New Solid Forms of Nitrofurantoin and 4-Aminopyridine Salt: Influence of Salt Hydration Level on Crystal Packing and Physicochemical Properties

The crystallization of the poorly soluble drug nitrofurantoin (NFT) with 4-aminopyridine (4AmPy) resulted in three multicomponent solid forms with different hydration levels: anhydrous salt [NFT+4AmPy] (1:1), salt monohydrate [NFT+4AmPy+H(2)O] (1:1:1), and salt tetrahydrate [NFT+4AmPy+H(2)O] (1:1:4)...

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Detalles Bibliográficos
Autores principales: Boycov, Denis E., Drozd, Ksenia V., Manin, Alex N., Churakov, Andrei V., Perlovich, German L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783863/
https://www.ncbi.nlm.nih.gov/pubmed/36558123
http://dx.doi.org/10.3390/molecules27248990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783863/
https://www.ncbi.nlm.nih.gov/pubmed/36558123
http://dx.doi.org/10.3390/molecules27248990

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