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Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation

Objective: Despite improvements in the technology of catheter ablation of atrial fibrillation (AF), recurrences are still a major problem, even after a successful procedure. The uric acid/albumin ratio (UAR), which is an inexpensive and simple laboratory parameter, has recently been introduced in th...

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Autores principales: Karataş, Mehmet Baran, Durmuş, Gündüz, Zengin, Ahmet, Gökalp, Murat, Hayıroğlu, Mert İlker, Çınar, Tufan, Gürkan, Kadir, Çam, Neşe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784806/
https://www.ncbi.nlm.nih.gov/pubmed/36557074
http://dx.doi.org/10.3390/medicina58121872
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author Karataş, Mehmet Baran
Durmuş, Gündüz
Zengin, Ahmet
Gökalp, Murat
Hayıroğlu, Mert İlker
Çınar, Tufan
Gürkan, Kadir
Çam, Neşe
author_facet Karataş, Mehmet Baran
Durmuş, Gündüz
Zengin, Ahmet
Gökalp, Murat
Hayıroğlu, Mert İlker
Çınar, Tufan
Gürkan, Kadir
Çam, Neşe
author_sort Karataş, Mehmet Baran
collection PubMed
description Objective: Despite improvements in the technology of catheter ablation of atrial fibrillation (AF), recurrences are still a major problem, even after a successful procedure. The uric acid/albumin ratio (UAR), which is an inexpensive and simple laboratory parameter, has recently been introduced in the literature as a predictor of adverse cardiovascular events. Hence, we aimed to investigate the relationship between the UAR and AF recurrence after catheter ablation. Methods: A total of 170 patients who underwent successful catheter ablation for AF were included. The primary outcome was the late recurrence after treatment. The recurrence (+) and recurrence (−) groups were compared for clinical, laboratory and procedural characteristics as well as the predictors of recurrence assessed by regression analysis. Results: In our study population, 53 (26%) patients developed AF recurrence after catheter ablation. Mean UAR was higher in the recurrence (+) group compared to recurrence (−) group (2.4 ± 0.9 vs. 1.8 ± 0.7, p < 0.01). In multivariable regression analysis, left atrial diameter (HR: 1.08, 95% CI: 1.01–1.16, p = 0.01) and UAR (HR:1.36, 95% CI: 1.06–1.75, p = 0.01) were found to be independent predictors of recurrence. In ROC analysis, the UAR > 1.67 predicted recurrence with a sensitivity of 77% and a specificity of 57% (AUC 0.68, p < 0.01). Conclusion: For the first time in the literature, the UAR were found to be correlated independently with AF recurrence after catheter ablation.
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spelling pubmed-97848062022-12-24 Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation Karataş, Mehmet Baran Durmuş, Gündüz Zengin, Ahmet Gökalp, Murat Hayıroğlu, Mert İlker Çınar, Tufan Gürkan, Kadir Çam, Neşe Medicina (Kaunas) Article Objective: Despite improvements in the technology of catheter ablation of atrial fibrillation (AF), recurrences are still a major problem, even after a successful procedure. The uric acid/albumin ratio (UAR), which is an inexpensive and simple laboratory parameter, has recently been introduced in the literature as a predictor of adverse cardiovascular events. Hence, we aimed to investigate the relationship between the UAR and AF recurrence after catheter ablation. Methods: A total of 170 patients who underwent successful catheter ablation for AF were included. The primary outcome was the late recurrence after treatment. The recurrence (+) and recurrence (−) groups were compared for clinical, laboratory and procedural characteristics as well as the predictors of recurrence assessed by regression analysis. Results: In our study population, 53 (26%) patients developed AF recurrence after catheter ablation. Mean UAR was higher in the recurrence (+) group compared to recurrence (−) group (2.4 ± 0.9 vs. 1.8 ± 0.7, p < 0.01). In multivariable regression analysis, left atrial diameter (HR: 1.08, 95% CI: 1.01–1.16, p = 0.01) and UAR (HR:1.36, 95% CI: 1.06–1.75, p = 0.01) were found to be independent predictors of recurrence. In ROC analysis, the UAR > 1.67 predicted recurrence with a sensitivity of 77% and a specificity of 57% (AUC 0.68, p < 0.01). Conclusion: For the first time in the literature, the UAR were found to be correlated independently with AF recurrence after catheter ablation. MDPI 2022-12-19 /pmc/articles/PMC9784806/ /pubmed/36557074 http://dx.doi.org/10.3390/medicina58121872 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karataş, Mehmet Baran
Durmuş, Gündüz
Zengin, Ahmet
Gökalp, Murat
Hayıroğlu, Mert İlker
Çınar, Tufan
Gürkan, Kadir
Çam, Neşe
Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation
title Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation
title_full Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation
title_fullStr Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation
title_full_unstemmed Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation
title_short Association of Uric Acid Albumin Ratio with Recurrence of Atrial Fibrillation after Cryoballoon Catheter Ablation
title_sort association of uric acid albumin ratio with recurrence of atrial fibrillation after cryoballoon catheter ablation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784806/
https://www.ncbi.nlm.nih.gov/pubmed/36557074
http://dx.doi.org/10.3390/medicina58121872
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