Cargando…
Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity
Natural plant essential oils cannot be applied on a large scale due to their high volatility, easy deactivation, etc. This study provides a new method to prepare a long-lasting, slow-release essential oil product by taking advantage of solid lipid nanoparticles, which will provide a scientific guide...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785162/ https://www.ncbi.nlm.nih.gov/pubmed/36558312 http://dx.doi.org/10.3390/nano12244460 |
_version_ | 1784857981865689088 |
---|---|
author | Chen, Jiajia Li, Shangjian Zheng, Qinhua Feng, Xiaolin Tan, Weijian Feng, Kexin Liu, Yuntong Hu, Wenzhong |
author_facet | Chen, Jiajia Li, Shangjian Zheng, Qinhua Feng, Xiaolin Tan, Weijian Feng, Kexin Liu, Yuntong Hu, Wenzhong |
author_sort | Chen, Jiajia |
collection | PubMed |
description | Natural plant essential oils cannot be applied on a large scale due to their high volatility, easy deactivation, etc. This study provides a new method to prepare a long-lasting, slow-release essential oil product by taking advantage of solid lipid nanoparticles, which will provide a scientific guideline for the future essential oil industry. In this article, solid lipid cinnamaldehyde nanoparticles were prepared using an ultrahigh-pressure homogenization method. SLN-CA with a particle size of 74 ± 5 nm, PDI of 0.153 ± 0.032, and zeta potential of −44.36 ± 2.2 mV was screened using an additional amount of cinnamaldehyde, the ratio of oil phase components, and the homogenization pressure and number of times as factors. Differential thermal analysis and spectroscopy demonstrated that cinnamaldehyde was successfully encapsulated inside the nanoparticles. The change in particle size of nanoparticles under different conditions and times was used as an indicator of stability. The stability of the finished nanoparticles was evaluated. The retention and slow-release ability of cinnamaldehyde were investigated using the concentration of cinnamaldehyde in nanoparticles as an indicator. The results showed that after 15 days, SLN-CA retained 52.36% of the concentration from 15 days prior. The bacterial inhibition test shows that SLN-CA can inhibit bacteria |
format | Online Article Text |
id | pubmed-9785162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97851622022-12-24 Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity Chen, Jiajia Li, Shangjian Zheng, Qinhua Feng, Xiaolin Tan, Weijian Feng, Kexin Liu, Yuntong Hu, Wenzhong Nanomaterials (Basel) Article Natural plant essential oils cannot be applied on a large scale due to their high volatility, easy deactivation, etc. This study provides a new method to prepare a long-lasting, slow-release essential oil product by taking advantage of solid lipid nanoparticles, which will provide a scientific guideline for the future essential oil industry. In this article, solid lipid cinnamaldehyde nanoparticles were prepared using an ultrahigh-pressure homogenization method. SLN-CA with a particle size of 74 ± 5 nm, PDI of 0.153 ± 0.032, and zeta potential of −44.36 ± 2.2 mV was screened using an additional amount of cinnamaldehyde, the ratio of oil phase components, and the homogenization pressure and number of times as factors. Differential thermal analysis and spectroscopy demonstrated that cinnamaldehyde was successfully encapsulated inside the nanoparticles. The change in particle size of nanoparticles under different conditions and times was used as an indicator of stability. The stability of the finished nanoparticles was evaluated. The retention and slow-release ability of cinnamaldehyde were investigated using the concentration of cinnamaldehyde in nanoparticles as an indicator. The results showed that after 15 days, SLN-CA retained 52.36% of the concentration from 15 days prior. The bacterial inhibition test shows that SLN-CA can inhibit bacteria MDPI 2022-12-15 /pmc/articles/PMC9785162/ /pubmed/36558312 http://dx.doi.org/10.3390/nano12244460 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Jiajia Li, Shangjian Zheng, Qinhua Feng, Xiaolin Tan, Weijian Feng, Kexin Liu, Yuntong Hu, Wenzhong Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity |
title | Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity |
title_full | Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity |
title_fullStr | Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity |
title_full_unstemmed | Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity |
title_short | Preparation of Solid Lipid Nanoparticles of Cinnamaldehyde and Determination of Sustained Release Capacity |
title_sort | preparation of solid lipid nanoparticles of cinnamaldehyde and determination of sustained release capacity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785162/ https://www.ncbi.nlm.nih.gov/pubmed/36558312 http://dx.doi.org/10.3390/nano12244460 |
work_keys_str_mv | AT chenjiajia preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity AT lishangjian preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity AT zhengqinhua preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity AT fengxiaolin preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity AT tanweijian preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity AT fengkexin preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity AT liuyuntong preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity AT huwenzhong preparationofsolidlipidnanoparticlesofcinnamaldehydeanddeterminationofsustainedreleasecapacity |