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COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample

Venous thromboembolism, in particular, pulmonary embolism (PE), is a significant contributor to the morbidity and mortality associated with COVID-19. In this study, we utilized the National Inpatient Sample (NIS) database 2020 to evaluate and compare clinical outcomes in patients with COVID-19 with...

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Autores principales: Nasrullah, Adeel, Gangu, Karthik, Shumway, Nichole B., Cannon, Harmon R., Garg, Ishan, Shuja, Hina, Bobba, Aniesh, Chourasia, Prabal, Sheikh, Abu Baker, Shekhar, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784895/
https://www.ncbi.nlm.nih.gov/pubmed/36560514
http://dx.doi.org/10.3390/vaccines10122104
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author Nasrullah, Adeel
Gangu, Karthik
Shumway, Nichole B.
Cannon, Harmon R.
Garg, Ishan
Shuja, Hina
Bobba, Aniesh
Chourasia, Prabal
Sheikh, Abu Baker
Shekhar, Rahul
author_facet Nasrullah, Adeel
Gangu, Karthik
Shumway, Nichole B.
Cannon, Harmon R.
Garg, Ishan
Shuja, Hina
Bobba, Aniesh
Chourasia, Prabal
Sheikh, Abu Baker
Shekhar, Rahul
author_sort Nasrullah, Adeel
collection PubMed
description Venous thromboembolism, in particular, pulmonary embolism (PE), is a significant contributor to the morbidity and mortality associated with COVID-19. In this study, we utilized the National Inpatient Sample (NIS) database 2020 to evaluate and compare clinical outcomes in patients with COVID-19 with and without PE. Our sample includes 1,659,040 patients hospitalized with COVID-19 pneumonia between January 2020 and December 2020. We performed propensity-matched analysis for patient characteristics and in-hospital outcomes, including the patient’s age, race, sex, insurance status, median income, length of stay, mortality, hospitalization cost, comorbidities, mechanical ventilation, and vasopressor support. Patients with COVID-19 with PE had a higher need for mechanical ventilation (25.7% vs. 15.6%, adjusted odds ratio 1.4, 95% CI 1.4–1.5, p < 0.001), the vasopressor requirement (5.4% vs. 2.6%, adjusted OR 1.6, 95% CI 1.4–1.8, p < 0.001), longer hospital stays (10.8 vs. 7.9 days, p < 0.001), and overall higher in-hospital mortality (19.1 vs. 13.9%, adjusted OR of 1.3, 95% CI 1.1–1.5, p < 0.001). This study highlights the need for more aggressive management of PE in COVID-19-positive patients with the aim to improve early diagnosis and treatment to reduce morbidity, mortality, and healthcare costs seen in the synchronous COVID-19 and PE-positive patients.
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spelling pubmed-97848952022-12-24 COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample Nasrullah, Adeel Gangu, Karthik Shumway, Nichole B. Cannon, Harmon R. Garg, Ishan Shuja, Hina Bobba, Aniesh Chourasia, Prabal Sheikh, Abu Baker Shekhar, Rahul Vaccines (Basel) Article Venous thromboembolism, in particular, pulmonary embolism (PE), is a significant contributor to the morbidity and mortality associated with COVID-19. In this study, we utilized the National Inpatient Sample (NIS) database 2020 to evaluate and compare clinical outcomes in patients with COVID-19 with and without PE. Our sample includes 1,659,040 patients hospitalized with COVID-19 pneumonia between January 2020 and December 2020. We performed propensity-matched analysis for patient characteristics and in-hospital outcomes, including the patient’s age, race, sex, insurance status, median income, length of stay, mortality, hospitalization cost, comorbidities, mechanical ventilation, and vasopressor support. Patients with COVID-19 with PE had a higher need for mechanical ventilation (25.7% vs. 15.6%, adjusted odds ratio 1.4, 95% CI 1.4–1.5, p < 0.001), the vasopressor requirement (5.4% vs. 2.6%, adjusted OR 1.6, 95% CI 1.4–1.8, p < 0.001), longer hospital stays (10.8 vs. 7.9 days, p < 0.001), and overall higher in-hospital mortality (19.1 vs. 13.9%, adjusted OR of 1.3, 95% CI 1.1–1.5, p < 0.001). This study highlights the need for more aggressive management of PE in COVID-19-positive patients with the aim to improve early diagnosis and treatment to reduce morbidity, mortality, and healthcare costs seen in the synchronous COVID-19 and PE-positive patients. MDPI 2022-12-08 /pmc/articles/PMC9784895/ /pubmed/36560514 http://dx.doi.org/10.3390/vaccines10122104 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nasrullah, Adeel
Gangu, Karthik
Shumway, Nichole B.
Cannon, Harmon R.
Garg, Ishan
Shuja, Hina
Bobba, Aniesh
Chourasia, Prabal
Sheikh, Abu Baker
Shekhar, Rahul
COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample
title COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample
title_full COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample
title_fullStr COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample
title_full_unstemmed COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample
title_short COVID-19 and Pulmonary Embolism Outcomes among Hospitalized Patients in the United States: A Propensity-Matched Analysis of National Inpatient Sample
title_sort covid-19 and pulmonary embolism outcomes among hospitalized patients in the united states: a propensity-matched analysis of national inpatient sample
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784895/
https://www.ncbi.nlm.nih.gov/pubmed/36560514
http://dx.doi.org/10.3390/vaccines10122104
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