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A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems
Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784417/ https://www.ncbi.nlm.nih.gov/pubmed/36559799 http://dx.doi.org/10.3390/polym14245432 |
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author | Farasati Far, Bahareh Naimi-Jamal, Mohammad Reza Safaei, Maryam Zarei, Kimia Moradi, Marzieh Yazdani Nezhad, Hamed |
author_facet | Farasati Far, Bahareh Naimi-Jamal, Mohammad Reza Safaei, Maryam Zarei, Kimia Moradi, Marzieh Yazdani Nezhad, Hamed |
author_sort | Farasati Far, Bahareh |
collection | PubMed |
description | Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides. |
format | Online Article Text |
id | pubmed-9784417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97844172022-12-24 A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems Farasati Far, Bahareh Naimi-Jamal, Mohammad Reza Safaei, Maryam Zarei, Kimia Moradi, Marzieh Yazdani Nezhad, Hamed Polymers (Basel) Review Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides. MDPI 2022-12-12 /pmc/articles/PMC9784417/ /pubmed/36559799 http://dx.doi.org/10.3390/polym14245432 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Farasati Far, Bahareh Naimi-Jamal, Mohammad Reza Safaei, Maryam Zarei, Kimia Moradi, Marzieh Yazdani Nezhad, Hamed A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
title | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
title_full | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
title_fullStr | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
title_full_unstemmed | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
title_short | A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems |
title_sort | review on biomedical application of polysaccharide-based hydrogels with a focus on drug delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784417/ https://www.ncbi.nlm.nih.gov/pubmed/36559799 http://dx.doi.org/10.3390/polym14245432 |
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