Cargando…
Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review
Parkinson disease (PD) is a progressive, neurodegenerative disease of the central nervous system. Visual disturbance is one of the most frequent nonmotor abnormalities referred to by patients suffering from PD at early stages. Furthermore, ocular surface alterations including mainly dry eye and blin...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783883/ https://www.ncbi.nlm.nih.gov/pubmed/36556506 http://dx.doi.org/10.3390/life12122141 |
_version_ | 1784857679520333824 |
---|---|
author | Buzzi, Matilde Giannaccare, Giuseppe Cennamo, Michela Bernabei, Federico Rothschild, Pierre-Raphael Vagge, Aldo Scorcia, Vincenzo Mencucci, Rita |
author_facet | Buzzi, Matilde Giannaccare, Giuseppe Cennamo, Michela Bernabei, Federico Rothschild, Pierre-Raphael Vagge, Aldo Scorcia, Vincenzo Mencucci, Rita |
author_sort | Buzzi, Matilde |
collection | PubMed |
description | Parkinson disease (PD) is a progressive, neurodegenerative disease of the central nervous system. Visual disturbance is one of the most frequent nonmotor abnormalities referred to by patients suffering from PD at early stages. Furthermore, ocular surface alterations including mainly dry eye and blink reduction represent another common finding in patients with PD. Tears of PD patients show specific alterations related to protein composition, and in vivo confocal microscopy has demonstrated profound changes in different corneal layers in this setting. These changes can be attributed not only to the disease itself, but also to the medications used for its management. In particular, signs of corneal toxicity, both at epithelial and endothelial level, are well described in the literature in PD patients receiving amantadine. Management of PD patients from the ophthalmologist’s side requires knowledge of the common, but often underdiagnosed, ocular surface alterations as well as of the signs of drug toxicity. Furthermore, ocular surface biomarkers can be useful for the early diagnosis of PD as well as for monitoring the degree of neural degeneration over time. |
format | Online Article Text |
id | pubmed-9783883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97838832022-12-24 Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review Buzzi, Matilde Giannaccare, Giuseppe Cennamo, Michela Bernabei, Federico Rothschild, Pierre-Raphael Vagge, Aldo Scorcia, Vincenzo Mencucci, Rita Life (Basel) Review Parkinson disease (PD) is a progressive, neurodegenerative disease of the central nervous system. Visual disturbance is one of the most frequent nonmotor abnormalities referred to by patients suffering from PD at early stages. Furthermore, ocular surface alterations including mainly dry eye and blink reduction represent another common finding in patients with PD. Tears of PD patients show specific alterations related to protein composition, and in vivo confocal microscopy has demonstrated profound changes in different corneal layers in this setting. These changes can be attributed not only to the disease itself, but also to the medications used for its management. In particular, signs of corneal toxicity, both at epithelial and endothelial level, are well described in the literature in PD patients receiving amantadine. Management of PD patients from the ophthalmologist’s side requires knowledge of the common, but often underdiagnosed, ocular surface alterations as well as of the signs of drug toxicity. Furthermore, ocular surface biomarkers can be useful for the early diagnosis of PD as well as for monitoring the degree of neural degeneration over time. MDPI 2022-12-19 /pmc/articles/PMC9783883/ /pubmed/36556506 http://dx.doi.org/10.3390/life12122141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Buzzi, Matilde Giannaccare, Giuseppe Cennamo, Michela Bernabei, Federico Rothschild, Pierre-Raphael Vagge, Aldo Scorcia, Vincenzo Mencucci, Rita Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review |
title | Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review |
title_full | Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review |
title_fullStr | Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review |
title_full_unstemmed | Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review |
title_short | Ocular Surface Features in Patients with Parkinson Disease on and off Treatment: A Narrative Review |
title_sort | ocular surface features in patients with parkinson disease on and off treatment: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783883/ https://www.ncbi.nlm.nih.gov/pubmed/36556506 http://dx.doi.org/10.3390/life12122141 |
work_keys_str_mv | AT buzzimatilde ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview AT giannaccaregiuseppe ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview AT cennamomichela ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview AT bernabeifederico ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview AT rothschildpierreraphael ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview AT vaggealdo ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview AT scorciavincenzo ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview AT mencuccirita ocularsurfacefeaturesinpatientswithparkinsondiseaseonandofftreatmentanarrativereview |