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The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland
Background. Paediatric-onset MS (POMS) has a unique clinical profile compared to the more prevalent adult-onset MS. For this study, we aimed to determine the demographic and clinical characteristics of POMS in Poland as well as addressing some of its epidemiological aspects. Methods. A retrospective...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785459/ https://www.ncbi.nlm.nih.gov/pubmed/36556109 http://dx.doi.org/10.3390/jcm11247494 |
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author | Brola, Waldemar Steinborn, Barbara Żak, Marek Mazurkiewicz-Bełdzińska, Maria Jóźwiak, Sergiusz Sobolewski, Piotr Wilski, Maciej Bilska, Małgorzata Siedlarska, Magdalena Puzio-Bochen, Iwona Wencel-Warot, Agnieszka Lemka, Małgorzata Kroczka, Sławomir Czyżyk, Elżbieta Bocheńska, Małgorzata Emich-Widera, Ewa Pietruszewski, Jerzy Boćkowski, Leszek Kapica-Topczewska, Katarzyna Czarnowska, Agata Kułakowska, Alina Ujma-Czapska, Barbara Gruna-Ożarowska, Agata Przysło, Łukasz Połatyńska, Katarzyna Dudzińska, Magdalena Mitosek-Szewczyk, Krystyna Melnyk, Aleksandra Adamczyk-Sowa, Monika Kotulska, Katarzyna |
author_facet | Brola, Waldemar Steinborn, Barbara Żak, Marek Mazurkiewicz-Bełdzińska, Maria Jóźwiak, Sergiusz Sobolewski, Piotr Wilski, Maciej Bilska, Małgorzata Siedlarska, Magdalena Puzio-Bochen, Iwona Wencel-Warot, Agnieszka Lemka, Małgorzata Kroczka, Sławomir Czyżyk, Elżbieta Bocheńska, Małgorzata Emich-Widera, Ewa Pietruszewski, Jerzy Boćkowski, Leszek Kapica-Topczewska, Katarzyna Czarnowska, Agata Kułakowska, Alina Ujma-Czapska, Barbara Gruna-Ożarowska, Agata Przysło, Łukasz Połatyńska, Katarzyna Dudzińska, Magdalena Mitosek-Szewczyk, Krystyna Melnyk, Aleksandra Adamczyk-Sowa, Monika Kotulska, Katarzyna |
author_sort | Brola, Waldemar |
collection | PubMed |
description | Background. Paediatric-onset MS (POMS) has a unique clinical profile compared to the more prevalent adult-onset MS. For this study, we aimed to determine the demographic and clinical characteristics of POMS in Poland as well as addressing some of its epidemiological aspects. Methods. A retrospective study was conducted based on the Polish Multiple Sclerosis Registry, considering a population of children and adolescents with MS (age ≤ 18 years). Data were collected by all 13 centres across Poland specializing in diagnosing and treating POMS. The actual course of the disease and its clinical properties were compared between child (≤12 years) and juvenile (>12 years) patients. MS onset and its prevalence were assessed at the end of 2019, stratified by age range. Results. A total of 329 paediatric or juvenile patients (228 girls, 101 boys) with a clinically definite diagnosis of MS, in conformity with the 2017 McDonald Criteria, were enrolled. For 71 children (21.6%), the first symptoms appeared before the age of 12. The female: male ratio increased with age, amounting to 1:1 in the ≤12 years group and to 2.9:1 in the >12 years group. In most cases, the disease had multi-symptomatic onset (31.3%), and its course was mostly of a relapsing–remitting character (95.7%). The initial Expanded Disability Status Score for both groups was 1.63 ± 1.1, whereas the annual relapse rate was 0.84 during the first 2 years. The time between the onset of symptoms and diagnosis was longer in the younger patients (8.2 ± 4.2 vs. 4.6 ± 3.6 months; p < 0.005). On 31 December 2019, the age-adjusted prevalence standardized to the European standard population was 5.19/100,000 (95% CI, 4.64–5.78). Significantly higher prevalence was noted in the 13–18 years group (7.12; 95% CI, 6.64–7.86) than in the 9–12 years group (3.41; 95% CI, 2.98–3.86) and the <9 years group (0.56; 95% CI, 0.46–0.64; p < 0.001). Conclusion. POMS commencing at the age of ≤12 years is rare, differing significantly from the juvenile-onset and adult MS in terms of clinical characteristics, course, and incidence, as stratified by gender. |
format | Online Article Text |
