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Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study
Aflatoxin can cross the blood–brain barrier, damage brain tissues, and have the potential to harm the development of the human brain. Although dietary aflatoxin exposure is common in children, there is a paucity of data on aflatoxin exposure and child developmental outcomes. The child’s cognitive, m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784379/ https://www.ncbi.nlm.nih.gov/pubmed/36548752 http://dx.doi.org/10.3390/toxins14120855 |
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author | Mahfuz, Mustafa Hossain, Md. Shabab Alam, Md. Ashraful Gazi, Md. Amran Fahim, Shah Mohammad Nahar, Baitun Ahmed, Tahmeed |
author_facet | Mahfuz, Mustafa Hossain, Md. Shabab Alam, Md. Ashraful Gazi, Md. Amran Fahim, Shah Mohammad Nahar, Baitun Ahmed, Tahmeed |
author_sort | Mahfuz, Mustafa |
collection | PubMed |
description | Aflatoxin can cross the blood–brain barrier, damage brain tissues, and have the potential to harm the development of the human brain. Although dietary aflatoxin exposure is common in children, there is a paucity of data on aflatoxin exposure and child developmental outcomes. The child’s cognitive, motor, and language functions were assessed using the Bayley Scales of Infant and Toddler Development-III or BSID-III at the same time points. Association between exposure to aflatoxin and subtests of BSID-III were examined using mixed-effect linear regression. Aflatoxin assays were performed on 194, 167, and 163 children at 15, 24, and 36 months of age, and chronic aflatoxin exposure was detected in 20.6%, 16.8%, and 60.7% of children, respectively. Multi-variable analyses showed that aflatoxin exposure was independently related to the children’s cognitive score (β: −0.69; 95% CI: −1.36, −0.02), receptive language score (β: −0.90; 95% CI: −1.62, −0.17), and expressive language score (β: −1.01; 95% CI: −1.96, −0.05). We did not observe any association between exposure to aflatoxin and the motor function of children. Chronic exposure to aflatoxin exposure was linked to reduced cognitive, expressive, and receptive language scores of the study children. Further research is needed in a different setting to confirm this novel finding. |
format | Online Article Text |
id | pubmed-9784379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97843792022-12-24 Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study Mahfuz, Mustafa Hossain, Md. Shabab Alam, Md. Ashraful Gazi, Md. Amran Fahim, Shah Mohammad Nahar, Baitun Ahmed, Tahmeed Toxins (Basel) Article Aflatoxin can cross the blood–brain barrier, damage brain tissues, and have the potential to harm the development of the human brain. Although dietary aflatoxin exposure is common in children, there is a paucity of data on aflatoxin exposure and child developmental outcomes. The child’s cognitive, motor, and language functions were assessed using the Bayley Scales of Infant and Toddler Development-III or BSID-III at the same time points. Association between exposure to aflatoxin and subtests of BSID-III were examined using mixed-effect linear regression. Aflatoxin assays were performed on 194, 167, and 163 children at 15, 24, and 36 months of age, and chronic aflatoxin exposure was detected in 20.6%, 16.8%, and 60.7% of children, respectively. Multi-variable analyses showed that aflatoxin exposure was independently related to the children’s cognitive score (β: −0.69; 95% CI: −1.36, −0.02), receptive language score (β: −0.90; 95% CI: −1.62, −0.17), and expressive language score (β: −1.01; 95% CI: −1.96, −0.05). We did not observe any association between exposure to aflatoxin and the motor function of children. Chronic exposure to aflatoxin exposure was linked to reduced cognitive, expressive, and receptive language scores of the study children. Further research is needed in a different setting to confirm this novel finding. MDPI 2022-12-03 /pmc/articles/PMC9784379/ /pubmed/36548752 http://dx.doi.org/10.3390/toxins14120855 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mahfuz, Mustafa Hossain, Md. Shabab Alam, Md. Ashraful Gazi, Md. Amran Fahim, Shah Mohammad Nahar, Baitun Ahmed, Tahmeed Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study |
title | Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study |
title_full | Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study |
title_fullStr | Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study |
title_full_unstemmed | Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study |
title_short | Chronic Aflatoxin Exposure and Cognitive and Language Development in Young Children of Bangladesh: A Longitudinal Study |
title_sort | chronic aflatoxin exposure and cognitive and language development in young children of bangladesh: a longitudinal study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784379/ https://www.ncbi.nlm.nih.gov/pubmed/36548752 http://dx.doi.org/10.3390/toxins14120855 |
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