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Cross-Species Translation of Biophase Half-Life and Potency of GalNAc-Conjugated siRNAs

Small interfering RNAs (siRNAs) with N-acetylgalactosamine (GalNAc) conjugation for improved liver uptake represent an emerging class of drugs to treat liver diseases. Understanding how pharmacokinetics and pharmacodynamics translate is pivotal for in vivo study design and human dose prediction. How...

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Detalles Bibliográficos
Autores principales:	Boianelli, Alessandro, Aoki, Yasunori, Ivanov, Maxim, Dahlén, Anders, Gennemark, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2022
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784597/ https://www.ncbi.nlm.nih.gov/pubmed/35867041 http://dx.doi.org/10.1089/nat.2022.0010

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