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Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study

The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status...

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Autores principales: Tomiyama, Takahiro, Harada, Noboru, Toshima, Takeo, Nakayama, Yuki, Toshida, Katsuya, Morinaga, Akinari, Kosai-Fujimoto, Yukiko, Tomino, Takahiro, Kurihara, Takeshi, Takeishi, Kazuki, Nagao, Yoshihiro, Morita, Kazutoyo, Itoh, Shinji, Yoshizumi, Tomoharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784912/
https://www.ncbi.nlm.nih.gov/pubmed/36568139
http://dx.doi.org/10.3389/ti.2022.10723
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author Tomiyama, Takahiro
Harada, Noboru
Toshima, Takeo
Nakayama, Yuki
Toshida, Katsuya
Morinaga, Akinari
Kosai-Fujimoto, Yukiko
Tomino, Takahiro
Kurihara, Takeshi
Takeishi, Kazuki
Nagao, Yoshihiro
Morita, Kazutoyo
Itoh, Shinji
Yoshizumi, Tomoharu
author_facet Tomiyama, Takahiro
Harada, Noboru
Toshima, Takeo
Nakayama, Yuki
Toshida, Katsuya
Morinaga, Akinari
Kosai-Fujimoto, Yukiko
Tomino, Takahiro
Kurihara, Takeshi
Takeishi, Kazuki
Nagao, Yoshihiro
Morita, Kazutoyo
Itoh, Shinji
Yoshizumi, Tomoharu
author_sort Tomiyama, Takahiro
collection PubMed
description The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status and graft function. We measured the skeletal muscle mass index (SMI) and intramuscular adipose tissue content (IMAC) of 380 LDLT donors. We examined the correlation between donor SMI or IMAC and graft mortality, the occurrence rates of small-for-size graft (SFSG) syndrome, and 6-month graft survival rates. The donor SMI had no effect on the occurrence of SFSG syndrome and graft survival, while a high IMAC in both male and female donors was significantly correlated with the rate of SFSG syndrome [high vs low: (male donors) 15.8% vs. 2.5%, p = 0.0003; (female donors) 12.8% vs. 3.1%, p = 0.0234] and 6-month graft survival rates [(male donors) 87.7% vs 95.9%, p = 0.02; (female donors) 83.0% vs. 99.0%, p < 0.0001]. Multivariate analysis revealed that a high donor IMAC (HR; 5.42, CI; 2.13–13.8, p = 0.0004) was an independent risk factor for 6-month graft survival, and the donor IMAC is useful for donor selection for high-risk recipients.
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spelling pubmed-97849122022-12-24 Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study Tomiyama, Takahiro Harada, Noboru Toshima, Takeo Nakayama, Yuki Toshida, Katsuya Morinaga, Akinari Kosai-Fujimoto, Yukiko Tomino, Takahiro Kurihara, Takeshi Takeishi, Kazuki Nagao, Yoshihiro Morita, Kazutoyo Itoh, Shinji Yoshizumi, Tomoharu Transpl Int Health Archive The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status and graft function. We measured the skeletal muscle mass index (SMI) and intramuscular adipose tissue content (IMAC) of 380 LDLT donors. We examined the correlation between donor SMI or IMAC and graft mortality, the occurrence rates of small-for-size graft (SFSG) syndrome, and 6-month graft survival rates. The donor SMI had no effect on the occurrence of SFSG syndrome and graft survival, while a high IMAC in both male and female donors was significantly correlated with the rate of SFSG syndrome [high vs low: (male donors) 15.8% vs. 2.5%, p = 0.0003; (female donors) 12.8% vs. 3.1%, p = 0.0234] and 6-month graft survival rates [(male donors) 87.7% vs 95.9%, p = 0.02; (female donors) 83.0% vs. 99.0%, p < 0.0001]. Multivariate analysis revealed that a high donor IMAC (HR; 5.42, CI; 2.13–13.8, p = 0.0004) was an independent risk factor for 6-month graft survival, and the donor IMAC is useful for donor selection for high-risk recipients. Frontiers Media S.A. 2022-12-09 /pmc/articles/PMC9784912/ /pubmed/36568139 http://dx.doi.org/10.3389/ti.2022.10723 Text en Copyright © 2022 Tomiyama, Harada, Toshima, Nakayama, Toshida, Morinaga, Kosai-Fujimoto, Tomino, Kurihara, Takeishi, Nagao, Morita, Itoh and Yoshizumi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Tomiyama, Takahiro
Harada, Noboru
Toshima, Takeo
Nakayama, Yuki
Toshida, Katsuya
Morinaga, Akinari
Kosai-Fujimoto, Yukiko
Tomino, Takahiro
Kurihara, Takeshi
Takeishi, Kazuki
Nagao, Yoshihiro
Morita, Kazutoyo
Itoh, Shinji
Yoshizumi, Tomoharu
Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
title Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
title_full Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
title_fullStr Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
title_full_unstemmed Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
title_short Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
title_sort donor skeletal muscle quality affects graft mortality after living donor liver transplantation- a single center, retrospective study
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784912/
https://www.ncbi.nlm.nih.gov/pubmed/36568139
http://dx.doi.org/10.3389/ti.2022.10723
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