Cargando…

Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus

Objective: To investigate the clinical characteristics of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) and its related factors. Methods: Ninety-one hospitalized SLE patients and thirty healthy controls were enrolled. All subjects completed pure tone audiometry (PTA), extende...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Huixian, Wang, Fan, Yang, Ye, Hua, Bingzhu, Wang, Hong, Chen, Jie, Feng, Xuebing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785353/
https://www.ncbi.nlm.nih.gov/pubmed/36556147
http://dx.doi.org/10.3390/jcm11247527
_version_ 1784858027874058240
author Chen, Huixian
Wang, Fan
Yang, Ye
Hua, Bingzhu
Wang, Hong
Chen, Jie
Feng, Xuebing
author_facet Chen, Huixian
Wang, Fan
Yang, Ye
Hua, Bingzhu
Wang, Hong
Chen, Jie
Feng, Xuebing
author_sort Chen, Huixian
collection PubMed
description Objective: To investigate the clinical characteristics of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) and its related factors. Methods: Ninety-one hospitalized SLE patients and thirty healthy controls were enrolled. All subjects completed pure tone audiometry (PTA), extended high frequency audiometry (EHFA) and distortion product otoacoustic emission (DPOAE) to assess hearing function. SLE patients were divided into two groups according to the presence or absence of HL, and the risk factors of HL were determined by multivariate logistic regression. Results: The incidence of HL was 27.47% in SLE patients, significantly higher than in the control group (3.3%) and most cases were mild-to-moderate, bilateral and predominantly sensorineural. Compared with the control group, the hearing thresholds of SLE patients increased significantly in the middle and high frequencies starting from 2000 Hz. Even though the PTA test results were normal, the EHFA test results showed significant differences in hearing impairment between SLE patients and normal controls. For patients with abnormal PTA results, the signal-to-noise ratio (SNR) in DPOAE was markedly reduced, and the pass rate was also decreased. The Systemic Lupus International Collaborating Clinics Damage Index (SDI, OR 9.13) and secondary Sjögren’s syndrome (sSS, OR 8.20) were identified as independent associated factors for HL, and there was no difference in PTA and EHFA at all frequencies between hydroxychloroquine users and non-users. Conclusions: HL is not rare in SLE patients, and EHFA can help identify early hearing impairment. Having a high SDI score and secondary Sjögren’s syndrome may predict the presence of HL in SLE.
format Online
Article
Text
id pubmed-9785353
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97853532022-12-24 Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus Chen, Huixian Wang, Fan Yang, Ye Hua, Bingzhu Wang, Hong Chen, Jie Feng, Xuebing J Clin Med Article Objective: To investigate the clinical characteristics of hearing loss (HL) in patients with systemic lupus erythematosus (SLE) and its related factors. Methods: Ninety-one hospitalized SLE patients and thirty healthy controls were enrolled. All subjects completed pure tone audiometry (PTA), extended high frequency audiometry (EHFA) and distortion product otoacoustic emission (DPOAE) to assess hearing function. SLE patients were divided into two groups according to the presence or absence of HL, and the risk factors of HL were determined by multivariate logistic regression. Results: The incidence of HL was 27.47% in SLE patients, significantly higher than in the control group (3.3%) and most cases were mild-to-moderate, bilateral and predominantly sensorineural. Compared with the control group, the hearing thresholds of SLE patients increased significantly in the middle and high frequencies starting from 2000 Hz. Even though the PTA test results were normal, the EHFA test results showed significant differences in hearing impairment between SLE patients and normal controls. For patients with abnormal PTA results, the signal-to-noise ratio (SNR) in DPOAE was markedly reduced, and the pass rate was also decreased. The Systemic Lupus International Collaborating Clinics Damage Index (SDI, OR 9.13) and secondary Sjögren’s syndrome (sSS, OR 8.20) were identified as independent associated factors for HL, and there was no difference in PTA and EHFA at all frequencies between hydroxychloroquine users and non-users. Conclusions: HL is not rare in SLE patients, and EHFA can help identify early hearing impairment. Having a high SDI score and secondary Sjögren’s syndrome may predict the presence of HL in SLE. MDPI 2022-12-19 /pmc/articles/PMC9785353/ /pubmed/36556147 http://dx.doi.org/10.3390/jcm11247527 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Huixian
Wang, Fan
Yang, Ye
Hua, Bingzhu
Wang, Hong
Chen, Jie
Feng, Xuebing
Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
title Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
title_full Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
title_fullStr Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
title_full_unstemmed Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
title_short Characteristics of Hearing Loss in Patients with Systemic Lupus Erythematosus
title_sort characteristics of hearing loss in patients with systemic lupus erythematosus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785353/
https://www.ncbi.nlm.nih.gov/pubmed/36556147
http://dx.doi.org/10.3390/jcm11247527
work_keys_str_mv AT chenhuixian characteristicsofhearinglossinpatientswithsystemiclupuserythematosus
AT wangfan characteristicsofhearinglossinpatientswithsystemiclupuserythematosus
AT yangye characteristicsofhearinglossinpatientswithsystemiclupuserythematosus
AT huabingzhu characteristicsofhearinglossinpatientswithsystemiclupuserythematosus
AT wanghong characteristicsofhearinglossinpatientswithsystemiclupuserythematosus
AT chenjie characteristicsofhearinglossinpatientswithsystemiclupuserythematosus
AT fengxuebing characteristicsofhearinglossinpatientswithsystemiclupuserythematosus