The YTHDF1–TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray

Long-term use of opioids such as morphine has negative side effects, such as morphine analgesic tolerance and morphine-induced hyperalgesia (MIH). These side effects limit the clinical use and analgesic efficacy of morphine. Elucidation of the mechanisms and identification of feasible and effective...

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Detalles Bibliográficos
Autores principales: Ouyang, Handong, Zhang, Jianxing, Chi, Dongmei, Zhang, Kun, Huang, Yongtian, Huang, Jingxiu, Huang, Wan, Bai, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784087/
https://www.ncbi.nlm.nih.gov/pubmed/36550542
http://dx.doi.org/10.1186/s12974-022-02672-y

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