Novel Small Molecule Positive Allosteric Modulator SPAM1 Triggers the Nuclear Translocation of PAC1-R to Exert Neuroprotective Effects through Neuron-Restrictive Silencer Factor

The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) exerts effective neuroprotective activity through its specific receptor, PAC1-R. We accidentally discovered that as a positive allosteric modulator (PAM) of PAC1-R, the small-molecule PAM (SPAM1) has a hydrazide-like structu...

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Detalles Bibliográficos
Autores principales: Fan, Guangchun, Chen, Shang, Liang, Lili, Zhang, Huahua, Yu, Rongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784932/
https://www.ncbi.nlm.nih.gov/pubmed/36555637
http://dx.doi.org/10.3390/ijms232415996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784932/
https://www.ncbi.nlm.nih.gov/pubmed/36555637
http://dx.doi.org/10.3390/ijms232415996

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