Cargando…
EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation
Brassinosteroids (BRs) are a group of plant steroid hormones that play important roles in a wide range of developmental and physiological processes in plants. Transcription factors BRASSINOZALE-RESISTANT1 (BZR1) and its homologs are key components of BR signaling and integrate a wide range of intern...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785488/ https://www.ncbi.nlm.nih.gov/pubmed/36555537 http://dx.doi.org/10.3390/ijms232415889 |
_version_ | 1784858060995428352 |
---|---|
author | Zhao, Na Zhao, Min Wang, Lingyan Han, Chao Bai, Mingyi Fan, Min |
author_facet | Zhao, Na Zhao, Min Wang, Lingyan Han, Chao Bai, Mingyi Fan, Min |
author_sort | Zhao, Na |
collection | PubMed |
description | Brassinosteroids (BRs) are a group of plant steroid hormones that play important roles in a wide range of developmental and physiological processes in plants. Transcription factors BRASSINOZALE-RESISTANT1 (BZR1) and its homologs are key components of BR signaling and integrate a wide range of internal and environmental signals to coordinate plant growth and development. Although several E3 ligases have been reported to regulate the stability of BZR1, the molecular mechanism of BZR1 degradation remains unclear. Here, we reveal how a newly identified molecular mechanism underlying EBF1 directly regulates BZR1 protein stability via the 26S proteasome pathway, repressing BR function on regulating Arabidopsis apical hook development and hypocotyl elongation. BZR1 directly binds to the EBF1 gene promotor to reduce EBF1 expression. Furthermore, the genetic analysis shows that BZR1, EIN3 and PIF4 interdependently regulate plant apical hook development. Taken together, our data demonstrates that EBF1 is a negative regulator of the BR signaling pathway. |
format | Online Article Text |
id | pubmed-9785488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97854882022-12-24 EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation Zhao, Na Zhao, Min Wang, Lingyan Han, Chao Bai, Mingyi Fan, Min Int J Mol Sci Article Brassinosteroids (BRs) are a group of plant steroid hormones that play important roles in a wide range of developmental and physiological processes in plants. Transcription factors BRASSINOZALE-RESISTANT1 (BZR1) and its homologs are key components of BR signaling and integrate a wide range of internal and environmental signals to coordinate plant growth and development. Although several E3 ligases have been reported to regulate the stability of BZR1, the molecular mechanism of BZR1 degradation remains unclear. Here, we reveal how a newly identified molecular mechanism underlying EBF1 directly regulates BZR1 protein stability via the 26S proteasome pathway, repressing BR function on regulating Arabidopsis apical hook development and hypocotyl elongation. BZR1 directly binds to the EBF1 gene promotor to reduce EBF1 expression. Furthermore, the genetic analysis shows that BZR1, EIN3 and PIF4 interdependently regulate plant apical hook development. Taken together, our data demonstrates that EBF1 is a negative regulator of the BR signaling pathway. MDPI 2022-12-14 /pmc/articles/PMC9785488/ /pubmed/36555537 http://dx.doi.org/10.3390/ijms232415889 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhao, Na Zhao, Min Wang, Lingyan Han, Chao Bai, Mingyi Fan, Min EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation |
title | EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation |
title_full | EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation |
title_fullStr | EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation |
title_full_unstemmed | EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation |
title_short | EBF1 Negatively Regulates Brassinosteroid-Induced Apical Hook Development and Cell Elongation through Promoting BZR1 Degradation |
title_sort | ebf1 negatively regulates brassinosteroid-induced apical hook development and cell elongation through promoting bzr1 degradation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785488/ https://www.ncbi.nlm.nih.gov/pubmed/36555537 http://dx.doi.org/10.3390/ijms232415889 |
work_keys_str_mv | AT zhaona ebf1negativelyregulatesbrassinosteroidinducedapicalhookdevelopmentandcellelongationthroughpromotingbzr1degradation AT zhaomin ebf1negativelyregulatesbrassinosteroidinducedapicalhookdevelopmentandcellelongationthroughpromotingbzr1degradation AT wanglingyan ebf1negativelyregulatesbrassinosteroidinducedapicalhookdevelopmentandcellelongationthroughpromotingbzr1degradation AT hanchao ebf1negativelyregulatesbrassinosteroidinducedapicalhookdevelopmentandcellelongationthroughpromotingbzr1degradation AT baimingyi ebf1negativelyregulatesbrassinosteroidinducedapicalhookdevelopmentandcellelongationthroughpromotingbzr1degradation AT fanmin ebf1negativelyregulatesbrassinosteroidinducedapicalhookdevelopmentandcellelongationthroughpromotingbzr1degradation |