Nucleolar Stress Response via Ribosomal Protein L11 Regulates Topoisomerase Inhibitor Sensitivity of P53-Intact Cancers

Nucleolar stress response is caused by perturbations in ribosome biogenesis, induced by the inhibition of ribosomal RNA processing and synthesis, as well as ribosome assembly. This response induces p53 stabilization and activation via ribosomal protein L11 (RPL11), suppressing tumor progression. How...

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Detalles Bibliográficos
Autores principales: Ishihara, Yuka, Nakamura, Kiyoshiro, Nakagawa, Shunsuke, Okamoto, Yasuhiro, Yamamoto, Masatatsu, Furukawa, Tatsuhiko, Kawahara, Kohichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784028/
https://www.ncbi.nlm.nih.gov/pubmed/36555627
http://dx.doi.org/10.3390/ijms232415986

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