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Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment

Cannabis sativa is one of the first medicinal plants used by humans. Its medical use remains controversial because it is a psychotropic drug whose use has been banned. Recently, however, some countries have approved its use, including for recreational and medical purposes, and have allowed the scien...

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Autores principales: Pérez, Rebeca, Glaser, Talita, Villegas, Cecilia, Burgos, Viviana, Ulrich, Henning, Paz, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784976/
https://www.ncbi.nlm.nih.gov/pubmed/36556483
http://dx.doi.org/10.3390/life12122117
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author Pérez, Rebeca
Glaser, Talita
Villegas, Cecilia
Burgos, Viviana
Ulrich, Henning
Paz, Cristian
author_facet Pérez, Rebeca
Glaser, Talita
Villegas, Cecilia
Burgos, Viviana
Ulrich, Henning
Paz, Cristian
author_sort Pérez, Rebeca
collection PubMed
description Cannabis sativa is one of the first medicinal plants used by humans. Its medical use remains controversial because it is a psychotropic drug whose use has been banned. Recently, however, some countries have approved its use, including for recreational and medical purposes, and have allowed the scientific study of its compounds. Cannabis is characterized by the production of special types of natural products called phytocannabinoids that are synthesized exclusively by this genus. Phytocannabinoids and endocannabinoids are chemically different, but both pharmacologically modulate CB1, CB2, GRP55, GRP119 and TRPV1 receptor activities, involving activities such as memory, sleep, mood, appetite and motor regulation, pain sensation, neuroinflammation, neurogenesis and apoptosis. Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are phytocannabinoids with greater pharmacological potential, including anti-inflammatory, neuroprotective and anticonvulsant activities. Cannabidiol is showing promising results for the treatment of COVID-19, due to its capability of acting on the unleashed cytokine storm, on the proteins necessary for both virus entry and replication and on the neurological consequences of patients who have been infected by the virus. Here, we summarize the latest knowledge regarding the advantages of using cannabinoids in the treatment of COVID-19.
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spelling pubmed-97849762022-12-24 Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment Pérez, Rebeca Glaser, Talita Villegas, Cecilia Burgos, Viviana Ulrich, Henning Paz, Cristian Life (Basel) Review Cannabis sativa is one of the first medicinal plants used by humans. Its medical use remains controversial because it is a psychotropic drug whose use has been banned. Recently, however, some countries have approved its use, including for recreational and medical purposes, and have allowed the scientific study of its compounds. Cannabis is characterized by the production of special types of natural products called phytocannabinoids that are synthesized exclusively by this genus. Phytocannabinoids and endocannabinoids are chemically different, but both pharmacologically modulate CB1, CB2, GRP55, GRP119 and TRPV1 receptor activities, involving activities such as memory, sleep, mood, appetite and motor regulation, pain sensation, neuroinflammation, neurogenesis and apoptosis. Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are phytocannabinoids with greater pharmacological potential, including anti-inflammatory, neuroprotective and anticonvulsant activities. Cannabidiol is showing promising results for the treatment of COVID-19, due to its capability of acting on the unleashed cytokine storm, on the proteins necessary for both virus entry and replication and on the neurological consequences of patients who have been infected by the virus. Here, we summarize the latest knowledge regarding the advantages of using cannabinoids in the treatment of COVID-19. MDPI 2022-12-15 /pmc/articles/PMC9784976/ /pubmed/36556483 http://dx.doi.org/10.3390/life12122117 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pérez, Rebeca
Glaser, Talita
Villegas, Cecilia
Burgos, Viviana
Ulrich, Henning
Paz, Cristian
Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment
title Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment
title_full Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment
title_fullStr Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment
title_full_unstemmed Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment
title_short Therapeutic Effects of Cannabinoids and Their Applications in COVID-19 Treatment
title_sort therapeutic effects of cannabinoids and their applications in covid-19 treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784976/
https://www.ncbi.nlm.nih.gov/pubmed/36556483
http://dx.doi.org/10.3390/life12122117
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