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Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index

Introduction: Dietary changes play a role in metabolic response of patients with metabolic-associated fatty liver disease, and there is little evidence on the use of partial meal replacement (pMR) diets in this pathology. Aim: We decided to evaluate the modifications in transaminases levels after a...

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Autores principales: de Luis, Daniel, Primo, David, Izaola, Olatz, Lopez, Juan Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785467/
https://www.ncbi.nlm.nih.gov/pubmed/36558510
http://dx.doi.org/10.3390/nu14245353
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author de Luis, Daniel
Primo, David
Izaola, Olatz
Lopez, Juan Jose
author_facet de Luis, Daniel
Primo, David
Izaola, Olatz
Lopez, Juan Jose
author_sort de Luis, Daniel
collection PubMed
description Introduction: Dietary changes play a role in metabolic response of patients with metabolic-associated fatty liver disease, and there is little evidence on the use of partial meal replacement (pMR) diets in this pathology. Aim: We decided to evaluate the modifications in transaminases levels after a pMR hypocaloric diet in subjects with obesity and elevated fatty liver index (FLI). Material and methods: A sample of 606 patients with obesity and FLI ≥ 60 were enrolled and treated during 3 months with a pMR diet. Patients were divided as group I (Alanine amino transferase (ALT) normal) or group II (ALT ≥ 43 UI/L). Results: Body mass index, body weight, total fat mass, waist circumference, blood pressure, fasting glucose, total cholesterol, Low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, Homeostasis Model assessment (HOMA-IR), and FLI index improved significantly in the total group with pMR diet, without differences between group I and II. ALT, aspartate aminotransferase activity (AST), Gama glutamine transferase (GGT), and ratios of AST/ALT improved in both groups, too. This improvement was higher in group II (deltas group I vs. deltas group II); ALT (−4.2 ± 0.9 UI/L vs. −32.1 ± 5.7 UI/L: p = 0.01), AST (−4.8 ± 1.8 UI/L vs. −14.1 ± 1.9 UI/L: p = 0.02), GGT (−4.8 ± 1.4 UI/L vs. −37.1 ± 4.2 UI/L: p = 0.01), and AST/ALT ratio (−0.04 ± 0.002 units vs. −0.19 ± 0.04 units: p = 0.01). Conclusions: We reported that a pMR diet is an effective method to lose weight and to improve metabolic parameters in patients with obesity and high FLI. The decrease in liver parameters was greater in patients with ALT ≥ 43 UI/L.
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spelling pubmed-97854672022-12-24 Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index de Luis, Daniel Primo, David Izaola, Olatz Lopez, Juan Jose Nutrients Article Introduction: Dietary changes play a role in metabolic response of patients with metabolic-associated fatty liver disease, and there is little evidence on the use of partial meal replacement (pMR) diets in this pathology. Aim: We decided to evaluate the modifications in transaminases levels after a pMR hypocaloric diet in subjects with obesity and elevated fatty liver index (FLI). Material and methods: A sample of 606 patients with obesity and FLI ≥ 60 were enrolled and treated during 3 months with a pMR diet. Patients were divided as group I (Alanine amino transferase (ALT) normal) or group II (ALT ≥ 43 UI/L). Results: Body mass index, body weight, total fat mass, waist circumference, blood pressure, fasting glucose, total cholesterol, Low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, Homeostasis Model assessment (HOMA-IR), and FLI index improved significantly in the total group with pMR diet, without differences between group I and II. ALT, aspartate aminotransferase activity (AST), Gama glutamine transferase (GGT), and ratios of AST/ALT improved in both groups, too. This improvement was higher in group II (deltas group I vs. deltas group II); ALT (−4.2 ± 0.9 UI/L vs. −32.1 ± 5.7 UI/L: p = 0.01), AST (−4.8 ± 1.8 UI/L vs. −14.1 ± 1.9 UI/L: p = 0.02), GGT (−4.8 ± 1.4 UI/L vs. −37.1 ± 4.2 UI/L: p = 0.01), and AST/ALT ratio (−0.04 ± 0.002 units vs. −0.19 ± 0.04 units: p = 0.01). Conclusions: We reported that a pMR diet is an effective method to lose weight and to improve metabolic parameters in patients with obesity and high FLI. The decrease in liver parameters was greater in patients with ALT ≥ 43 UI/L. MDPI 2022-12-16 /pmc/articles/PMC9785467/ /pubmed/36558510 http://dx.doi.org/10.3390/nu14245353 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Luis, Daniel
Primo, David
Izaola, Olatz
Lopez, Juan Jose
Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index
title Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index
title_full Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index
title_fullStr Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index
title_full_unstemmed Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index
title_short Effects of a Short-Term Meal Replacement Hypocaloric Diet in Subjects with Obesity and High Fatty Liver Index
title_sort effects of a short-term meal replacement hypocaloric diet in subjects with obesity and high fatty liver index
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785467/
https://www.ncbi.nlm.nih.gov/pubmed/36558510
http://dx.doi.org/10.3390/nu14245353
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