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Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis

Background: Vitamin D level has been reported to be associated with psoriasis, atopic dermatitis, and vitiligo. However, its causal relationship with the risk of these three diseases remains unclear. Methods: We obtained genome-wide association statistics for three measures of circulating vitamin D...

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Autores principales: Ren, Yunqing, Liu, Jipeng, Li, Wei, Zheng, Huiwen, Dai, Huatuo, Qiu, Guiying, Yu, Dianhe, Yao, Dianyi, Yin, Xianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785064/
https://www.ncbi.nlm.nih.gov/pubmed/36558443
http://dx.doi.org/10.3390/nu14245284
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author Ren, Yunqing
Liu, Jipeng
Li, Wei
Zheng, Huiwen
Dai, Huatuo
Qiu, Guiying
Yu, Dianhe
Yao, Dianyi
Yin, Xianyong
author_facet Ren, Yunqing
Liu, Jipeng
Li, Wei
Zheng, Huiwen
Dai, Huatuo
Qiu, Guiying
Yu, Dianhe
Yao, Dianyi
Yin, Xianyong
author_sort Ren, Yunqing
collection PubMed
description Background: Vitamin D level has been reported to be associated with psoriasis, atopic dermatitis, and vitiligo. However, its causal relationship with the risk of these three diseases remains unclear. Methods: We obtained genome-wide association statistics for three measures of circulating vitamin D levels (25(OH)D in 120,618 individuals, and 25(OH)D3 and epimeric form C3-epi-25(OH)D3 in 40,562 individuals) and for the diseases psoriasis (3871 cases and 333,288 controls), atopic dermatitis (21,399 cases and 95,464 controls), and vitiligo (4680 cases and 39,586 controls). We performed Mendelian randomization using inverse-variance weighted, weighted median, MR-Egger, and MR-pleiotropy residual sum and outlier methods. We carried out sensitivity analyses to evaluate the robustness of the results. Results: We showed that elevated vitamin D levels protected individuals from developing psoriasis (OR = 0.995, p = 8.84 × 10(−4) for 25(OH)D; OR = 0.997, p = 1.81 × 10(−3) for 25(OH)D(3); and OR = 0.998, p = 0.044 for C3-epi-25(OH)D(3)). Genetically predicted risk of atopic dermatitis increased the levels of 25(OH)D (OR = 1.040, p = 7.14 × 10(−4)) and 25(OH)D(3) (OR = 1.208, p = 0.048). A sensitivity analysis suggested the robustness of these causal associations. Conclusions: This study reported causal relationships between circulating vitamin D levels and the risk of psoriasis, atopic dermatitis, and vitiligo. These findings provide potential disease intervention and monitoring targets.
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spelling pubmed-97850642022-12-24 Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis Ren, Yunqing Liu, Jipeng Li, Wei Zheng, Huiwen Dai, Huatuo Qiu, Guiying Yu, Dianhe Yao, Dianyi Yin, Xianyong Nutrients Article Background: Vitamin D level has been reported to be associated with psoriasis, atopic dermatitis, and vitiligo. However, its causal relationship with the risk of these three diseases remains unclear. Methods: We obtained genome-wide association statistics for three measures of circulating vitamin D levels (25(OH)D in 120,618 individuals, and 25(OH)D3 and epimeric form C3-epi-25(OH)D3 in 40,562 individuals) and for the diseases psoriasis (3871 cases and 333,288 controls), atopic dermatitis (21,399 cases and 95,464 controls), and vitiligo (4680 cases and 39,586 controls). We performed Mendelian randomization using inverse-variance weighted, weighted median, MR-Egger, and MR-pleiotropy residual sum and outlier methods. We carried out sensitivity analyses to evaluate the robustness of the results. Results: We showed that elevated vitamin D levels protected individuals from developing psoriasis (OR = 0.995, p = 8.84 × 10(−4) for 25(OH)D; OR = 0.997, p = 1.81 × 10(−3) for 25(OH)D(3); and OR = 0.998, p = 0.044 for C3-epi-25(OH)D(3)). Genetically predicted risk of atopic dermatitis increased the levels of 25(OH)D (OR = 1.040, p = 7.14 × 10(−4)) and 25(OH)D(3) (OR = 1.208, p = 0.048). A sensitivity analysis suggested the robustness of these causal associations. Conclusions: This study reported causal relationships between circulating vitamin D levels and the risk of psoriasis, atopic dermatitis, and vitiligo. These findings provide potential disease intervention and monitoring targets. MDPI 2022-12-11 /pmc/articles/PMC9785064/ /pubmed/36558443 http://dx.doi.org/10.3390/nu14245284 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ren, Yunqing
Liu, Jipeng
Li, Wei
Zheng, Huiwen
Dai, Huatuo
Qiu, Guiying
Yu, Dianhe
Yao, Dianyi
Yin, Xianyong
Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis
title Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis
title_full Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis
title_fullStr Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis
title_full_unstemmed Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis
title_short Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis
title_sort causal associations between vitamin d levels and psoriasis, atopic dermatitis, and vitiligo: a bidirectional two-sample mendelian randomization analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785064/
https://www.ncbi.nlm.nih.gov/pubmed/36558443
http://dx.doi.org/10.3390/nu14245284
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