Cargando…

Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia

Schizophrenia (SCZ) is a severe brain disorder characterized by an intriguing clinical panel that has begun to gain interest due to its particular phenotype. Having considered the role of gut microflora in psychiatry, the latest discoveries might offer further insight into the underlying mechanisms....

Descripción completa

Detalles Bibliográficos
Autores principales: Nita, Ilinca-Bianca, Ilie, Ovidiu-Dumitru, Ciobica, Alin, Hritcu, Luminita-Diana, Dobrin, Irina, Doroftei, Bogdan, Dobrin, Romeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784651/
https://www.ncbi.nlm.nih.gov/pubmed/36555774
http://dx.doi.org/10.3390/ijms232416129
_version_ 1784857859953000448
author Nita, Ilinca-Bianca
Ilie, Ovidiu-Dumitru
Ciobica, Alin
Hritcu, Luminita-Diana
Dobrin, Irina
Doroftei, Bogdan
Dobrin, Romeo
author_facet Nita, Ilinca-Bianca
Ilie, Ovidiu-Dumitru
Ciobica, Alin
Hritcu, Luminita-Diana
Dobrin, Irina
Doroftei, Bogdan
Dobrin, Romeo
author_sort Nita, Ilinca-Bianca
collection PubMed
description Schizophrenia (SCZ) is a severe brain disorder characterized by an intriguing clinical panel that has begun to gain interest due to its particular phenotype. Having considered the role of gut microflora in psychiatry, the latest discoveries might offer further insight into the underlying mechanisms. Thus, we aimed to offer an updated overview of the therapeutic potential of microorganism-derived supplements alongside dedicated protocols that target the re-establishment of the host’s eubiosis. Based on combinations of specific keywords, we performed searches in four databases (PubMed/Medline, ISI Web of Knowledge, Scopus, and ScienceDirect) for the established interval (2018–2022) and identified twenty two eligible cases, restricted only to human patients’ experiences. Up until the writing of this manuscript, it has been revealed that the administration of specific lactic acid bacteria strains (Lactobacillus and Bifidobacterium), or those combined with vitamin D and selenium, maintain the integrity of the gut flora, preventing antagonistic effects including inflammation, antipsychotic-related body weight gain (olanzapine) and other metabolic dysfunctionalities. However, there are multiple antipsychotics that exert a potent effect upon gut flora, influencing a plethora of pathways and creating a dysbalance ratio between beneficial and opportunistic pathogens. Risperidone, amisulpride, and clozapine are just a few examples, but the current literature is unfortunately inconsistent and reported data is contradictory, which is why we support additional studies in this context. Moreover, we further argue the utility of studying how distinct controlled substances influence microbial communities, considering that ketamine is proved to alleviate depressive-like behavior as opposed to amphetamine and phencyclidine, which are known substances to trigger SCZ-like symptoms in experimental models. Probiotics may be regarded as the most consequential vehicle through which the gut flora can be successfully influenced, in adequate doses exerting a beneficial role as an alternative approach to alleviate SCZ symptoms.
format Online
Article
Text
id pubmed-9784651
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97846512022-12-24 Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia Nita, Ilinca-Bianca Ilie, Ovidiu-Dumitru Ciobica, Alin Hritcu, Luminita-Diana Dobrin, Irina Doroftei, Bogdan Dobrin, Romeo Int J Mol Sci Review Schizophrenia (SCZ) is a severe brain disorder characterized by an intriguing clinical panel that has begun to gain interest due to its particular phenotype. Having considered the role of gut microflora in psychiatry, the latest discoveries might offer further insight into the underlying mechanisms. Thus, we aimed to offer an updated overview of the therapeutic potential of microorganism-derived supplements alongside dedicated protocols that target the re-establishment of the host’s eubiosis. Based on combinations of specific keywords, we performed searches in four databases (PubMed/Medline, ISI Web of Knowledge, Scopus, and ScienceDirect) for the established interval (2018–2022) and identified twenty two eligible cases, restricted only to human patients’ experiences. Up until the writing of this manuscript, it has been revealed that the administration of specific lactic acid bacteria strains (Lactobacillus and Bifidobacterium), or those combined with vitamin D and selenium, maintain the integrity of the gut flora, preventing antagonistic effects including inflammation, antipsychotic-related body weight gain (olanzapine) and other metabolic dysfunctionalities. However, there are multiple antipsychotics that exert a potent effect upon gut flora, influencing a plethora of pathways and creating a dysbalance ratio between beneficial and opportunistic pathogens. Risperidone, amisulpride, and clozapine are just a few examples, but the current literature is unfortunately inconsistent and reported data is contradictory, which is why we support additional studies in this context. Moreover, we further argue the utility of studying how distinct controlled substances influence microbial communities, considering that ketamine is proved to alleviate depressive-like behavior as opposed to amphetamine and phencyclidine, which are known substances to trigger SCZ-like symptoms in experimental models. Probiotics may be regarded as the most consequential vehicle through which the gut flora can be successfully influenced, in adequate doses exerting a beneficial role as an alternative approach to alleviate SCZ symptoms. MDPI 2022-12-17 /pmc/articles/PMC9784651/ /pubmed/36555774 http://dx.doi.org/10.3390/ijms232416129 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nita, Ilinca-Bianca
Ilie, Ovidiu-Dumitru
Ciobica, Alin
Hritcu, Luminita-Diana
Dobrin, Irina
Doroftei, Bogdan
Dobrin, Romeo
Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia
title Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia
title_full Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia
title_fullStr Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia
title_full_unstemmed Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia
title_short Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia
title_sort reviewing the potential therapeutic approaches targeting the modulation of gastrointestinal microflora in schizophrenia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784651/
https://www.ncbi.nlm.nih.gov/pubmed/36555774
http://dx.doi.org/10.3390/ijms232416129
work_keys_str_mv AT nitailincabianca reviewingthepotentialtherapeuticapproachestargetingthemodulationofgastrointestinalmicroflorainschizophrenia
AT ilieovidiudumitru reviewingthepotentialtherapeuticapproachestargetingthemodulationofgastrointestinalmicroflorainschizophrenia
AT ciobicaalin reviewingthepotentialtherapeuticapproachestargetingthemodulationofgastrointestinalmicroflorainschizophrenia
AT hritculuminitadiana reviewingthepotentialtherapeuticapproachestargetingthemodulationofgastrointestinalmicroflorainschizophrenia
AT dobrinirina reviewingthepotentialtherapeuticapproachestargetingthemodulationofgastrointestinalmicroflorainschizophrenia
AT dorofteibogdan reviewingthepotentialtherapeuticapproachestargetingthemodulationofgastrointestinalmicroflorainschizophrenia
AT dobrinromeo reviewingthepotentialtherapeuticapproachestargetingthemodulationofgastrointestinalmicroflorainschizophrenia