pt2j5t