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Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection

Analysis of cancer biomarkers has enormous promise for advancing our molecular understanding of illness and facilitating more precise and timely diagnosis and follow-up care. MicroRNA, exosomes, ctDNA, CTCs, and proteins are only some of the circulating biomarkers that can be detected by liquid biop...

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Autores principales: Chaudhry, Gul-e-Saba, Akim, Abdah Md, Safdar, Naila, Yasmin, Azra, begum, Shaheen, Sung, Yeong Yik, Muhammad, Tengku Sifzizul Tengku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784037/
https://www.ncbi.nlm.nih.gov/pubmed/36568055
http://dx.doi.org/10.4103/japtr.japtr_106_22
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author Chaudhry, Gul-e-Saba
Akim, Abdah Md
Safdar, Naila
Yasmin, Azra
begum, Shaheen
Sung, Yeong Yik
Muhammad, Tengku Sifzizul Tengku
author_facet Chaudhry, Gul-e-Saba
Akim, Abdah Md
Safdar, Naila
Yasmin, Azra
begum, Shaheen
Sung, Yeong Yik
Muhammad, Tengku Sifzizul Tengku
author_sort Chaudhry, Gul-e-Saba
collection PubMed
description Analysis of cancer biomarkers has enormous promise for advancing our molecular understanding of illness and facilitating more precise and timely diagnosis and follow-up care. MicroRNA, exosomes, ctDNA, CTCs, and proteins are only some of the circulating biomarkers that can be detected by liquid biopsy instead of the more intrusive and time-consuming process of doing a tissue biopsy. As the cancer diagnosis bio-markers reveal ultra-low levels in the early stages of the disease, highly sensitive approaches are urgently required. Researchers have taken an interest in a optical biosensor for detecting cancer biomarkers as a potential tool for early disease diagnosis. These techniques have the potential to aid in the development of effective treatments, ultimately leading to a higher rate of patient survival. This review briefly discuss the i) understanding of cancer and biomarkers for early diagonosis purpose ii) Molecular methods and ii) biosensor-based diagnostics. The reseach primary focus on advancement in biosensor design using various concepts ie., Electrochemical, Chemiluminescence and Colorimetric, Surface plasmons (SP), Surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR), Fluorescence, Fiber-based sensors, Terahertz based biosensors, and Surface enhanced Raman spectroscopy (SERS). As a result of the local electric field amplification around plasmonic (usually gold and silver) nanostructures, surface-enhanced Raman spectroscopy (SERS) has emerged as a rapid, selective, and sensitive alternative to conventional laboratory analytical methods, making significant strides in a number of biosensing applications but still under developing stage to be used as diagnostic tool in clinical research.
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spelling pubmed-97840372022-12-24 Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection Chaudhry, Gul-e-Saba Akim, Abdah Md Safdar, Naila Yasmin, Azra begum, Shaheen Sung, Yeong Yik Muhammad, Tengku Sifzizul Tengku J Adv Pharm Technol Res Review Article Analysis of cancer biomarkers has enormous promise for advancing our molecular understanding of illness and facilitating more precise and timely diagnosis and follow-up care. MicroRNA, exosomes, ctDNA, CTCs, and proteins are only some of the circulating biomarkers that can be detected by liquid biopsy instead of the more intrusive and time-consuming process of doing a tissue biopsy. As the cancer diagnosis bio-markers reveal ultra-low levels in the early stages of the disease, highly sensitive approaches are urgently required. Researchers have taken an interest in a optical biosensor for detecting cancer biomarkers as a potential tool for early disease diagnosis. These techniques have the potential to aid in the development of effective treatments, ultimately leading to a higher rate of patient survival. This review briefly discuss the i) understanding of cancer and biomarkers for early diagonosis purpose ii) Molecular methods and ii) biosensor-based diagnostics. The reseach primary focus on advancement in biosensor design using various concepts ie., Electrochemical, Chemiluminescence and Colorimetric, Surface plasmons (SP), Surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR), Fluorescence, Fiber-based sensors, Terahertz based biosensors, and Surface enhanced Raman spectroscopy (SERS). As a result of the local electric field amplification around plasmonic (usually gold and silver) nanostructures, surface-enhanced Raman spectroscopy (SERS) has emerged as a rapid, selective, and sensitive alternative to conventional laboratory analytical methods, making significant strides in a number of biosensing applications but still under developing stage to be used as diagnostic tool in clinical research. Wolters Kluwer - Medknow 2022 2022-10-10 /pmc/articles/PMC9784037/ /pubmed/36568055 http://dx.doi.org/10.4103/japtr.japtr_106_22 Text en Copyright: © 2022 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Chaudhry, Gul-e-Saba
Akim, Abdah Md
Safdar, Naila
Yasmin, Azra
begum, Shaheen
Sung, Yeong Yik
Muhammad, Tengku Sifzizul Tengku
Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection
title Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection
title_full Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection
title_fullStr Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection
title_full_unstemmed Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection
title_short Cancer and Disease Diagnosis - Biosensor as Potential Diagnostic Tool for Biomarker Detection
title_sort cancer and disease diagnosis - biosensor as potential diagnostic tool for biomarker detection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784037/
https://www.ncbi.nlm.nih.gov/pubmed/36568055
http://dx.doi.org/10.4103/japtr.japtr_106_22
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