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Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants

Recently, the biosynthesis of gold nanoparticles (AuNPs) has been widely studied and described. In the age of bacterial drug resistance, an intensive search for new agents with antibacterial properties or a new form of antibiotics with effective action is necessary. As a result, the antibacterial ac...

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Autores principales: Timoszyk, Anna, Grochowalska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784296/
https://www.ncbi.nlm.nih.gov/pubmed/36559093
http://dx.doi.org/10.3390/pharmaceutics14122599
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author Timoszyk, Anna
Grochowalska, Renata
author_facet Timoszyk, Anna
Grochowalska, Renata
author_sort Timoszyk, Anna
collection PubMed
description Recently, the biosynthesis of gold nanoparticles (AuNPs) has been widely studied and described. In the age of bacterial drug resistance, an intensive search for new agents with antibacterial properties or a new form of antibiotics with effective action is necessary. As a result, the antibacterial activity of AuNPs functionalized with natural compounds is being investigated more frequently. AuNPs biosynthesized with plant extract or functionalized with bioactive compounds isolated from plants could be particularly useful for pharmaceutical applications. The biosynthesized AuNPs are stabilized by an envelope, which may consist of flavonoids, phenolic acids, lipids and proteins as well as carbohydrates and vitamins. The composition of the natural coating affects the size, shape and stability of the AuNPs and is also responsible for interactions with the bacterial cell wall. Recently, several mechanisms of AuNP interactions with bacterial cells have been identified. Nevertheless, they are not yet well understood, due to the large diversity of plants and biosynthesized AuNPs. Understanding the antibacterial mechanisms allows for the creation of pharmaceutical formulations in the most useful form. Utilizing AuNPs functionalized with plant compounds as antibacterial agents is still a new concept. However, the unique physicochemical and biological properties of AuNPs emphasises their potential for a broad range of applications in the future.
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spelling pubmed-97842962022-12-24 Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants Timoszyk, Anna Grochowalska, Renata Pharmaceutics Review Recently, the biosynthesis of gold nanoparticles (AuNPs) has been widely studied and described. In the age of bacterial drug resistance, an intensive search for new agents with antibacterial properties or a new form of antibiotics with effective action is necessary. As a result, the antibacterial activity of AuNPs functionalized with natural compounds is being investigated more frequently. AuNPs biosynthesized with plant extract or functionalized with bioactive compounds isolated from plants could be particularly useful for pharmaceutical applications. The biosynthesized AuNPs are stabilized by an envelope, which may consist of flavonoids, phenolic acids, lipids and proteins as well as carbohydrates and vitamins. The composition of the natural coating affects the size, shape and stability of the AuNPs and is also responsible for interactions with the bacterial cell wall. Recently, several mechanisms of AuNP interactions with bacterial cells have been identified. Nevertheless, they are not yet well understood, due to the large diversity of plants and biosynthesized AuNPs. Understanding the antibacterial mechanisms allows for the creation of pharmaceutical formulations in the most useful form. Utilizing AuNPs functionalized with plant compounds as antibacterial agents is still a new concept. However, the unique physicochemical and biological properties of AuNPs emphasises their potential for a broad range of applications in the future. MDPI 2022-11-25 /pmc/articles/PMC9784296/ /pubmed/36559093 http://dx.doi.org/10.3390/pharmaceutics14122599 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Timoszyk, Anna
Grochowalska, Renata
Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants
title Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants
title_full Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants
title_fullStr Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants
title_full_unstemmed Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants
title_short Mechanism and Antibacterial Activity of Gold Nanoparticles (AuNPs) Functionalized with Natural Compounds from Plants
title_sort mechanism and antibacterial activity of gold nanoparticles (aunps) functionalized with natural compounds from plants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784296/
https://www.ncbi.nlm.nih.gov/pubmed/36559093
http://dx.doi.org/10.3390/pharmaceutics14122599
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