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Bidirectional Functional Effects of Staphylococcus on Carcinogenesis

As a Gram-positive cocci existing in nature, Staphylococcus has a variety of species, such as Staphylococcus aureus and Staphylococcus epidermidis, etc. Growing evidence reveals that Staphylococcus is closely related to the occurrence and development of various cancers. On the one hand, cancer patie...

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Autores principales: Wei, Yuannan, Sandhu, Esha, Yang, Xi, Yang, Jie, Ren, Yuanyuan, Gao, Xingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783839/
https://www.ncbi.nlm.nih.gov/pubmed/36557606
http://dx.doi.org/10.3390/microorganisms10122353
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author Wei, Yuannan
Sandhu, Esha
Yang, Xi
Yang, Jie
Ren, Yuanyuan
Gao, Xingjie
author_facet Wei, Yuannan
Sandhu, Esha
Yang, Xi
Yang, Jie
Ren, Yuanyuan
Gao, Xingjie
author_sort Wei, Yuannan
collection PubMed
description As a Gram-positive cocci existing in nature, Staphylococcus has a variety of species, such as Staphylococcus aureus and Staphylococcus epidermidis, etc. Growing evidence reveals that Staphylococcus is closely related to the occurrence and development of various cancers. On the one hand, cancer patients are more likely to suffer from bacterial infection and antibiotic-resistant strain infection compared to healthy controls. On the other hand, there exists an association between staphylococcal infection and carcinogenesis. Staphylococcus often plays a pathogenic role and evades the host immune system through surface adhesion molecules, α-hemolysin, PVL (Panton-Valentine leukocidin), SEs (staphylococcal enterotoxins), SpA (staphylococcal protein A), TSST-1 (Toxic shock syndrom toxin-1) and other factors. Staphylococcal nucleases (SNases) are extracellular nucleases that serve as genomic markers for Staphylococcus aureus. Interestingly, a human homologue of SNases, SND1 (staphylococcal nuclease and Tudor domain-containing 1), has been recognized as an oncoprotein. This review is the first to summarize the reported basic and clinical evidence on staphylococci and neoplasms. Investigations on the correlation between Staphylococcus and the occurrence, development, diagnosis and treatment of breast, skin, oral, colon and other cancers, are made from the perspectives of various virulence factors and SND1.
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spelling pubmed-97838392022-12-24 Bidirectional Functional Effects of Staphylococcus on Carcinogenesis Wei, Yuannan Sandhu, Esha Yang, Xi Yang, Jie Ren, Yuanyuan Gao, Xingjie Microorganisms Review As a Gram-positive cocci existing in nature, Staphylococcus has a variety of species, such as Staphylococcus aureus and Staphylococcus epidermidis, etc. Growing evidence reveals that Staphylococcus is closely related to the occurrence and development of various cancers. On the one hand, cancer patients are more likely to suffer from bacterial infection and antibiotic-resistant strain infection compared to healthy controls. On the other hand, there exists an association between staphylococcal infection and carcinogenesis. Staphylococcus often plays a pathogenic role and evades the host immune system through surface adhesion molecules, α-hemolysin, PVL (Panton-Valentine leukocidin), SEs (staphylococcal enterotoxins), SpA (staphylococcal protein A), TSST-1 (Toxic shock syndrom toxin-1) and other factors. Staphylococcal nucleases (SNases) are extracellular nucleases that serve as genomic markers for Staphylococcus aureus. Interestingly, a human homologue of SNases, SND1 (staphylococcal nuclease and Tudor domain-containing 1), has been recognized as an oncoprotein. This review is the first to summarize the reported basic and clinical evidence on staphylococci and neoplasms. Investigations on the correlation between Staphylococcus and the occurrence, development, diagnosis and treatment of breast, skin, oral, colon and other cancers, are made from the perspectives of various virulence factors and SND1. MDPI 2022-11-28 /pmc/articles/PMC9783839/ /pubmed/36557606 http://dx.doi.org/10.3390/microorganisms10122353 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wei, Yuannan
Sandhu, Esha
Yang, Xi
Yang, Jie
Ren, Yuanyuan
Gao, Xingjie
Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
title Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
title_full Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
title_fullStr Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
title_full_unstemmed Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
title_short Bidirectional Functional Effects of Staphylococcus on Carcinogenesis
title_sort bidirectional functional effects of staphylococcus on carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783839/
https://www.ncbi.nlm.nih.gov/pubmed/36557606
http://dx.doi.org/10.3390/microorganisms10122353
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