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A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia
Objective: To provide an evaluation of incidence and six-month mortality rates of polymicrobial Staphylococcus aureus bacteremia (p-SAB) in the United States (US). Methods: A retrospective population-based study of all incident adults with monomicrobial SAB (m-SAB) and p-SAB in Olmsted County, Minne...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784487/ https://www.ncbi.nlm.nih.gov/pubmed/36558831 http://dx.doi.org/10.3390/pathogens11121499 |
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author | Hindy, Joya-Rita Quintero-Martinez, Juan A. Lahr, Brian D. DeSimone, Daniel C. Baddour, Larry M. |
author_facet | Hindy, Joya-Rita Quintero-Martinez, Juan A. Lahr, Brian D. DeSimone, Daniel C. Baddour, Larry M. |
author_sort | Hindy, Joya-Rita |
collection | PubMed |
description | Objective: To provide an evaluation of incidence and six-month mortality rates of polymicrobial Staphylococcus aureus bacteremia (p-SAB) in the United States (US). Methods: A retrospective population-based study of all incident adults with monomicrobial SAB (m-SAB) and p-SAB in Olmsted County, Minnesota (MN) from 1 January 2006, through 31 December 2020, was conducted. Demographics, clinical characteristics, in-hospital outcomes, and six-month survival were compared between groups. Results: Overall, 31 incident p-SAB cases occurred during the 15-year study period, corresponding to an overall age- and sex-standardized incidence rate of 1.9/100,000 person-years (95% CI, 1.3–2.6). One-third of p-SAB cases were due to MRSA, and almost one-half (15/31) were caused by Gram-positive bacteria. As compared to the 541 cases with incident m-SAB, p-SAB patients were more likely to have a catheter-related infection (p = 0.008) and less likely to be community-acquired cases (p = 0.027). The unadjusted risk of six-month mortality was greater in the p-SAB group (14/31, 45.2%) compared to the m-SAB group (144/541, 26.6%) (HR = 1.94, 95% CI = 1.12–3.36, p = 0.018). After adjusting for relevant covariates, this difference approached significance (HR = 1.93, 95% = CI 0.96–3.87, p = 0.064). Conclusions: To our knowledge, the current investigation represents the only US population-based study evaluating p-SAB patients. We found lower incidence rates for p-SAB than previously reported, with almost one-half of the cases caused by Gram-positive bacteria. Furthermore, these patients had poor survival compared to incident m-SAB cases. |
format | Online Article Text |
id | pubmed-9784487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97844872022-12-24 A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia Hindy, Joya-Rita Quintero-Martinez, Juan A. Lahr, Brian D. DeSimone, Daniel C. Baddour, Larry M. Pathogens Article Objective: To provide an evaluation of incidence and six-month mortality rates of polymicrobial Staphylococcus aureus bacteremia (p-SAB) in the United States (US). Methods: A retrospective population-based study of all incident adults with monomicrobial SAB (m-SAB) and p-SAB in Olmsted County, Minnesota (MN) from 1 January 2006, through 31 December 2020, was conducted. Demographics, clinical characteristics, in-hospital outcomes, and six-month survival were compared between groups. Results: Overall, 31 incident p-SAB cases occurred during the 15-year study period, corresponding to an overall age- and sex-standardized incidence rate of 1.9/100,000 person-years (95% CI, 1.3–2.6). One-third of p-SAB cases were due to MRSA, and almost one-half (15/31) were caused by Gram-positive bacteria. As compared to the 541 cases with incident m-SAB, p-SAB patients were more likely to have a catheter-related infection (p = 0.008) and less likely to be community-acquired cases (p = 0.027). The unadjusted risk of six-month mortality was greater in the p-SAB group (14/31, 45.2%) compared to the m-SAB group (144/541, 26.6%) (HR = 1.94, 95% CI = 1.12–3.36, p = 0.018). After adjusting for relevant covariates, this difference approached significance (HR = 1.93, 95% = CI 0.96–3.87, p = 0.064). Conclusions: To our knowledge, the current investigation represents the only US population-based study evaluating p-SAB patients. We found lower incidence rates for p-SAB than previously reported, with almost one-half of the cases caused by Gram-positive bacteria. Furthermore, these patients had poor survival compared to incident m-SAB cases. MDPI 2022-12-08 /pmc/articles/PMC9784487/ /pubmed/36558831 http://dx.doi.org/10.3390/pathogens11121499 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hindy, Joya-Rita Quintero-Martinez, Juan A. Lahr, Brian D. DeSimone, Daniel C. Baddour, Larry M. A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia |
title | A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia |
title_full | A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia |
title_fullStr | A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia |
title_full_unstemmed | A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia |
title_short | A Population-Based Evaluation of Polymicrobial Staphylococcus aureus Bacteremia |
title_sort | population-based evaluation of polymicrobial staphylococcus aureus bacteremia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784487/ https://www.ncbi.nlm.nih.gov/pubmed/36558831 http://dx.doi.org/10.3390/pathogens11121499 |
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