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Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting

Background: Arterial stiffness, measured by pulse wave velocity (PWV), is a purported mechanism linking sedentary behavior to cardiovascular disease. This secondary analysis compared associations between measured carotid–femoral PWV (cfPWV) and carotid–radial (crPWV) responses to an acute bout of pr...

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Autores principales: Alansare, Abdullah Bandar, Stoner, Lee, Aljuhani, Osama Eid, Gibbs, Bethany Barone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785284/
https://www.ncbi.nlm.nih.gov/pubmed/36547408
http://dx.doi.org/10.3390/jcdd9120411
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author Alansare, Abdullah Bandar
Stoner, Lee
Aljuhani, Osama Eid
Gibbs, Bethany Barone
author_facet Alansare, Abdullah Bandar
Stoner, Lee
Aljuhani, Osama Eid
Gibbs, Bethany Barone
author_sort Alansare, Abdullah Bandar
collection PubMed
description Background: Arterial stiffness, measured by pulse wave velocity (PWV), is a purported mechanism linking sedentary behavior to cardiovascular disease. This secondary analysis compared associations between measured carotid–femoral PWV (cfPWV) and carotid–radial (crPWV) responses to an acute bout of prolonged sitting with mathematically estimated cfPWV (ePWV). Methods: Overweight/obese adults with elevated blood pressure were enrolled (n = 25; 42 ± 12 yrs; 64% males). Participants performed an 8 h simulated workday of mostly sitting. cfPWV and crPWV were measured while supine in the morning, midday, and afternoon. ePWV was calculated at the same timepoints using age and seated mean arterial pressure (MAP). Pearson correlation coefficients associated ePWV with cfPWV and crPWV. Generalized linear models separately examined the effects of time on cfPWV, crPWV, and ePWV. Results: ePWV significantly associated with cfPWV and crPWV (r = 0.69 and 0.55, respectively; p < 0.05) in the morning (baseline). cfPWV significantly increased over time (β = 0.52 ± 0.20 and 0.48 ± 0.21 with and without MAP adjustment, respectively; p < 0.05). In contrast, ePWV and crPWV did not significantly increase overtime (β = 0.14 ± 0.09 and 0.25 ± 0.23, respectively; p > 0.05). Conclusions: Our results suggest that, although ePWV is associated with cfPWV and crPWV at a fixed timepoint, ePWV responds differently to prolonged sitting and likely does not capture the same acute vascular responses.
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spelling pubmed-97852842022-12-24 Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting Alansare, Abdullah Bandar Stoner, Lee Aljuhani, Osama Eid Gibbs, Bethany Barone J Cardiovasc Dev Dis Article Background: Arterial stiffness, measured by pulse wave velocity (PWV), is a purported mechanism linking sedentary behavior to cardiovascular disease. This secondary analysis compared associations between measured carotid–femoral PWV (cfPWV) and carotid–radial (crPWV) responses to an acute bout of prolonged sitting with mathematically estimated cfPWV (ePWV). Methods: Overweight/obese adults with elevated blood pressure were enrolled (n = 25; 42 ± 12 yrs; 64% males). Participants performed an 8 h simulated workday of mostly sitting. cfPWV and crPWV were measured while supine in the morning, midday, and afternoon. ePWV was calculated at the same timepoints using age and seated mean arterial pressure (MAP). Pearson correlation coefficients associated ePWV with cfPWV and crPWV. Generalized linear models separately examined the effects of time on cfPWV, crPWV, and ePWV. Results: ePWV significantly associated with cfPWV and crPWV (r = 0.69 and 0.55, respectively; p < 0.05) in the morning (baseline). cfPWV significantly increased over time (β = 0.52 ± 0.20 and 0.48 ± 0.21 with and without MAP adjustment, respectively; p < 0.05). In contrast, ePWV and crPWV did not significantly increase overtime (β = 0.14 ± 0.09 and 0.25 ± 0.23, respectively; p > 0.05). Conclusions: Our results suggest that, although ePWV is associated with cfPWV and crPWV at a fixed timepoint, ePWV responds differently to prolonged sitting and likely does not capture the same acute vascular responses. MDPI 2022-11-23 /pmc/articles/PMC9785284/ /pubmed/36547408 http://dx.doi.org/10.3390/jcdd9120411 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alansare, Abdullah Bandar
Stoner, Lee
Aljuhani, Osama Eid
Gibbs, Bethany Barone
Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting
title Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting
title_full Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting
title_fullStr Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting
title_full_unstemmed Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting
title_short Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting
title_sort utility of estimated pulse wave velocity for tracking the arterial response to prolonged sitting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785284/
https://www.ncbi.nlm.nih.gov/pubmed/36547408
http://dx.doi.org/10.3390/jcdd9120411
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