Cargando…

Therapeutic Effect of a Latent Form of Cortistatin in Experimental Inflammatory and Fibrotic Disorders

Cortistatin is a cyclic neuropeptide that recently emerged as an attractive therapeutic factor for treating inflammatory, autoimmune, fibrotic, and pain disorders. Despite of its efficiency and apparent safety in experimental preclinical models, its short half-life in body fluids and its potential p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Campos-Salinas, Jenny, Barriga, Margarita, Delgado, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784182/ https://www.ncbi.nlm.nih.gov/pubmed/36559278 http://dx.doi.org/10.3390/pharmaceutics14122785

Ejemplares similares

Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia
por: Gonzalez-Rey, Elena, et al.
Publicado: (2006)

The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury
por: Falo, Clara P., et al.
Publicado: (2021)

Synthesis of (+)-Cortistatin A
por: Shenvi, Ryan A., et al.
Publicado: (2008)

Anti-inflammatory effect of cortistatin in rat endotoxin-induced uveitis model
por: Balbaba, Mehmet, et al.
Publicado: (2020)

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
por: Rol, Álvaro, et al.
Publicado: (2021)

Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin
por: Sáez-Martínez, Prudencio, et al.
Publicado: (2022)

Cortistatin reduces atherosclerosis in hyperlipidemic ApoE-deficient mice and the formation of foam cells
por: Delgado-Maroto, Virginia, et al.
Publicado: (2017)

Synthesis of Cortistatins A, J, K, and L
por: Flyer, Alec N., et al.
Publicado: (2010)

Cortistatin binds to TNF-α receptors and protects against osteoarthritis
por: Zhao, Yunpeng, et al.
Publicado: (2019)

Cardioprotection of cortistatin against isoproterenol-induced myocardial injury in rats
por: Chen, Wenjia, et al.
Publicado: (2020)

TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons
por: Maynard, Kristen R., et al.
Publicado: (2020)

Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion
por: Rafacho, Alex, et al.
Publicado: (2015)

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency
por: Mousseau, Guillaume, et al.
Publicado: (2015)

Unexpected Mutations in HIV-1 That Confer Resistance to the Tat Inhibitor Didehydro-Cortistatin A
por: Rice, Andrew P.
Publicado: (2019)

Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation
por: Carrasco, Esther, et al.
Publicado: (2008)

Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior
por: Martinowich, Keri, et al.
Publicado: (2011)

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice
por: Luque, Raúl M., et al.
Publicado: (2016)

Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat
por: Mediouni, Sonia, et al.
Publicado: (2019)

Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription
por: Mousseau, Guillaume, et al.
Publicado: (2019)

Evaluation of a Novel DNA Vaccine Double Encoding Somatostatin and Cortistatin for Promoting the Growth of Mice
por: Luo, Xuan, et al.
Publicado: (2022)

Obesity Alters Gene Expression for GH/IGF-I Axis in Mouse Mammary Fat Pads: Differential Role of Cortistatin and Somatostatin
por: Villa-Osaba, Alicia, et al.
Publicado: (2015)

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease
por: Boaru, Sorina Georgiana, et al.
Publicado: (2012)

Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions
por: Chanclón, Belén, et al.
Publicado: (2013)

Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat
por: Li, Chuan, et al.
Publicado: (2019)

Serum Cortistatin Level in Type 2 Diabetes Mellitus and Its Relationship with Nonalcoholic Fatty Liver Disease
por: Sun, Tiantian, et al.
Publicado: (2023)

Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode
por: Luque, Raúl M., et al.
Publicado: (2016)

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders
por: Di Gregorio, Jacopo, et al.
Publicado: (2020)

Chemokine-Based Therapeutics for the Treatment of Inflammatory and Fibrotic Convergent Pathways in COVID-19
por: Julian, Dana R., et al.
Publicado: (2021)

Cortistatin-14 Exerts Neuroprotective Effect Against Microglial Activation, Blood-brain Barrier Disruption, and Cognitive Impairment in Sepsis-associated Encephalopathy
por: Wen, Qiang, et al.
Publicado: (2022)

Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
por: Zhao, Yunpeng, et al.
Publicado: (2020)

Proteomics approaches to fibrotic disorders
por: Gucek, Marjan
Publicado: (2012)

Inflammatory and Fibrotic Mediators in Renal Diseases
por: Rayego-Mateos, Sandra, et al.
Publicado: (2019)

Microvascular Targets for Anti-Fibrotic Therapeutics
por: Pu, Kai-Ming T., et al.
Publicado: (2013)

Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis
por: Costalonga, Elerson C., et al.
Publicado: (2017)

Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
por: Castillo-González, Julia, et al.
Publicado: (2023)

Therapeutic Approach to Adult Fibrotic Lung Diseases
por: Adegunsoye, Ayodeji, et al.
Publicado: (2016)

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics
por: Dolivo, David, et al.
Publicado: (2021)

Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases
por: Chen, Yingqing, et al.
Publicado: (2021)

Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice
por: Han, Hongwei, et al.
Publicado: (2021)

Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases
por: Ryu, Jae-Sung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4sg4nmpistopkem752pq3k0e01