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Multiparametric MRI Features of Breast Cancer Molecular Subtypes

Background and Objectives: Breast cancer (BC) molecular subtypes have unique incidence, survival and response to therapy. There are five BC subtypes described by immunohistochemistry: luminal A, luminal B HER2 positive and HER2 negative, triple negative (TNBC) and HER2-enriched. Multiparametric brea...

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Autores principales: Szep, Madalina, Pintican, Roxana, Boca, Bianca, Perja, Andra, Duma, Magdalena, Feier, Diana, Fetica, Bogdan, Eniu, Dan, Dudea, Sorin Marian, Chiorean, Angelica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785392/
https://www.ncbi.nlm.nih.gov/pubmed/36556918
http://dx.doi.org/10.3390/medicina58121716
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author Szep, Madalina
Pintican, Roxana
Boca, Bianca
Perja, Andra
Duma, Magdalena
Feier, Diana
Fetica, Bogdan
Eniu, Dan
Dudea, Sorin Marian
Chiorean, Angelica
author_facet Szep, Madalina
Pintican, Roxana
Boca, Bianca
Perja, Andra
Duma, Magdalena
Feier, Diana
Fetica, Bogdan
Eniu, Dan
Dudea, Sorin Marian
Chiorean, Angelica
author_sort Szep, Madalina
collection PubMed
description Background and Objectives: Breast cancer (BC) molecular subtypes have unique incidence, survival and response to therapy. There are five BC subtypes described by immunohistochemistry: luminal A, luminal B HER2 positive and HER2 negative, triple negative (TNBC) and HER2-enriched. Multiparametric breast MRI (magnetic resonance imaging) provides morphological and functional characteristics of breast tumours and is nowadays recommended in the preoperative setting. Aim: To evaluate the multiparametric MRI features (T2-WI, ADC values and DCE) of breast tumours along with breast density and background parenchymal enhancement (BPE) features among different BC molecular subtypes. Materials and Methods: This was a retrospective study which included 344 patients. All underwent multiparametric breast MRI (T2WI, ADC and DCE sequences) and features were extracted according to the latest BIRADS lexicon. The inter-reader agreement was assessed using the intraclass coefficient (ICC) between the ROI of ADC obtained from the two breast imagers (experienced and moderately experienced). Results: The study population was divided as follows: 89 (26%) with luminal A, 39 (11.5%) luminal B HER2 positive, 168 (48.5%) luminal B HER2 negative, 41 (12%) triple negative (TNBC) and 7 (2%) with HER2 enriched. Luminal A tumours were associated with special histology type, smallest tumour size and persistent kinetic curve (all p-values < 0.05). Luminal B HER2 negative tumours were associated with lowest ADC value (0.77 × 10(−3) mm(2)/s(2)), which predicts the BC molecular subtype with an accuracy of 0.583. TNBC were associated with asymmetric and moderate/marked BPE, round/oval masses with circumscribed margins and rim enhancement (all p-values < 0.05). HER2 enriched BC were associated with the largest tumour size (mean 37.28 mm, p-value = 0.02). Conclusions: BC molecular subtypes can be associated with T2WI, ADC and DCE MRI features. ADC can help predict the luminal B HER2 negative cases.
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spelling pubmed-97853922022-12-24 Multiparametric MRI Features of Breast Cancer Molecular Subtypes Szep, Madalina Pintican, Roxana Boca, Bianca Perja, Andra Duma, Magdalena Feier, Diana Fetica, Bogdan Eniu, Dan Dudea, Sorin Marian Chiorean, Angelica Medicina (Kaunas) Article Background and Objectives: Breast cancer (BC) molecular subtypes have unique incidence, survival and response to therapy. There are five BC subtypes described by immunohistochemistry: luminal A, luminal B HER2 positive and HER2 negative, triple negative (TNBC) and HER2-enriched. Multiparametric breast MRI (magnetic resonance imaging) provides morphological and functional characteristics of breast tumours and is nowadays recommended in the preoperative setting. Aim: To evaluate the multiparametric MRI features (T2-WI, ADC values and DCE) of breast tumours along with breast density and background parenchymal enhancement (BPE) features among different BC molecular subtypes. Materials and Methods: This was a retrospective study which included 344 patients. All underwent multiparametric breast MRI (T2WI, ADC and DCE sequences) and features were extracted according to the latest BIRADS lexicon. The inter-reader agreement was assessed using the intraclass coefficient (ICC) between the ROI of ADC obtained from the two breast imagers (experienced and moderately experienced). Results: The study population was divided as follows: 89 (26%) with luminal A, 39 (11.5%) luminal B HER2 positive, 168 (48.5%) luminal B HER2 negative, 41 (12%) triple negative (TNBC) and 7 (2%) with HER2 enriched. Luminal A tumours were associated with special histology type, smallest tumour size and persistent kinetic curve (all p-values < 0.05). Luminal B HER2 negative tumours were associated with lowest ADC value (0.77 × 10(−3) mm(2)/s(2)), which predicts the BC molecular subtype with an accuracy of 0.583. TNBC were associated with asymmetric and moderate/marked BPE, round/oval masses with circumscribed margins and rim enhancement (all p-values < 0.05). HER2 enriched BC were associated with the largest tumour size (mean 37.28 mm, p-value = 0.02). Conclusions: BC molecular subtypes can be associated with T2WI, ADC and DCE MRI features. ADC can help predict the luminal B HER2 negative cases. MDPI 2022-11-23 /pmc/articles/PMC9785392/ /pubmed/36556918 http://dx.doi.org/10.3390/medicina58121716 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szep, Madalina
Pintican, Roxana
Boca, Bianca
Perja, Andra
Duma, Magdalena
Feier, Diana
Fetica, Bogdan
Eniu, Dan
Dudea, Sorin Marian
Chiorean, Angelica
Multiparametric MRI Features of Breast Cancer Molecular Subtypes
title Multiparametric MRI Features of Breast Cancer Molecular Subtypes
title_full Multiparametric MRI Features of Breast Cancer Molecular Subtypes
title_fullStr Multiparametric MRI Features of Breast Cancer Molecular Subtypes
title_full_unstemmed Multiparametric MRI Features of Breast Cancer Molecular Subtypes
title_short Multiparametric MRI Features of Breast Cancer Molecular Subtypes
title_sort multiparametric mri features of breast cancer molecular subtypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785392/
https://www.ncbi.nlm.nih.gov/pubmed/36556918
http://dx.doi.org/10.3390/medicina58121716
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