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Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches

Ocean acidification (OA) is a dramatic perturbation of seawater environments due to increasing anthropogenic emissions of CO(2). Several studies indicated that OA frequently induces marine biota stress and a reduction of biodiversity. Here, we adopted the macroalga Ulva prolifera as a model and appl...

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Autores principales: Sanchez-Arcos, Carlos, Paris, Debora, Mazzella, Valerio, Mutalipassi, Mirko, Costantini, Maria, Buia, Maria Cristina, von Elert, Eric, Cutignano, Adele, Zupo, Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783899/
https://www.ncbi.nlm.nih.gov/pubmed/36547890
http://dx.doi.org/10.3390/md20120743
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author Sanchez-Arcos, Carlos
Paris, Debora
Mazzella, Valerio
Mutalipassi, Mirko
Costantini, Maria
Buia, Maria Cristina
von Elert, Eric
Cutignano, Adele
Zupo, Valerio
author_facet Sanchez-Arcos, Carlos
Paris, Debora
Mazzella, Valerio
Mutalipassi, Mirko
Costantini, Maria
Buia, Maria Cristina
von Elert, Eric
Cutignano, Adele
Zupo, Valerio
author_sort Sanchez-Arcos, Carlos
collection PubMed
description Ocean acidification (OA) is a dramatic perturbation of seawater environments due to increasing anthropogenic emissions of CO(2). Several studies indicated that OA frequently induces marine biota stress and a reduction of biodiversity. Here, we adopted the macroalga Ulva prolifera as a model and applied a complementary multi-omics approach to investigate the metabolic profiles under normal and acidified conditions. Our results show that U. prolifera grows at higher rates in acidified environments. Consistently, we observed lower sucrose and phosphocreatine concentrations in response to a higher demand of energy for growth and a higher availability of essential amino acids, likely related to increased protein biosynthesis. In addition, pathways leading to signaling and deterrent compounds appeared perturbed. Finally, a remarkable shift was observed here for the first time in the fatty acid composition of triglycerides, with a decrease in the relative abundance of PUFAs towards an appreciable increase of palmitic acid, thus suggesting a remodeling in lipid biosynthesis. Overall, our studies revealed modulation of several biosynthetic pathways under OA conditions in which, besides the possible effects on the marine ecosystem, the metabolic changes of the alga should be taken into account considering its potential nutraceutical applications.
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spelling pubmed-97838992022-12-24 Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches Sanchez-Arcos, Carlos Paris, Debora Mazzella, Valerio Mutalipassi, Mirko Costantini, Maria Buia, Maria Cristina von Elert, Eric Cutignano, Adele Zupo, Valerio Mar Drugs Article Ocean acidification (OA) is a dramatic perturbation of seawater environments due to increasing anthropogenic emissions of CO(2). Several studies indicated that OA frequently induces marine biota stress and a reduction of biodiversity. Here, we adopted the macroalga Ulva prolifera as a model and applied a complementary multi-omics approach to investigate the metabolic profiles under normal and acidified conditions. Our results show that U. prolifera grows at higher rates in acidified environments. Consistently, we observed lower sucrose and phosphocreatine concentrations in response to a higher demand of energy for growth and a higher availability of essential amino acids, likely related to increased protein biosynthesis. In addition, pathways leading to signaling and deterrent compounds appeared perturbed. Finally, a remarkable shift was observed here for the first time in the fatty acid composition of triglycerides, with a decrease in the relative abundance of PUFAs towards an appreciable increase of palmitic acid, thus suggesting a remodeling in lipid biosynthesis. Overall, our studies revealed modulation of several biosynthetic pathways under OA conditions in which, besides the possible effects on the marine ecosystem, the metabolic changes of the alga should be taken into account considering its potential nutraceutical applications. MDPI 2022-11-26 /pmc/articles/PMC9783899/ /pubmed/36547890 http://dx.doi.org/10.3390/md20120743 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sanchez-Arcos, Carlos
Paris, Debora
Mazzella, Valerio
Mutalipassi, Mirko
Costantini, Maria
Buia, Maria Cristina
von Elert, Eric
Cutignano, Adele
Zupo, Valerio
Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches
title Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches
title_full Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches
title_fullStr Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches
title_full_unstemmed Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches
title_short Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches
title_sort responses of the macroalga ulva prolifera müller to ocean acidification revealed by complementary nmr- and ms-based omics approaches
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783899/
https://www.ncbi.nlm.nih.gov/pubmed/36547890
http://dx.doi.org/10.3390/md20120743
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