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Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy

Melatonin, a naturally biosynthesized molecule secreted by the pineal gland, exhibits antitumor activities against several different types of cancer. The mechanisms of action of melatonin against tumor progression involve cellular apoptosis, antimetastatic activity, antioxidant and mutagenic effects...

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Detalles Bibliográficos
Autores principales: Hsiao, Sheng-Yen, Tang, Chih-Hsin, Chen, Po-Chun, Lin, Tien-Huang, Chao, Chia-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784694/
https://www.ncbi.nlm.nih.gov/pubmed/36557782
http://dx.doi.org/10.3390/molecules27248649
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author Hsiao, Sheng-Yen
Tang, Chih-Hsin
Chen, Po-Chun
Lin, Tien-Huang
Chao, Chia-Chia
author_facet Hsiao, Sheng-Yen
Tang, Chih-Hsin
Chen, Po-Chun
Lin, Tien-Huang
Chao, Chia-Chia
author_sort Hsiao, Sheng-Yen
collection PubMed
description Melatonin, a naturally biosynthesized molecule secreted by the pineal gland, exhibits antitumor activities against several different types of cancer. The mechanisms of action of melatonin against tumor progression involve cellular apoptosis, antimetastatic activity, antioxidant and mutagenic effects, antiangiogenic activity, and the restoration of cancer immune surveillance. Melatonin has anticancer activity when administered alone or in combination with standard chemotherapeutic agents, with measurable improvements seen in the clinical endpoints of tumor regression and patient survival. However, scant clinical evidence supports the use of melatonin in bladder cancer treatment. Our study has found that melatonin treatment suppresses the bladder cancer cell migratory ability by inhibiting the epithelial-mesenchymal transition (EMT) process, which appears to be linked to melatonin-induced decreases in bladder cancer cell autophagy. Finally, an evaluation of in vivo melatonin-induced antitumor effects in an orthotopic animal model of bladder cancer indicated that melatonin treatment slightly prolonged the survival of tumor-bearing mice. Our study offers novel insights into the use of melatonin in bladder cancer treatment.
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spelling pubmed-97846942022-12-24 Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy Hsiao, Sheng-Yen Tang, Chih-Hsin Chen, Po-Chun Lin, Tien-Huang Chao, Chia-Chia Molecules Article Melatonin, a naturally biosynthesized molecule secreted by the pineal gland, exhibits antitumor activities against several different types of cancer. The mechanisms of action of melatonin against tumor progression involve cellular apoptosis, antimetastatic activity, antioxidant and mutagenic effects, antiangiogenic activity, and the restoration of cancer immune surveillance. Melatonin has anticancer activity when administered alone or in combination with standard chemotherapeutic agents, with measurable improvements seen in the clinical endpoints of tumor regression and patient survival. However, scant clinical evidence supports the use of melatonin in bladder cancer treatment. Our study has found that melatonin treatment suppresses the bladder cancer cell migratory ability by inhibiting the epithelial-mesenchymal transition (EMT) process, which appears to be linked to melatonin-induced decreases in bladder cancer cell autophagy. Finally, an evaluation of in vivo melatonin-induced antitumor effects in an orthotopic animal model of bladder cancer indicated that melatonin treatment slightly prolonged the survival of tumor-bearing mice. Our study offers novel insights into the use of melatonin in bladder cancer treatment. MDPI 2022-12-07 /pmc/articles/PMC9784694/ /pubmed/36557782 http://dx.doi.org/10.3390/molecules27248649 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsiao, Sheng-Yen
Tang, Chih-Hsin
Chen, Po-Chun
Lin, Tien-Huang
Chao, Chia-Chia
Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy
title Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy
title_full Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy
title_fullStr Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy
title_full_unstemmed Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy
title_short Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy
title_sort melatonin inhibits emt in bladder cancer by targeting autophagy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784694/
https://www.ncbi.nlm.nih.gov/pubmed/36557782
http://dx.doi.org/10.3390/molecules27248649
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