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Do Mesenchymal Stem Cells Influence Keloid Recurrence?
INTRODUCTION: Mesenchymal stem cells (MSCs) have been postulated by a number of authors to be the precursor cells of fibroblasts and myofibroblasts in keloids. They have been seen as a regenerative pool that ensures a steady supply of cells. The objective of our study was to determine MSCs in keloid...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784453/ https://www.ncbi.nlm.nih.gov/pubmed/36567761 http://dx.doi.org/10.2147/SCCAA.S373551 |
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author | Nang’ole, Wanjala Ferdinand Omu, Anzala Ogeng’o, Julius A Agak, George W |
author_facet | Nang’ole, Wanjala Ferdinand Omu, Anzala Ogeng’o, Julius A Agak, George W |
author_sort | Nang’ole, Wanjala Ferdinand |
collection | PubMed |
description | INTRODUCTION: Mesenchymal stem cells (MSCs) have been postulated by a number of authors to be the precursor cells of fibroblasts and myofibroblasts in keloids. They have been seen as a regenerative pool that ensures a steady supply of cells. The objective of our study was to determine MSCs in keloids and normal skin as a determinant of keloid recurrence. METHODS: This was a longitudinal prospective study in which patients with keloid excisions of their specimens analyzed for MSC. A control group of patients matched for age, sex, and body-mass index (BMI) with no history of keloids admitted for elective surgical procedures had their skin samples taken and also analyzed for MSCs. Data collected were analyzed and compared using Student’s t, x(2), and Fisher’s exact t tests. RESULTS: A total of 61 patients with keloids and a control group of 32 patients were recruited. The male:female ratio was 1:2 and mean age 29.5 and 29.7 years for keloids and controls, respectively. Patients with recurrent keloids had a mean density of 841.4 MSCs/g compared to 578 MSCs/g of tissue for those with no recurrence and 580 MSCs/g for patients with normal skin. Recurrent keloids had a significantly higher percentage of MSCs than those without. CONCLUSION: Keloids compared to normal skin had a higher percentage of MSCs, with recurrent keloids demonstrating an even higher count, a possible indicator that MSCs might correlate with severity of keloid disease and recurrence. |
format | Online Article Text |
id | pubmed-9784453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-97844532022-12-24 Do Mesenchymal Stem Cells Influence Keloid Recurrence? Nang’ole, Wanjala Ferdinand Omu, Anzala Ogeng’o, Julius A Agak, George W Stem Cells Cloning Original Research INTRODUCTION: Mesenchymal stem cells (MSCs) have been postulated by a number of authors to be the precursor cells of fibroblasts and myofibroblasts in keloids. They have been seen as a regenerative pool that ensures a steady supply of cells. The objective of our study was to determine MSCs in keloids and normal skin as a determinant of keloid recurrence. METHODS: This was a longitudinal prospective study in which patients with keloid excisions of their specimens analyzed for MSC. A control group of patients matched for age, sex, and body-mass index (BMI) with no history of keloids admitted for elective surgical procedures had their skin samples taken and also analyzed for MSCs. Data collected were analyzed and compared using Student’s t, x(2), and Fisher’s exact t tests. RESULTS: A total of 61 patients with keloids and a control group of 32 patients were recruited. The male:female ratio was 1:2 and mean age 29.5 and 29.7 years for keloids and controls, respectively. Patients with recurrent keloids had a mean density of 841.4 MSCs/g compared to 578 MSCs/g of tissue for those with no recurrence and 580 MSCs/g for patients with normal skin. Recurrent keloids had a significantly higher percentage of MSCs than those without. CONCLUSION: Keloids compared to normal skin had a higher percentage of MSCs, with recurrent keloids demonstrating an even higher count, a possible indicator that MSCs might correlate with severity of keloid disease and recurrence. Dove 2022-12-19 /pmc/articles/PMC9784453/ /pubmed/36567761 http://dx.doi.org/10.2147/SCCAA.S373551 Text en © 2022 Nang’ole et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Nang’ole, Wanjala Ferdinand Omu, Anzala Ogeng’o, Julius A Agak, George W Do Mesenchymal Stem Cells Influence Keloid Recurrence? |
title | Do Mesenchymal Stem Cells Influence Keloid Recurrence? |
title_full | Do Mesenchymal Stem Cells Influence Keloid Recurrence? |
title_fullStr | Do Mesenchymal Stem Cells Influence Keloid Recurrence? |
title_full_unstemmed | Do Mesenchymal Stem Cells Influence Keloid Recurrence? |
title_short | Do Mesenchymal Stem Cells Influence Keloid Recurrence? |
title_sort | do mesenchymal stem cells influence keloid recurrence? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784453/ https://www.ncbi.nlm.nih.gov/pubmed/36567761 http://dx.doi.org/10.2147/SCCAA.S373551 |
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