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Cardiac Rehabilitation for Older Women with Heart Failure
Background: the role that sex plays in impacting cardiac rehabilitation (CR) outcomes remains an important gap in knowledge. Methods: we assessed sex differences in clinical and functional outcomes in 2345 older patients with heart failure (HF) admitted to inpatient CR. Three outcomes were considere...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785443/ https://www.ncbi.nlm.nih.gov/pubmed/36556201 http://dx.doi.org/10.3390/jpm12121980 |
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author | Scrutinio, Domenico Guida, Pietro Dalla Vecchia, Laura Adelaide Corrà, Ugo Passantino, Andrea |
author_facet | Scrutinio, Domenico Guida, Pietro Dalla Vecchia, Laura Adelaide Corrà, Ugo Passantino, Andrea |
author_sort | Scrutinio, Domenico |
collection | PubMed |
description | Background: the role that sex plays in impacting cardiac rehabilitation (CR) outcomes remains an important gap in knowledge. Methods: we assessed sex differences in clinical and functional outcomes in 2345 older patients with heart failure (HF) admitted to inpatient CR. Three outcomes were considered: (1) the composite outcome of death during the index admission to CR or transfer to acute care; (2) three-year mortality; (3) change in six-minute walking distance (6MWD) from admission to discharge. Sex differences in outcomes were assessed using multivariable Cox or logistic regression models. Results: the hazard ratios of the composite outcome and of three-year mortality for females vs. males were 0.71 (95%CI:0.50–1.00; p = 0.049) and 0.68 (95%CI:0.59–0.79; p < 0.001), respectively. The standardized mean difference in 6MWD increase from admission to discharge between males and females was 0.10. The odds ratio of achieving an increase in 6MWD at discharge to values higher than the optimal sex-specific thresholds for predicting mortality for females vs. males was 2.21 (95%CI:1.53–3.20; p < 0.001). Conclusion: our findings suggest that older females with HF undergoing CR have better prognosis and garner similar improvement in 6MWD compared with their male counterparts. Nonetheless, females were more likely to achieve levels of functional capacity predictive of improved survival. |
format | Online Article Text |
id | pubmed-9785443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97854432022-12-24 Cardiac Rehabilitation for Older Women with Heart Failure Scrutinio, Domenico Guida, Pietro Dalla Vecchia, Laura Adelaide Corrà, Ugo Passantino, Andrea J Pers Med Article Background: the role that sex plays in impacting cardiac rehabilitation (CR) outcomes remains an important gap in knowledge. Methods: we assessed sex differences in clinical and functional outcomes in 2345 older patients with heart failure (HF) admitted to inpatient CR. Three outcomes were considered: (1) the composite outcome of death during the index admission to CR or transfer to acute care; (2) three-year mortality; (3) change in six-minute walking distance (6MWD) from admission to discharge. Sex differences in outcomes were assessed using multivariable Cox or logistic regression models. Results: the hazard ratios of the composite outcome and of three-year mortality for females vs. males were 0.71 (95%CI:0.50–1.00; p = 0.049) and 0.68 (95%CI:0.59–0.79; p < 0.001), respectively. The standardized mean difference in 6MWD increase from admission to discharge between males and females was 0.10. The odds ratio of achieving an increase in 6MWD at discharge to values higher than the optimal sex-specific thresholds for predicting mortality for females vs. males was 2.21 (95%CI:1.53–3.20; p < 0.001). Conclusion: our findings suggest that older females with HF undergoing CR have better prognosis and garner similar improvement in 6MWD compared with their male counterparts. Nonetheless, females were more likely to achieve levels of functional capacity predictive of improved survival. MDPI 2022-11-30 /pmc/articles/PMC9785443/ /pubmed/36556201 http://dx.doi.org/10.3390/jpm12121980 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Scrutinio, Domenico Guida, Pietro Dalla Vecchia, Laura Adelaide Corrà, Ugo Passantino, Andrea Cardiac Rehabilitation for Older Women with Heart Failure |
title | Cardiac Rehabilitation for Older Women with Heart Failure |
title_full | Cardiac Rehabilitation for Older Women with Heart Failure |
title_fullStr | Cardiac Rehabilitation for Older Women with Heart Failure |
title_full_unstemmed | Cardiac Rehabilitation for Older Women with Heart Failure |
title_short | Cardiac Rehabilitation for Older Women with Heart Failure |
title_sort | cardiac rehabilitation for older women with heart failure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785443/ https://www.ncbi.nlm.nih.gov/pubmed/36556201 http://dx.doi.org/10.3390/jpm12121980 |
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