Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons

ALS-linked mutations induce aberrant conformations within the SOD1 protein that are thought to underlie the pathogenic mechanism of SOD1-mediated ALS. Although clinical trials are underway for gene silencing of SOD1, these approaches reduce both wild-type and mutated forms of SOD1. Here, we sought t...

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Detalles Bibliográficos
Autores principales: Kumar, Meenakshi Sundaram, Fowler-Magaw, Megan E., Kulick, Daniel, Boopathy, Sivakumar, Gadd, Del Hayden, Rotunno, Melissa, Douthwright, Catherine, Golebiowski, Diane, Yusuf, Issa, Xu, Zuoshang, Brown, Robert H., Sena-Esteves, Miguel, O’Neil, Alison L., Bosco, Daryl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784173/
https://www.ncbi.nlm.nih.gov/pubmed/36555655
http://dx.doi.org/10.3390/ijms232416013

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