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Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process

Influenza virus infections and the continuing spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are global public health concerns. As there are limited therapeutic options available in clinical practice, the rapid development of safe, effective and globally available antiviral d...

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Autores principales: Huang, Yingna, Li, Yinyan, Chen, Zhixuan, Chen, Liurong, Liang, Jinlong, Zhang, Chunyu, Zhang, Zhengyin, Yang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785492/
https://www.ncbi.nlm.nih.gov/pubmed/36560742
http://dx.doi.org/10.3390/v14122738
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author Huang, Yingna
Li, Yinyan
Chen, Zhixuan
Chen, Liurong
Liang, Jinlong
Zhang, Chunyu
Zhang, Zhengyin
Yang, Jie
author_facet Huang, Yingna
Li, Yinyan
Chen, Zhixuan
Chen, Liurong
Liang, Jinlong
Zhang, Chunyu
Zhang, Zhengyin
Yang, Jie
author_sort Huang, Yingna
collection PubMed
description Influenza virus infections and the continuing spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are global public health concerns. As there are limited therapeutic options available in clinical practice, the rapid development of safe, effective and globally available antiviral drugs is crucial. Drug repurposing is a therapeutic strategy used in treatments for newly emerging and re-emerging infectious diseases. It has recently been shown that the voltage-dependent Ca(2+) channel Cav1.2 is critical for influenza A virus entry, providing a potential target for antiviral strategies. Nisoldipine, a selective Ca(2+) channel inhibitor, is commonly used in the treatment of hypertension. Here, we assessed the antiviral potential of nisoldipine against the influenza A virus and explored the mechanism of action of this compound. We found that nisoldipine treatment could potently inhibit infection with multiple influenza A virus strains. Mechanistic studies further revealed that nisoldipine impaired the internalization of the influenza virus into host cells. Overall, our findings demonstrate that nisoldipine exerts antiviral effects against influenza A virus infection and could serve as a lead compound in the design and development of new antivirals.
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spelling pubmed-97854922022-12-24 Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process Huang, Yingna Li, Yinyan Chen, Zhixuan Chen, Liurong Liang, Jinlong Zhang, Chunyu Zhang, Zhengyin Yang, Jie Viruses Article Influenza virus infections and the continuing spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are global public health concerns. As there are limited therapeutic options available in clinical practice, the rapid development of safe, effective and globally available antiviral drugs is crucial. Drug repurposing is a therapeutic strategy used in treatments for newly emerging and re-emerging infectious diseases. It has recently been shown that the voltage-dependent Ca(2+) channel Cav1.2 is critical for influenza A virus entry, providing a potential target for antiviral strategies. Nisoldipine, a selective Ca(2+) channel inhibitor, is commonly used in the treatment of hypertension. Here, we assessed the antiviral potential of nisoldipine against the influenza A virus and explored the mechanism of action of this compound. We found that nisoldipine treatment could potently inhibit infection with multiple influenza A virus strains. Mechanistic studies further revealed that nisoldipine impaired the internalization of the influenza virus into host cells. Overall, our findings demonstrate that nisoldipine exerts antiviral effects against influenza A virus infection and could serve as a lead compound in the design and development of new antivirals. MDPI 2022-12-08 /pmc/articles/PMC9785492/ /pubmed/36560742 http://dx.doi.org/10.3390/v14122738 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Yingna
Li, Yinyan
Chen, Zhixuan
Chen, Liurong
Liang, Jinlong
Zhang, Chunyu
Zhang, Zhengyin
Yang, Jie
Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process
title Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process
title_full Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process
title_fullStr Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process
title_full_unstemmed Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process
title_short Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process
title_sort nisoldipine inhibits influenza a virus infection by interfering with virus internalization process
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785492/
https://www.ncbi.nlm.nih.gov/pubmed/36560742
http://dx.doi.org/10.3390/v14122738
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