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Dietary and lifestyle associations with microbiome diversity
BACKGROUND: Microbial dysbiosis has been closely linked with colorectal cancer development. However, data is limited regarding the relationship of the mucosal microbiome, adenomatous polyps and dietary habits. Understanding these associations may elucidate pathways for risk stratification according...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784278/ https://www.ncbi.nlm.nih.gov/pubmed/36564812 http://dx.doi.org/10.1186/s13099-022-00525-w |
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author | Watson, Katherine M. Siemens, Kyla N. Anand, Sudarshan Gardner, Ivy H. Sharpton, Thomas J. Dewey, Elizabeth N. Martindale, Robert Gaulke, Christopher A. Tsikitis, Vassiliki Liana |
author_facet | Watson, Katherine M. Siemens, Kyla N. Anand, Sudarshan Gardner, Ivy H. Sharpton, Thomas J. Dewey, Elizabeth N. Martindale, Robert Gaulke, Christopher A. Tsikitis, Vassiliki Liana |
author_sort | Watson, Katherine M. |
collection | PubMed |
description | BACKGROUND: Microbial dysbiosis has been closely linked with colorectal cancer development. However, data is limited regarding the relationship of the mucosal microbiome, adenomatous polyps and dietary habits. Understanding these associations may elucidate pathways for risk stratification according to diet. RESULTS: Patients undergoing screening colonoscopy were included in our prospective, single center study and divided into adenoma or no adenoma cohorts. Oral, fecal, and mucosal samples were obtained. Microbial DNA was extracted, and amplicon libraries generated using primers for the 16S rRNA gene V4 region. Patient and dietary information was collected. Of 104 participants, 44% presented with polyps, which were predominantly tubular adenomas (87%). Adenoma formation and multiple patient dietary and lifestyle characteristics were associated with mucosal microbiome diversity. Lifestyle factors included age, body mass index, adenoma number, and dietary consumption of red meats, processed meats, vegetables, fruit, grain, fermented foods and alcohol. CONCLUSION: In this study we showed associations between dietary habits, adenoma formation and the mucosal microbiome. These early findings suggest that ongoing research into diet modification may help reduce adenoma formation and subsequently the development of CRC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13099-022-00525-w. |
format | Online Article Text |
id | pubmed-9784278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-97842782022-12-24 Dietary and lifestyle associations with microbiome diversity Watson, Katherine M. Siemens, Kyla N. Anand, Sudarshan Gardner, Ivy H. Sharpton, Thomas J. Dewey, Elizabeth N. Martindale, Robert Gaulke, Christopher A. Tsikitis, Vassiliki Liana Gut Pathog Brief Report BACKGROUND: Microbial dysbiosis has been closely linked with colorectal cancer development. However, data is limited regarding the relationship of the mucosal microbiome, adenomatous polyps and dietary habits. Understanding these associations may elucidate pathways for risk stratification according to diet. RESULTS: Patients undergoing screening colonoscopy were included in our prospective, single center study and divided into adenoma or no adenoma cohorts. Oral, fecal, and mucosal samples were obtained. Microbial DNA was extracted, and amplicon libraries generated using primers for the 16S rRNA gene V4 region. Patient and dietary information was collected. Of 104 participants, 44% presented with polyps, which were predominantly tubular adenomas (87%). Adenoma formation and multiple patient dietary and lifestyle characteristics were associated with mucosal microbiome diversity. Lifestyle factors included age, body mass index, adenoma number, and dietary consumption of red meats, processed meats, vegetables, fruit, grain, fermented foods and alcohol. CONCLUSION: In this study we showed associations between dietary habits, adenoma formation and the mucosal microbiome. These early findings suggest that ongoing research into diet modification may help reduce adenoma formation and subsequently the development of CRC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13099-022-00525-w. BioMed Central 2022-12-23 /pmc/articles/PMC9784278/ /pubmed/36564812 http://dx.doi.org/10.1186/s13099-022-00525-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Brief Report Watson, Katherine M. Siemens, Kyla N. Anand, Sudarshan Gardner, Ivy H. Sharpton, Thomas J. Dewey, Elizabeth N. Martindale, Robert Gaulke, Christopher A. Tsikitis, Vassiliki Liana Dietary and lifestyle associations with microbiome diversity |
title | Dietary and lifestyle associations with microbiome diversity |
title_full | Dietary and lifestyle associations with microbiome diversity |
title_fullStr | Dietary and lifestyle associations with microbiome diversity |
title_full_unstemmed | Dietary and lifestyle associations with microbiome diversity |
title_short | Dietary and lifestyle associations with microbiome diversity |
title_sort | dietary and lifestyle associations with microbiome diversity |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784278/ https://www.ncbi.nlm.nih.gov/pubmed/36564812 http://dx.doi.org/10.1186/s13099-022-00525-w |
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