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Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
Objective: To investigate the clinical characteristics of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) and its related factors. Methods: Ninety-one hospitalized SLE patients and thirty healthy controls were enrolled. All subjects completed pure tone audiometry (PTA), extende...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785353/ https://www.ncbi.nlm.nih.gov/pubmed/36556147 http://dx.doi.org/10.3390/jcm11247527 |
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author | Chen, Huixian Wang, Fan Yang, Ye Hua, Bingzhu Wang, Hong Chen, Jie Feng, Xuebing |
author_facet | Chen, Huixian Wang, Fan Yang, Ye Hua, Bingzhu Wang, Hong Chen, Jie Feng, Xuebing |
author_sort | Chen, Huixian |
collection | PubMed |
description | Objective: To investigate the clinical characteristics of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) and its related factors. Methods: Ninety-one hospitalized SLE patients and thirty healthy controls were enrolled. All subjects completed pure tone audiometry (PTA), extended high frequency audiometry (EHFA) and distortion product otoacoustic emission (DPOAE) to assess hearing function. SLE patients were divided into two groups according to the presence or absence of HL, and the risk factors of HL were determined by multivariate logistic regression. Results: The incidence of HL was 27.47% in SLE patients, significantly higher than in the control group (3.3%) and most cases were mild-to-moderate, bilateral and predominantly sensorineural. Compared with the control group, the hearing thresholds of SLE patients increased significantly in the middle and high frequencies starting from 2000 Hz. Even though the PTA test results were normal, the EHFA test results showed significant differences in hearing impairment between SLE patients and normal controls. For patients with abnormal PTA results, the signal-to-noise ratio (SNR) in DPOAE was markedly reduced, and the pass rate was also decreased. The Systemic Lupus International Collaborating Clinics Damage Index (SDI, OR 9.13) and secondary Sjögren’s syndrome (sSS, OR 8.20) were identified as independent associated factors for HL, and there was no difference in PTA and EHFA at all frequencies between hydroxychloroquine users and non-users. Conclusions: HL is not rare in SLE patients, and EHFA can help identify early hearing impairment. Having a high SDI score and secondary Sjögren’s syndrome may predict the presence of HL in SLE. |
format | Online Article Text |
id | pubmed-9785353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97853532022-12-24 Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus Chen, Huixian Wang, Fan Yang, Ye Hua, Bingzhu Wang, Hong Chen, Jie Feng, Xuebing J Clin Med Article Objective: To investigate the clinical characteristics of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) and its related factors. Methods: Ninety-one hospitalized SLE patients and thirty healthy controls were enrolled. All subjects completed pure tone audiometry (PTA), extended high frequency audiometry (EHFA) and distortion product otoacoustic emission (DPOAE) to assess hearing function. SLE patients were divided into two groups according to the presence or absence of HL, and the risk factors of HL were determined by multivariate logistic regression. Results: The incidence of HL was 27.47% in SLE patients, significantly higher than in the control group (3.3%) and most cases were mild-to-moderate, bilateral and predominantly sensorineural. Compared with the control group, the hearing thresholds of SLE patients increased significantly in the middle and high frequencies starting from 2000 Hz. Even though the PTA test results were normal, the EHFA test results showed significant differences in hearing impairment between SLE patients and normal controls. For patients with abnormal PTA results, the signal-to-noise ratio (SNR) in DPOAE was markedly reduced, and the pass rate was also decreased. The Systemic Lupus International Collaborating Clinics Damage Index (SDI, OR 9.13) and secondary Sjögren’s syndrome (sSS, OR 8.20) were identified as independent associated factors for HL, and there was no difference in PTA and EHFA at all frequencies between hydroxychloroquine users and non-users. Conclusions: HL is not rare in SLE patients, and EHFA can help identify early hearing impairment. Having a high SDI score and secondary Sjögren’s syndrome may predict the presence of HL in SLE. MDPI 2022-12-19 /pmc/articles/PMC9785353/ /pubmed/36556147 http://dx.doi.org/10.3390/jcm11247527 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Huixian Wang, Fan Yang, Ye Hua, Bingzhu Wang, Hong Chen, Jie Feng, Xuebing Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus |
title | Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus |
title_full | Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus |
title_fullStr | Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus |
title_full_unstemmed | Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus |
title_short | Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus |
title_sort | characteristics of hearing loss in patients with systemic lupus erythematosus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785353/ https://www.ncbi.nlm.nih.gov/pubmed/36556147 http://dx.doi.org/10.3390/jcm11247527 |
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