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Plant Nanovesicles for Essential Oil Delivery

Essential oils’ therapeutic potential is highly recognized, with many applications rising due to reported anti-inflammatory, cardioprotective, neuroprotective, anti-aging, and anti-cancer effects. Nevertheless, clinical translation still remains a challenge, mainly due to essential oils’ volatility...

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Autores principales: Zuzarte, Mónica, Vitorino, Carla, Salgueiro, Lígia, Girão, Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784947/
https://www.ncbi.nlm.nih.gov/pubmed/36559075
http://dx.doi.org/10.3390/pharmaceutics14122581
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author Zuzarte, Mónica
Vitorino, Carla
Salgueiro, Lígia
Girão, Henrique
author_facet Zuzarte, Mónica
Vitorino, Carla
Salgueiro, Lígia
Girão, Henrique
author_sort Zuzarte, Mónica
collection PubMed
description Essential oils’ therapeutic potential is highly recognized, with many applications rising due to reported anti-inflammatory, cardioprotective, neuroprotective, anti-aging, and anti-cancer effects. Nevertheless, clinical translation still remains a challenge, mainly due to essential oils’ volatility and low water solubility and stability. The present review gathers relevant information and postulates on the potential application of plant nanovesicles to effectively deliver essential oils to target organs. Indeed, plant nanovesicles are emerging as alternatives to mammalian vesicles and synthetic carriers due to their safety, stability, non-toxicity, and low immunogenicity. Moreover, they can be produced on a large scale from various plant parts, enabling an easier, more rapid, and less costly industrial application that could add value to waste products and boost the circular economy. Importantly, the use of plant nanovesicles as delivery platforms could increase essential oils’ bioavailability and improve chemical stability while reducing volatility and toxicity issues. Additionally, using targeting strategies, essential oils’ selectivity, drug delivery, and efficacy could be improved, ultimately leading to dose reduction and patient compliance. Bearing this in mind, information on current pharmaceutical technologies available to enable distinct routes of administration of loaded vesicles is also discussed.
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spelling pubmed-97849472022-12-24 Plant Nanovesicles for Essential Oil Delivery Zuzarte, Mónica Vitorino, Carla Salgueiro, Lígia Girão, Henrique Pharmaceutics Review Essential oils’ therapeutic potential is highly recognized, with many applications rising due to reported anti-inflammatory, cardioprotective, neuroprotective, anti-aging, and anti-cancer effects. Nevertheless, clinical translation still remains a challenge, mainly due to essential oils’ volatility and low water solubility and stability. The present review gathers relevant information and postulates on the potential application of plant nanovesicles to effectively deliver essential oils to target organs. Indeed, plant nanovesicles are emerging as alternatives to mammalian vesicles and synthetic carriers due to their safety, stability, non-toxicity, and low immunogenicity. Moreover, they can be produced on a large scale from various plant parts, enabling an easier, more rapid, and less costly industrial application that could add value to waste products and boost the circular economy. Importantly, the use of plant nanovesicles as delivery platforms could increase essential oils’ bioavailability and improve chemical stability while reducing volatility and toxicity issues. Additionally, using targeting strategies, essential oils’ selectivity, drug delivery, and efficacy could be improved, ultimately leading to dose reduction and patient compliance. Bearing this in mind, information on current pharmaceutical technologies available to enable distinct routes of administration of loaded vesicles is also discussed. MDPI 2022-11-24 /pmc/articles/PMC9784947/ /pubmed/36559075 http://dx.doi.org/10.3390/pharmaceutics14122581 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zuzarte, Mónica
Vitorino, Carla
Salgueiro, Lígia
Girão, Henrique
Plant Nanovesicles for Essential Oil Delivery
title Plant Nanovesicles for Essential Oil Delivery
title_full Plant Nanovesicles for Essential Oil Delivery
title_fullStr Plant Nanovesicles for Essential Oil Delivery
title_full_unstemmed Plant Nanovesicles for Essential Oil Delivery
title_short Plant Nanovesicles for Essential Oil Delivery
title_sort plant nanovesicles for essential oil delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784947/
https://www.ncbi.nlm.nih.gov/pubmed/36559075
http://dx.doi.org/10.3390/pharmaceutics14122581
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