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Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood–brain barrier (BBB). As mounting evidence suggests that the ultrastructure of the BBB is altered in individuals with ALS and in animal models of ALS...

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Detalles Bibliográficos
Autores principales:	Pan, Yijun, Kagawa, Yoshiteru, Sun, Jiaqi, Turner, Bradley J., Huang, Cheng, Shah, Anup D., Schittenhelm, Ralf B., Nicolazzo, Joseph A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783795/ https://www.ncbi.nlm.nih.gov/pubmed/36559296 http://dx.doi.org/10.3390/pharmaceutics14122803

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