Cargando…

Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma

Background: Malignant pleural mesothelioma (MPM) is an aggressive and rare malignant pleural tumor. Methods: MPM patients diagnosed in Beijing Chaoyang Hospital and Beijing Tongren Hospital were the focus of this study. We collected and analyzed the histological, radiological, and metabolic features...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yuan, Li, Ran, Gu, Yumei, LiZhu, Yuerong, Liu, Xiaofang, Zhang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785569/
https://www.ncbi.nlm.nih.gov/pubmed/36557076
http://dx.doi.org/10.3390/medicina58121874
_version_ 1784858080818757632
author Zhang, Yuan
Li, Ran
Gu, Yumei
LiZhu, Yuerong
Liu, Xiaofang
Zhang, Shu
author_facet Zhang, Yuan
Li, Ran
Gu, Yumei
LiZhu, Yuerong
Liu, Xiaofang
Zhang, Shu
author_sort Zhang, Yuan
collection PubMed
description Background: Malignant pleural mesothelioma (MPM) is an aggressive and rare malignant pleural tumor. Methods: MPM patients diagnosed in Beijing Chaoyang Hospital and Beijing Tongren Hospital were the focus of this study. We collected and analyzed the histological, radiological, and metabolic features of MPM patients. At the same time, Cox univariable and multivariable analyses were used to explore the laboratory risk factors affecting the prognosis of MPM patients. Results: A total of 129 MPM patients were included in this study. MPM includes three main histological subtypes: epithelioid, sarcomatoid and biphasic. Among them, epithelial subtypes accounted for the highest proportion. Calretinin, Wilms’ tumor gene (WT1), cytokeratin 5/6 (CK5/6), and D2-40 were the most useful mesothelial markers to support a MPM diagnosis. The imaging features of MPM patients are pleural thickening and pleural effusion. In PET-CT, the affected pleura showed obvious high uptake of tracer, and the degree was related to the specific subtype. The median follow-up time was 55.0 (30.0, 94.0) months. A total of 92 (71.3%) patients died during follow-up. The median survival time of patients was 21.0 (9.0, 48.0) months. The Cox multivariable analysis showed that age [hazard ratio (HR), 1.824; 95% confidence interval (CI) 1.159–2.872; p = 0.009; uncorrected], ESR (HR, 2.197; 95% CI 1.318–3.664; p = 0.003; with Bonferroni correction), lymphocytes (HR, 0.436; 95% CI 0.258–0.737; p = 0.002; with Bonferroni correction), platelets (HR, 1.802; 95% CI 1.084–2.997; p = 0.023; uncorrected) and total protein (HR, 0.625; 95% CI 0.394–0.990; p = 0.045; uncorrected) were independent risk factors for prognosis, after adjusting for confounding factors. Conclusions: Age, ESR, lymphocytes, platelets and total protein may be related to the prognosis of MPM patients. Summarizing the histological, radiological, and metabolic features of MPM patients in the two centers can increase clinicians’ understanding of this rare tumor.
format Online
Article
Text
id pubmed-9785569
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97855692022-12-24 Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma Zhang, Yuan Li, Ran Gu, Yumei LiZhu, Yuerong Liu, Xiaofang Zhang, Shu Medicina (Kaunas) Article Background: Malignant pleural mesothelioma (MPM) is an aggressive and rare malignant pleural tumor. Methods: MPM patients diagnosed in Beijing Chaoyang Hospital and Beijing Tongren Hospital were the focus of this study. We collected and analyzed the histological, radiological, and metabolic features of MPM patients. At the same time, Cox univariable and multivariable analyses were used to explore the laboratory risk factors affecting the prognosis of MPM patients. Results: A total of 129 MPM patients were included in this study. MPM includes three main histological subtypes: epithelioid, sarcomatoid and biphasic. Among them, epithelial subtypes accounted for the highest proportion. Calretinin, Wilms’ tumor gene (WT1), cytokeratin 5/6 (CK5/6), and D2-40 were the most useful mesothelial markers to support a MPM diagnosis. The imaging features of MPM patients are pleural thickening and pleural effusion. In PET-CT, the affected pleura showed obvious high uptake of tracer, and the degree was related to the specific subtype. The median follow-up time was 55.0 (30.0, 94.0) months. A total of 92 (71.3%) patients died during follow-up. The median survival time of patients was 21.0 (9.0, 48.0) months. The Cox multivariable analysis showed that age [hazard ratio (HR), 1.824; 95% confidence interval (CI) 1.159–2.872; p = 0.009; uncorrected], ESR (HR, 2.197; 95% CI 1.318–3.664; p = 0.003; with Bonferroni correction), lymphocytes (HR, 0.436; 95% CI 0.258–0.737; p = 0.002; with Bonferroni correction), platelets (HR, 1.802; 95% CI 1.084–2.997; p = 0.023; uncorrected) and total protein (HR, 0.625; 95% CI 0.394–0.990; p = 0.045; uncorrected) were independent risk factors for prognosis, after adjusting for confounding factors. Conclusions: Age, ESR, lymphocytes, platelets and total protein may be related to the prognosis of MPM patients. Summarizing the histological, radiological, and metabolic features of MPM patients in the two centers can increase clinicians’ understanding of this rare tumor. MDPI 2022-12-19 /pmc/articles/PMC9785569/ /pubmed/36557076 http://dx.doi.org/10.3390/medicina58121874 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yuan
Li, Ran
Gu, Yumei
LiZhu, Yuerong
Liu, Xiaofang
Zhang, Shu
Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma
title Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma
title_full Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma
title_fullStr Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma
title_full_unstemmed Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma
title_short Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma
title_sort clinical, laboratory, histological, radiological, and metabolic features and prognosis of malignant pleural mesothelioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785569/
https://www.ncbi.nlm.nih.gov/pubmed/36557076
http://dx.doi.org/10.3390/medicina58121874
work_keys_str_mv AT zhangyuan clinicallaboratoryhistologicalradiologicalandmetabolicfeaturesandprognosisofmalignantpleuralmesothelioma
AT liran clinicallaboratoryhistologicalradiologicalandmetabolicfeaturesandprognosisofmalignantpleuralmesothelioma
AT guyumei clinicallaboratoryhistologicalradiologicalandmetabolicfeaturesandprognosisofmalignantpleuralmesothelioma
AT lizhuyuerong clinicallaboratoryhistologicalradiologicalandmetabolicfeaturesandprognosisofmalignantpleuralmesothelioma
AT liuxiaofang clinicallaboratoryhistologicalradiologicalandmetabolicfeaturesandprognosisofmalignantpleuralmesothelioma
AT zhangshu clinicallaboratoryhistologicalradiologicalandmetabolicfeaturesandprognosisofmalignantpleuralmesothelioma