id | pubmed-9785459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97854592022-12-24 The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland Brola, Waldemar Steinborn, Barbara Żak, Marek Mazurkiewicz-Bełdzińska, Maria Jóźwiak, Sergiusz Sobolewski, Piotr Wilski, Maciej Bilska, Małgorzata Siedlarska, Magdalena Puzio-Bochen, Iwona Wencel-Warot, Agnieszka Lemka, Małgorzata Kroczka, Sławomir Czyżyk, Elżbieta Bocheńska, Małgorzata Emich-Widera, Ewa Pietruszewski, Jerzy Boćkowski, Leszek Kapica-Topczewska, Katarzyna Czarnowska, Agata Kułakowska, Alina Ujma-Czapska, Barbara Gruna-Ożarowska, Agata Przysło, Łukasz Połatyńska, Katarzyna Dudzińska, Magdalena Mitosek-Szewczyk, Krystyna Melnyk, Aleksandra Adamczyk-Sowa, Monika Kotulska, Katarzyna J Clin Med Article Background. Paediatric-onset MS (POMS) has a unique clinical profile compared to the more prevalent adult-onset MS. For this study, we aimed to determine the demographic and clinical characteristics of POMS in Poland as well as addressing some of its epidemiological aspects. Methods. A retrospective study was conducted based on the Polish Multiple Sclerosis Registry, considering a population of children and adolescents with MS (age ≤ 18 years). Data were collected by all 13 centres across Poland specializing in diagnosing and treating POMS. The actual course of the disease and its clinical properties were compared between child (≤12 years) and juvenile (>12 years) patients. MS onset and its prevalence were assessed at the end of 2019, stratified by age range. Results. A total of 329 paediatric or juvenile patients (228 girls, 101 boys) with a clinically definite diagnosis of MS, in conformity with the 2017 McDonald Criteria, were enrolled. For 71 children (21.6%), the first symptoms appeared before the age of 12. The female: male ratio increased with age, amounting to 1:1 in the ≤12 years group and to 2.9:1 in the >12 years group. In most cases, the disease had multi-symptomatic onset (31.3%), and its course was mostly of a relapsing–remitting character (95.7%). The initial Expanded Disability Status Score for both groups was 1.63 ± 1.1, whereas the annual relapse rate was 0.84 during the first 2 years. The time between the onset of symptoms and diagnosis was longer in the younger patients (8.2 ± 4.2 vs. 4.6 ± 3.6 months; p < 0.005). On 31 December 2019, the age-adjusted prevalence standardized to the European standard population was 5.19/100,000 (95% CI, 4.64–5.78). Significantly higher prevalence was noted in the 13–18 years group (7.12; 95% CI, 6.64–7.86) than in the 9–12 years group (3.41; 95% CI, 2.98–3.86) and the <9 years group (0.56; 95% CI, 0.46–0.64; p < 0.001). Conclusion. POMS commencing at the age of ≤12 years is rare, differing significantly from the juvenile-onset and adult MS in terms of clinical characteristics, course, and incidence, as stratified by gender. MDPI 2022-12-17 /pmc/articles/PMC9785459/ /pubmed/36556109 http://dx.doi.org/10.3390/jcm11247494 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Brola, Waldemar Steinborn, Barbara Żak, Marek Mazurkiewicz-Bełdzińska, Maria Jóźwiak, Sergiusz Sobolewski, Piotr Wilski, Maciej Bilska, Małgorzata Siedlarska, Magdalena Puzio-Bochen, Iwona Wencel-Warot, Agnieszka Lemka, Małgorzata Kroczka, Sławomir Czyżyk, Elżbieta Bocheńska, Małgorzata Emich-Widera, Ewa Pietruszewski, Jerzy Boćkowski, Leszek Kapica-Topczewska, Katarzyna Czarnowska, Agata Kułakowska, Alina Ujma-Czapska, Barbara Gruna-Ożarowska, Agata Przysło, Łukasz Połatyńska, Katarzyna Dudzińska, Magdalena Mitosek-Szewczyk, Krystyna Melnyk, Aleksandra Adamczyk-Sowa, Monika Kotulska, Katarzyna The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
title | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
title_full | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
title_fullStr | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
title_full_unstemmed | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
title_short | The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland |
title_sort | clinical and epidemiological profile of paediatric-onset multiple sclerosis in poland |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785459/ https://www.ncbi.nlm.nih.gov/pubmed/36556109 http://dx.doi.org/10.3390/jcm11247494 |
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