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Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study
The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784912/ https://www.ncbi.nlm.nih.gov/pubmed/36568139 http://dx.doi.org/10.3389/ti.2022.10723 |
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author | Tomiyama, Takahiro Harada, Noboru Toshima, Takeo Nakayama, Yuki Toshida, Katsuya Morinaga, Akinari Kosai-Fujimoto, Yukiko Tomino, Takahiro Kurihara, Takeshi Takeishi, Kazuki Nagao, Yoshihiro Morita, Kazutoyo Itoh, Shinji Yoshizumi, Tomoharu |
author_facet | Tomiyama, Takahiro Harada, Noboru Toshima, Takeo Nakayama, Yuki Toshida, Katsuya Morinaga, Akinari Kosai-Fujimoto, Yukiko Tomino, Takahiro Kurihara, Takeshi Takeishi, Kazuki Nagao, Yoshihiro Morita, Kazutoyo Itoh, Shinji Yoshizumi, Tomoharu |
author_sort | Tomiyama, Takahiro |
collection | PubMed |
description | The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status and graft function. We measured the skeletal muscle mass index (SMI) and intramuscular adipose tissue content (IMAC) of 380 LDLT donors. We examined the correlation between donor SMI or IMAC and graft mortality, the occurrence rates of small-for-size graft (SFSG) syndrome, and 6-month graft survival rates. The donor SMI had no effect on the occurrence of SFSG syndrome and graft survival, while a high IMAC in both male and female donors was significantly correlated with the rate of SFSG syndrome [high vs low: (male donors) 15.8% vs. 2.5%, p = 0.0003; (female donors) 12.8% vs. 3.1%, p = 0.0234] and 6-month graft survival rates [(male donors) 87.7% vs 95.9%, p = 0.02; (female donors) 83.0% vs. 99.0%, p < 0.0001]. Multivariate analysis revealed that a high donor IMAC (HR; 5.42, CI; 2.13–13.8, p = 0.0004) was an independent risk factor for 6-month graft survival, and the donor IMAC is useful for donor selection for high-risk recipients. |
format | Online Article Text |
id | pubmed-9784912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97849122022-12-24 Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study Tomiyama, Takahiro Harada, Noboru Toshima, Takeo Nakayama, Yuki Toshida, Katsuya Morinaga, Akinari Kosai-Fujimoto, Yukiko Tomino, Takahiro Kurihara, Takeshi Takeishi, Kazuki Nagao, Yoshihiro Morita, Kazutoyo Itoh, Shinji Yoshizumi, Tomoharu Transpl Int Health Archive The recipient muscle status is closely associated with postoperative poor survival in recipients of living donor liver transplantation (LDLT). However, it is uncertain whether LDLT donor muscle quality and quantity affect graft quality. Hence, we analyzed the correlation between donor muscle status and graft function. We measured the skeletal muscle mass index (SMI) and intramuscular adipose tissue content (IMAC) of 380 LDLT donors. We examined the correlation between donor SMI or IMAC and graft mortality, the occurrence rates of small-for-size graft (SFSG) syndrome, and 6-month graft survival rates. The donor SMI had no effect on the occurrence of SFSG syndrome and graft survival, while a high IMAC in both male and female donors was significantly correlated with the rate of SFSG syndrome [high vs low: (male donors) 15.8% vs. 2.5%, p = 0.0003; (female donors) 12.8% vs. 3.1%, p = 0.0234] and 6-month graft survival rates [(male donors) 87.7% vs 95.9%, p = 0.02; (female donors) 83.0% vs. 99.0%, p < 0.0001]. Multivariate analysis revealed that a high donor IMAC (HR; 5.42, CI; 2.13–13.8, p = 0.0004) was an independent risk factor for 6-month graft survival, and the donor IMAC is useful for donor selection for high-risk recipients. Frontiers Media S.A. 2022-12-09 /pmc/articles/PMC9784912/ /pubmed/36568139 http://dx.doi.org/10.3389/ti.2022.10723 Text en Copyright © 2022 Tomiyama, Harada, Toshima, Nakayama, Toshida, Morinaga, Kosai-Fujimoto, Tomino, Kurihara, Takeishi, Nagao, Morita, Itoh and Yoshizumi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Tomiyama, Takahiro Harada, Noboru Toshima, Takeo Nakayama, Yuki Toshida, Katsuya Morinaga, Akinari Kosai-Fujimoto, Yukiko Tomino, Takahiro Kurihara, Takeshi Takeishi, Kazuki Nagao, Yoshihiro Morita, Kazutoyo Itoh, Shinji Yoshizumi, Tomoharu Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study |
title | Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study |
title_full | Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study |
title_fullStr | Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study |
title_full_unstemmed | Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study |
title_short | Donor Skeletal Muscle Quality Affects Graft Mortality After Living Donor Liver Transplantation- A Single Center, Retrospective Study |
title_sort | donor skeletal muscle quality affects graft mortality after living donor liver transplantation- a single center, retrospective study |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784912/ https://www.ncbi.nlm.nih.gov/pubmed/36568139 http://dx.doi.org/10.3389/ti.2022.10723 |
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