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Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study

Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization da...

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Autores principales: Martínez-Solano, Jorge, Gutiérrez-Ibañes, Enrique, Ortiz-Bautista, Carlos, García-Cosío, María Dolores, Sarnago-Cebada, Fernando, Díaz-Molina, Beatriz, Pascual, Isaac, Oteo-Domínguez, Juan Francisco, Gómez-Bueno, Manuel, Calviño-Santos, Ramón, Crespo-Leiro, María G., Gómez-Hospital, Joan Antoni, Díez-López, Carles, García-Lara, Juan, Garrido-Bravo, Iris P., de la Fuente-Galán, Luis, López-Díaz, Javier, Mirabet-Pérez, Sonia, Martínez-Sellés, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785366/
https://www.ncbi.nlm.nih.gov/pubmed/36547436
http://dx.doi.org/10.3390/jcdd9120439
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author Martínez-Solano, Jorge
Gutiérrez-Ibañes, Enrique
Ortiz-Bautista, Carlos
García-Cosío, María Dolores
Sarnago-Cebada, Fernando
Díaz-Molina, Beatriz
Pascual, Isaac
Oteo-Domínguez, Juan Francisco
Gómez-Bueno, Manuel
Calviño-Santos, Ramón
Crespo-Leiro, María G.
Gómez-Hospital, Joan Antoni
Díez-López, Carles
García-Lara, Juan
Garrido-Bravo, Iris P.
de la Fuente-Galán, Luis
López-Díaz, Javier
Mirabet-Pérez, Sonia
Martínez-Sellés, Manuel
author_facet Martínez-Solano, Jorge
Gutiérrez-Ibañes, Enrique
Ortiz-Bautista, Carlos
García-Cosío, María Dolores
Sarnago-Cebada, Fernando
Díaz-Molina, Beatriz
Pascual, Isaac
Oteo-Domínguez, Juan Francisco
Gómez-Bueno, Manuel
Calviño-Santos, Ramón
Crespo-Leiro, María G.
Gómez-Hospital, Joan Antoni
Díez-López, Carles
García-Lara, Juan
Garrido-Bravo, Iris P.
de la Fuente-Galán, Luis
López-Díaz, Javier
Mirabet-Pérez, Sonia
Martínez-Sellés, Manuel
author_sort Martínez-Solano, Jorge
collection PubMed
description Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3–50.0 vs. 47.0 mmHg, IQR 34.6–59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3–3.7 vs. 2.0 Wood units, IQR 1.4–3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 ± 0.5 mm vs. 0.2 ± 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients.
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spelling pubmed-97853662022-12-24 Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study Martínez-Solano, Jorge Gutiérrez-Ibañes, Enrique Ortiz-Bautista, Carlos García-Cosío, María Dolores Sarnago-Cebada, Fernando Díaz-Molina, Beatriz Pascual, Isaac Oteo-Domínguez, Juan Francisco Gómez-Bueno, Manuel Calviño-Santos, Ramón Crespo-Leiro, María G. Gómez-Hospital, Joan Antoni Díez-López, Carles García-Lara, Juan Garrido-Bravo, Iris P. de la Fuente-Galán, Luis López-Díaz, Javier Mirabet-Pérez, Sonia Martínez-Sellés, Manuel J Cardiovasc Dev Dis Article Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3–50.0 vs. 47.0 mmHg, IQR 34.6–59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3–3.7 vs. 2.0 Wood units, IQR 1.4–3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 ± 0.5 mm vs. 0.2 ± 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients. MDPI 2022-12-06 /pmc/articles/PMC9785366/ /pubmed/36547436 http://dx.doi.org/10.3390/jcdd9120439 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martínez-Solano, Jorge
Gutiérrez-Ibañes, Enrique
Ortiz-Bautista, Carlos
García-Cosío, María Dolores
Sarnago-Cebada, Fernando
Díaz-Molina, Beatriz
Pascual, Isaac
Oteo-Domínguez, Juan Francisco
Gómez-Bueno, Manuel
Calviño-Santos, Ramón
Crespo-Leiro, María G.
Gómez-Hospital, Joan Antoni
Díez-López, Carles
García-Lara, Juan
Garrido-Bravo, Iris P.
de la Fuente-Galán, Luis
López-Díaz, Javier
Mirabet-Pérez, Sonia
Martínez-Sellés, Manuel
Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_full Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_fullStr Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_full_unstemmed Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_short Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_sort pulmonary vascular remodeling and prognosis in patients evaluated for heart transplantation: insights from the octopus-chf study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785366/
https://www.ncbi.nlm.nih.gov/pubmed/36547436
http://dx.doi.org/10.3390/jcdd9120439
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