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Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia

This study investigated the relationship between the severity of pneumonia based on chest CT findings and that of pancreatic steatosis assessed using an automated volumetric measurement of the CT fat volume fraction (CT-FVF) of the pancreas, using unenhanced three-dimensional CT in polymerase chain...

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Autores principales: Tanabe, Masahiro, Kunihiro, Yoshie, Higashi, Mayumi, Ihara, Kenichiro, Tanabe, Masaya, Yagi, Takeshi, Kobayashi, Taiga, Ueda, Takaaki, Ito, Katsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784887/
https://www.ncbi.nlm.nih.gov/pubmed/36548526
http://dx.doi.org/10.3390/tomography8060234
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author Tanabe, Masahiro
Kunihiro, Yoshie
Higashi, Mayumi
Ihara, Kenichiro
Tanabe, Masaya
Yagi, Takeshi
Kobayashi, Taiga
Ueda, Takaaki
Ito, Katsuyoshi
author_facet Tanabe, Masahiro
Kunihiro, Yoshie
Higashi, Mayumi
Ihara, Kenichiro
Tanabe, Masaya
Yagi, Takeshi
Kobayashi, Taiga
Ueda, Takaaki
Ito, Katsuyoshi
author_sort Tanabe, Masahiro
collection PubMed
description This study investigated the relationship between the severity of pneumonia based on chest CT findings and that of pancreatic steatosis assessed using an automated volumetric measurement of the CT fat volume fraction (CT-FVF) of the pancreas, using unenhanced three-dimensional CT in polymerase chain reaction (PCR)-confirmed COVID-19 patients. The study population consisted of 128 patients with PCR-confirmed COVID-19 infection who underwent CT examinations. The CT-FVF of the pancreas was calculated using a histogram analysis for the isolation of fat-containing voxels in the pancreas. The CT-FVF (%) of the pancreas had a significantly positive correlation with the lung severity score on CT (ρ = 0.549, p < 0.01). CT-FVF (%) of the pancreas in the severe pneumonia group was significantly higher than that of the non-severe pneumonia group (21.7% vs. 7.8%, p < 0.01). The area under the curve of CT-FVF (%) of the pancreas in predicting the severity of pneumonia on CT was calculated to be 0.82, with a sensitivity of 88% and a specificity of 68% at a threshold for the severity score of 12.3. The automated volumetric measurement of the CT-FVF of the pancreas using unenhanced CT can help estimate disease severity in patients with COVID-19 pneumonia based on chest CT findings.
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spelling pubmed-97848872022-12-24 Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia Tanabe, Masahiro Kunihiro, Yoshie Higashi, Mayumi Ihara, Kenichiro Tanabe, Masaya Yagi, Takeshi Kobayashi, Taiga Ueda, Takaaki Ito, Katsuyoshi Tomography Article This study investigated the relationship between the severity of pneumonia based on chest CT findings and that of pancreatic steatosis assessed using an automated volumetric measurement of the CT fat volume fraction (CT-FVF) of the pancreas, using unenhanced three-dimensional CT in polymerase chain reaction (PCR)-confirmed COVID-19 patients. The study population consisted of 128 patients with PCR-confirmed COVID-19 infection who underwent CT examinations. The CT-FVF of the pancreas was calculated using a histogram analysis for the isolation of fat-containing voxels in the pancreas. The CT-FVF (%) of the pancreas had a significantly positive correlation with the lung severity score on CT (ρ = 0.549, p < 0.01). CT-FVF (%) of the pancreas in the severe pneumonia group was significantly higher than that of the non-severe pneumonia group (21.7% vs. 7.8%, p < 0.01). The area under the curve of CT-FVF (%) of the pancreas in predicting the severity of pneumonia on CT was calculated to be 0.82, with a sensitivity of 88% and a specificity of 68% at a threshold for the severity score of 12.3. The automated volumetric measurement of the CT-FVF of the pancreas using unenhanced CT can help estimate disease severity in patients with COVID-19 pneumonia based on chest CT findings. MDPI 2022-11-24 /pmc/articles/PMC9784887/ /pubmed/36548526 http://dx.doi.org/10.3390/tomography8060234 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tanabe, Masahiro
Kunihiro, Yoshie
Higashi, Mayumi
Ihara, Kenichiro
Tanabe, Masaya
Yagi, Takeshi
Kobayashi, Taiga
Ueda, Takaaki
Ito, Katsuyoshi
Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia
title Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia
title_full Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia
title_fullStr Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia
title_full_unstemmed Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia
title_short Pancreatic Steatosis Evaluated by Automated Volumetric CT Fat Fraction of the Pancreas: Association with Severity in COVID-19 Pneumonia
title_sort pancreatic steatosis evaluated by automated volumetric ct fat fraction of the pancreas: association with severity in covid-19 pneumonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784887/
https://www.ncbi.nlm.nih.gov/pubmed/36548526
http://dx.doi.org/10.3390/tomography8060234
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