The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases

MicroRNAs (miRNAs) are a class of short, endogenous, non-coding, single-stranded RNAs that can negatively regulate the post-transcriptional expression of target genes. Among them, miR-15a/16 is involved in the regulation of the occurrence and development of fibrosis in the liver, lungs, heart, kidne...

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Detalles Bibliográficos
Autores principales: Wen, Dada, Zhang, Huamin, Zhou, Yutong, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784154/
https://www.ncbi.nlm.nih.gov/pubmed/36555676
http://dx.doi.org/10.3390/ijms232416041
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author Wen, Dada
Zhang, Huamin
Zhou, Yutong
Wang, Jie
author_facet Wen, Dada
Zhang, Huamin
Zhou, Yutong
Wang, Jie
author_sort Wen, Dada
collection PubMed
description MicroRNAs (miRNAs) are a class of short, endogenous, non-coding, single-stranded RNAs that can negatively regulate the post-transcriptional expression of target genes. Among them, miR-15a/16 is involved in the regulation of the occurrence and development of fibrosis in the liver, lungs, heart, kidneys, and other organs, as well as systemic fibrotic diseases, affecting important cellular functions, such as cell transformation, the synthesis and degradation of extracellular matrix, and the release of fibrotic mediators. Therefore, this article reviews the biological characteristics of miR-15a/16 and the molecular mechanisms and functions of their dysregulation in fibrotic diseases.
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spelling pubmed-97841542022-12-24 The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases Wen, Dada Zhang, Huamin Zhou, Yutong Wang, Jie Int J Mol Sci Review MicroRNAs (miRNAs) are a class of short, endogenous, non-coding, single-stranded RNAs that can negatively regulate the post-transcriptional expression of target genes. Among them, miR-15a/16 is involved in the regulation of the occurrence and development of fibrosis in the liver, lungs, heart, kidneys, and other organs, as well as systemic fibrotic diseases, affecting important cellular functions, such as cell transformation, the synthesis and degradation of extracellular matrix, and the release of fibrotic mediators. Therefore, this article reviews the biological characteristics of miR-15a/16 and the molecular mechanisms and functions of their dysregulation in fibrotic diseases. MDPI 2022-12-16 /pmc/articles/PMC9784154/ /pubmed/36555676 http://dx.doi.org/10.3390/ijms232416041 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wen, Dada
Zhang, Huamin
Zhou, Yutong
Wang, Jie
The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases
title The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases
title_full The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases
title_fullStr The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases
title_full_unstemmed The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases
title_short The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases
title_sort molecular mechanisms and function of mir-15a/16 dysregulation in fibrotic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784154/
https://www.ncbi.nlm.nih.gov/pubmed/36555676
http://dx.doi.org/10.3390/ijms232416041
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