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Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder

OBJECTIVE: Patients with rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson’s disease (PD-RBD) tend to have poor cognitive performance and faster cognitive deterioration, and the potential mechanism is still ambiguous. Therefore, this study aimed to detect the alterations in local b...

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Autores principales: Jiang, Xu, Pan, Yang, Zhu, Sha, Wang, Yaxi, Gu, Ruxin, Jiang, Yinyin, Shen, Bo, Zhu, Jun, Xu, Shulan, Yan, Jun, Dong, Jingde, Zhang, Wenbin, Xiao, Chaoyong, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785149/
https://www.ncbi.nlm.nih.gov/pubmed/36570022
http://dx.doi.org/10.2147/NDT.S384752
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author Jiang, Xu
Pan, Yang
Zhu, Sha
Wang, Yaxi
Gu, Ruxin
Jiang, Yinyin
Shen, Bo
Zhu, Jun
Xu, Shulan
Yan, Jun
Dong, Jingde
Zhang, Wenbin
Xiao, Chaoyong
Zhang, Li
author_facet Jiang, Xu
Pan, Yang
Zhu, Sha
Wang, Yaxi
Gu, Ruxin
Jiang, Yinyin
Shen, Bo
Zhu, Jun
Xu, Shulan
Yan, Jun
Dong, Jingde
Zhang, Wenbin
Xiao, Chaoyong
Zhang, Li
author_sort Jiang, Xu
collection PubMed
description OBJECTIVE: Patients with rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson’s disease (PD-RBD) tend to have poor cognitive performance and faster cognitive deterioration, and the potential mechanism is still ambiguous. Therefore, this study aimed to detect the alterations in local brain function in PD-RBD. METHODS: Fifty patients, including 23 patients with PD-RBD and 27 patients with PD without RBD (PD-nRBD), and 26 healthy controls were enrolled. All subjects were subjected to one-night polysomnography and underwent resting-state functional magnetic resonance imaging (rs-fMRI). The fMRI images of the three groups were analyzed by regional homogeneity (ReHo) to observe the local neural activity. Correlations between altered ReHo values and chin electromyographic (EMG) density scores and cognitive scores in the PD subgroups were assessed. RESULTS: Compared with the patients with PD-nRBD, the patients with PD-RBD had higher ReHo values in the frontal cortex (the right superior frontal gyrus, the right middle frontal gyrus and the left medial superior frontal gyrus), the right caudate nucleus and the right anterior cingulate gyrus, and compared with the HCs, the patients with PD-RBD had lower ReHo values in the bilateral cuneus, the bilateral precuneus, the left inferior temporal gyrus and the left inferior occipital gyrus. For the patients with PD-RBD, the phasic chin EMG density scores were positively correlated with the ReHo values in the left medial superior frontal gyrus, and the tonic chin EMG density scores were positively correlated with the ReHo values in the right anterior cingulate gyrus. CONCLUSION: This study indicates that increased ReHo in the frontal cortex, the caudate nucleus and the anterior cingulate gyrus may be linked with the abnormal motor behaviors during REM sleep and that decreased ReHo in the posterior regions may be related to the visuospatial–executive function in patients with PD-RBD.
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spelling pubmed-97851492022-12-24 Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder Jiang, Xu Pan, Yang Zhu, Sha Wang, Yaxi Gu, Ruxin Jiang, Yinyin Shen, Bo Zhu, Jun Xu, Shulan Yan, Jun Dong, Jingde Zhang, Wenbin Xiao, Chaoyong Zhang, Li Neuropsychiatr Dis Treat Original Research OBJECTIVE: Patients with rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson’s disease (PD-RBD) tend to have poor cognitive performance and faster cognitive deterioration, and the potential mechanism is still ambiguous. Therefore, this study aimed to detect the alterations in local brain function in PD-RBD. METHODS: Fifty patients, including 23 patients with PD-RBD and 27 patients with PD without RBD (PD-nRBD), and 26 healthy controls were enrolled. All subjects were subjected to one-night polysomnography and underwent resting-state functional magnetic resonance imaging (rs-fMRI). The fMRI images of the three groups were analyzed by regional homogeneity (ReHo) to observe the local neural activity. Correlations between altered ReHo values and chin electromyographic (EMG) density scores and cognitive scores in the PD subgroups were assessed. RESULTS: Compared with the patients with PD-nRBD, the patients with PD-RBD had higher ReHo values in the frontal cortex (the right superior frontal gyrus, the right middle frontal gyrus and the left medial superior frontal gyrus), the right caudate nucleus and the right anterior cingulate gyrus, and compared with the HCs, the patients with PD-RBD had lower ReHo values in the bilateral cuneus, the bilateral precuneus, the left inferior temporal gyrus and the left inferior occipital gyrus. For the patients with PD-RBD, the phasic chin EMG density scores were positively correlated with the ReHo values in the left medial superior frontal gyrus, and the tonic chin EMG density scores were positively correlated with the ReHo values in the right anterior cingulate gyrus. CONCLUSION: This study indicates that increased ReHo in the frontal cortex, the caudate nucleus and the anterior cingulate gyrus may be linked with the abnormal motor behaviors during REM sleep and that decreased ReHo in the posterior regions may be related to the visuospatial–executive function in patients with PD-RBD. Dove 2022-12-19 /pmc/articles/PMC9785149/ /pubmed/36570022 http://dx.doi.org/10.2147/NDT.S384752 Text en © 2022 Jiang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Jiang, Xu
Pan, Yang
Zhu, Sha
Wang, Yaxi
Gu, Ruxin
Jiang, Yinyin
Shen, Bo
Zhu, Jun
Xu, Shulan
Yan, Jun
Dong, Jingde
Zhang, Wenbin
Xiao, Chaoyong
Zhang, Li
Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
title Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
title_full Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
title_fullStr Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
title_full_unstemmed Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
title_short Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
title_sort alterations of regional homogeneity in parkinson’s disease with rapid eye movement sleep behavior disorder
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785149/
https://www.ncbi.nlm.nih.gov/pubmed/36570022
http://dx.doi.org/10.2147/NDT.S384752
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