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Characterization of Sigma-2 Receptor—Specific Binding Sites Using [(3)H]DTG and [(125)I]RHM-4

The sigma-2 receptor/transmembrane protein 97 (σ2R/TMRM97) is a promising biomarker of tumor proliferation and a target for cancer therapy. [(3)H]DTG has been used to evaluate σ2R/TMEM97 binding affinity in compound development studies. However, [(3)H]DTG has equal and moderate binding affinities to...

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Detalles Bibliográficos
Autores principales:	Weng, Chi-Chang, Riad, Aladdin, Lieberman, Brian P., Xu, Kuiying, Peng, Xin, Mikitsh, John L., Mach, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784403/ https://www.ncbi.nlm.nih.gov/pubmed/36559015 http://dx.doi.org/10.3390/ph15121564

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