Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data

β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We...

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Autores principales: Ferreras-Antolin, Laura, Borman, Andrew, Diederichs, Antonia, Warris, Adilia, Lehrnbecher, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783846/
https://www.ncbi.nlm.nih.gov/pubmed/36547595
http://dx.doi.org/10.3390/jof8121262
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author Ferreras-Antolin, Laura
Borman, Andrew
Diederichs, Antonia
Warris, Adilia
Lehrnbecher, Thomas
author_facet Ferreras-Antolin, Laura
Borman, Andrew
Diederichs, Antonia
Warris, Adilia
Lehrnbecher, Thomas
author_sort Ferreras-Antolin, Laura
collection PubMed
description β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We aimed to analyse the available data for the use of serum BDG in neonates and immunocompromised children and adolescents; as well as to understand the extent and characteristics of the use of BDG in children in Europe.
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spelling pubmed-97838462022-12-24 Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data Ferreras-Antolin, Laura Borman, Andrew Diederichs, Antonia Warris, Adilia Lehrnbecher, Thomas J Fungi (Basel) Review β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We aimed to analyse the available data for the use of serum BDG in neonates and immunocompromised children and adolescents; as well as to understand the extent and characteristics of the use of BDG in children in Europe. MDPI 2022-11-30 /pmc/articles/PMC9783846/ /pubmed/36547595 http://dx.doi.org/10.3390/jof8121262 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ferreras-Antolin, Laura
Borman, Andrew
Diederichs, Antonia
Warris, Adilia
Lehrnbecher, Thomas
Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data
title Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data
title_full Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data
title_fullStr Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data
title_full_unstemmed Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data
title_short Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data
title_sort serum beta-d-glucan in the diagnosis of invasive fungal disease in neonates, children and adolescents: a critical analysis of current data
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783846/
https://www.ncbi.nlm.nih.gov/pubmed/36547595
http://dx.doi.org/10.3390/jof8121262
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