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Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection
Analysis of cancer biomarkers has enormous promise for advancing our molecular understanding of illness and facilitating more precise and timely diagnosis and follow-up care. MicroRNA, exosomes, ctDNA, CTCs, and proteins are only some of the circulating biomarkers that can be detected by liquid biop...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784037/ https://www.ncbi.nlm.nih.gov/pubmed/36568055 http://dx.doi.org/10.4103/japtr.japtr_106_22 |
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author | Chaudhry, Gul-e-Saba Akim, Abdah Md Safdar, Naila Yasmin, Azra begum, Shaheen Sung, Yeong Yik Muhammad, Tengku Sifzizul Tengku |
author_facet | Chaudhry, Gul-e-Saba Akim, Abdah Md Safdar, Naila Yasmin, Azra begum, Shaheen Sung, Yeong Yik Muhammad, Tengku Sifzizul Tengku |
author_sort | Chaudhry, Gul-e-Saba |
collection | PubMed |
description | Analysis of cancer biomarkers has enormous promise for advancing our molecular understanding of illness and facilitating more precise and timely diagnosis and follow-up care. MicroRNA, exosomes, ctDNA, CTCs, and proteins are only some of the circulating biomarkers that can be detected by liquid biopsy instead of the more intrusive and time-consuming process of doing a tissue biopsy. As the cancer diagnosis bio-markers reveal ultra-low levels in the early stages of the disease, highly sensitive approaches are urgently required. Researchers have taken an interest in a optical biosensor for detecting cancer biomarkers as a potential tool for early disease diagnosis. These techniques have the potential to aid in the development of effective treatments, ultimately leading to a higher rate of patient survival. This review briefly discuss the i) understanding of cancer and biomarkers for early diagonosis purpose ii) Molecular methods and ii) biosensor-based diagnostics. The reseach primary focus on advancement in biosensor design using various concepts ie., Electrochemical, Chemiluminescence and Colorimetric, Surface plasmons (SP), Surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR), Fluorescence, Fiber-based sensors, Terahertz based biosensors, and Surface enhanced Raman spectroscopy (SERS). As a result of the local electric field amplification around plasmonic (usually gold and silver) nanostructures, surface-enhanced Raman spectroscopy (SERS) has emerged as a rapid, selective, and sensitive alternative to conventional laboratory analytical methods, making significant strides in a number of biosensing applications but still under developing stage to be used as diagnostic tool in clinical research. |
format | Online Article Text |
id | pubmed-9784037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-97840372022-12-24 Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection Chaudhry, Gul-e-Saba Akim, Abdah Md Safdar, Naila Yasmin, Azra begum, Shaheen Sung, Yeong Yik Muhammad, Tengku Sifzizul Tengku J Adv Pharm Technol Res Review Article Analysis of cancer biomarkers has enormous promise for advancing our molecular understanding of illness and facilitating more precise and timely diagnosis and follow-up care. MicroRNA, exosomes, ctDNA, CTCs, and proteins are only some of the circulating biomarkers that can be detected by liquid biopsy instead of the more intrusive and time-consuming process of doing a tissue biopsy. As the cancer diagnosis bio-markers reveal ultra-low levels in the early stages of the disease, highly sensitive approaches are urgently required. Researchers have taken an interest in a optical biosensor for detecting cancer biomarkers as a potential tool for early disease diagnosis. These techniques have the potential to aid in the development of effective treatments, ultimately leading to a higher rate of patient survival. This review briefly discuss the i) understanding of cancer and biomarkers for early diagonosis purpose ii) Molecular methods and ii) biosensor-based diagnostics. The reseach primary focus on advancement in biosensor design using various concepts ie., Electrochemical, Chemiluminescence and Colorimetric, Surface plasmons (SP), Surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR), Fluorescence, Fiber-based sensors, Terahertz based biosensors, and Surface enhanced Raman spectroscopy (SERS). As a result of the local electric field amplification around plasmonic (usually gold and silver) nanostructures, surface-enhanced Raman spectroscopy (SERS) has emerged as a rapid, selective, and sensitive alternative to conventional laboratory analytical methods, making significant strides in a number of biosensing applications but still under developing stage to be used as diagnostic tool in clinical research. Wolters Kluwer - Medknow 2022 2022-10-10 /pmc/articles/PMC9784037/ /pubmed/36568055 http://dx.doi.org/10.4103/japtr.japtr_106_22 Text en Copyright: © 2022 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Chaudhry, Gul-e-Saba Akim, Abdah Md Safdar, Naila Yasmin, Azra begum, Shaheen Sung, Yeong Yik Muhammad, Tengku Sifzizul Tengku Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection |
title | Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection |
title_full | Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection |
title_fullStr | Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection |
title_full_unstemmed | Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection |
title_short | Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection |
title_sort | cancer and disease diagnosis - biosensor as potential diagnostic tool for biomarker detection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784037/ https://www.ncbi.nlm.nih.gov/pubmed/36568055 http://dx.doi.org/10.4103/japtr.japtr_106_22 |
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