Cargando…

Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches

Mitochondria are implicated in a wide range of functions apart from ATP generation, and, therefore, constitute one of the most important organelles of cell. Since healthy mitochondria are essential for proper cellular functioning and survival, mitochondrial dysfunction may lead to various pathologie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Tanzeel, Waseem, Rashid, Zehra, Zainy, Aiman, Ayesha, Bhardwaj, Priyanka, Ansari, Jaoud, Hassan, Md. Imtaiyaz, Islam, Asimul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785072/ https://www.ncbi.nlm.nih.gov/pubmed/36559149 http://dx.doi.org/10.3390/pharmaceutics14122657

Ejemplares similares

Unraveling the Binding Mechanism of Alzheimer’s Drugs with Irisin: Spectroscopic, Calorimetric, and Computational Approaches
por: Waseem, Rashid, et al.
Publicado: (2022)

FNDC5/Irisin: Physiology and Pathophysiology
por: Waseem, Rashid, et al.
Publicado: (2022)

Identification of Thermostable Xylose Reductase from Thermothelomyces thermophilus: A Biochemical Characterization Approach to Meet Biofuel Challenges
por: Ali, Nabeel, et al.
Publicado: (2022)

Testing the Ability of Non-Methylamine Osmolytes Present in Kidney Cells to Counteract the Deleterious Effects of Urea on Structure, Stability and Function of Proteins
por: Khan, Sheeza, et al.
Publicado: (2013)

Multispectroscopic and Molecular Docking Insight into Elucidating the Interaction of Irisin with Rivastigmine Tartrate: A Combinational Therapy Approach to Fight Alzheimer’s Disease
por: Waseem, Rashid, et al.
Publicado: (2021)

MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease
por: Waseem, Rashid, et al.
Publicado: (2021)

Cooperative Unfolding of Residual Structure in Heat Denatured Proteins by Urea and Guanidinium Chloride
por: Singh, Ritu, et al.
Publicado: (2015)

Cloning, expression, purification and characterization of human mitochondrial carbonic anhydrase VA
por: Idrees, Danish, et al.
Publicado: (2016)

Modulatory Role of Quercetin in Mitochondrial Dysfunction in Titanium Dioxide Nanoparticle-Induced Hepatotoxicity
por: Waseem, Mohd, et al.
Publicado: (2022)

Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches
por: Ali, Nabeel, et al.
Publicado: (2022)

Corona virus versus existence of human on the earth: A computational and biophysical approach
por: Zehra, Zainy, et al.
Publicado: (2020)

Carbohydrate-Based Macromolecular Crowding-Induced Stabilization of Proteins: Towards Understanding the Significance of the Size of the Crowder
por: Shahid, Sumra, et al.
Publicado: (2019)

Data on the role of accessible surface area on osmolytes-induced protein stabilization
por: Rahman, Safikur, et al.
Publicado: (2016)

Effects of Ethylene Glycol on the Structure and Stability of Myoglobin Using Spectroscopic, Interaction, and In Silico Approaches: Monomer Is Different from Those of Its Polymers
por: Parray, Zahoor Ahmad, et al.
Publicado: (2020)

Structure-based functional annotation of hypothetical proteins from Candida dubliniensis: a quest for potential drug targets
por: Kumar, Kundan, et al.
Publicado: (2014)

Purification and characterization of RGA2, a Rho2 GTPase-activating protein from Tinospora cordifolia
por: Amir, Mohd., et al.
Publicado: (2016)

Biophysical Elucidation of Fibrillation Inhibition by Sugar Osmolytes in α-Lactalbumin: Multispectroscopic and Molecular Docking Approaches
por: Bashir, Sania, et al.
Publicado: (2020)

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy
por: Gupta, Preeti, et al.
Publicado: (2021)

Biophysical Insights into Implications of PEG-400 on the α-Crystallin Structure: Multispectroscopic and Microscopic Approach
por: Shamsi, Anas, et al.
Publicado: (2020)

Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches
por: Parray, Zahoor Ahmad, et al.
Publicado: (2021)

Heterogeneity of Equilibrium Molten Globule State of Cytochrome c Induced by Weak Salt Denaturants under Physiological Condition
por: Rahaman, Hamidur, et al.
Publicado: (2015)

Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
por: Azhar, Md. Khabeer, et al.
Publicado: (2023)

Laccase Engineering: Redox Potential Is Not the Only Activity-Determining Feature in the Metalloproteins
por: Ali, Misha, et al.
Publicado: (2023)

Sequence Analysis of Hypothetical Proteins from Helicobacter pylori 26695 to Identify Potential Virulence Factors
por: Naqvi, Ahmad Abu Turab, et al.
Publicado: (2016)

Heparin Accelerates the Protein Aggregation via the Downhill Polymerization Mechanism: Multi-Spectroscopic Studies to Delineate the Implications on Proteinopathies
por: Ahanger, Ishfaq Ahmad, et al.
Publicado: (2021)

Delineating the Aggregation-Prone Hotspot Regions (Peptides) in the Human Cu/Zn Superoxide Dismutase 1
por: Wahiduzzaman,, et al.
Publicado: (2021)

Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies
por: Mohammad, Taj, et al.
Publicado: (2020)

Stability of uniformly labeled ((13)C and (15)N) cytochrome c and its L94G mutant
por: Naiyer, Abdullah, et al.
Publicado: (2021)

Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy
por: Shamsi, Anas, et al.
Publicado: (2020)

Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations
por: Kumar, Vijay, et al.
Publicado: (2017)

Structural Refolding and Thermal Stability of Myoglobin in the Presence of Mixture of Crowders: Importance of Various Interactions for Protein Stabilization in Crowded Conditions
por: Parray, Zahoor Ahmad, et al.
Publicado: (2021)

Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
por: Alam, Manzar, et al.
Publicado: (2021)

Measuring Structural Changes in Cytochrome c under Crowded Conditions Using In Vitro and In Silico Approaches
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria
por: Chistiakov, Dimitry A., et al.
Publicado: (2014)

Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1
por: Choudhury, Arunabh, et al.
Publicado: (2021)

Removing dysfunctional mitochondria from axons independent of mitophagy under pathophysiological conditions
por: Lin, Mei-Yao, et al.
Publicado: (2017)

Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases
por: Haun, Florian, et al.
Publicado: (2013)

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations
por: Amir, Mohd., et al.
Publicado: (2020)

Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach
por: Shafie, Alaa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u527kblbt5n09svkr4v20060qn