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Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot

Background and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to improve early diagnosis and management of DF. Mater...

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Autores principales: Vujčić, Sanja, Kotur-Stevuljević, Jelena, Vekić, Jelena, Perović-Blagojević, Iva, Stefanović, Tatjana, Ilić-Mijailović, Sanja, Koprivica Uzelac, Branka, Bosić, Srećko, Antonić, Tamara, Guzonjić, Azra, Mastilović, Ana-Marija, Marković, Zorica, Rizzo, Manfredi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785583/
https://www.ncbi.nlm.nih.gov/pubmed/36557068
http://dx.doi.org/10.3390/medicina58121866
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author Vujčić, Sanja
Kotur-Stevuljević, Jelena
Vekić, Jelena
Perović-Blagojević, Iva
Stefanović, Tatjana
Ilić-Mijailović, Sanja
Koprivica Uzelac, Branka
Bosić, Srećko
Antonić, Tamara
Guzonjić, Azra
Mastilović, Ana-Marija
Marković, Zorica
Rizzo, Manfredi
author_facet Vujčić, Sanja
Kotur-Stevuljević, Jelena
Vekić, Jelena
Perović-Blagojević, Iva
Stefanović, Tatjana
Ilić-Mijailović, Sanja
Koprivica Uzelac, Branka
Bosić, Srećko
Antonić, Tamara
Guzonjić, Azra
Mastilović, Ana-Marija
Marković, Zorica
Rizzo, Manfredi
author_sort Vujčić, Sanja
collection PubMed
description Background and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to improve early diagnosis and management of DF. Materials and Methods: The prooxidant–antioxidant balance (PAB), superoxide dismutase (SOD), total oxidative status (TOS), total sulfhydryl groups (SHG), routine biochemical parameters, and complete blood count were determined in 42 patients with type-2 DM, of which 23 patients had DF, while 19 patients were without DF complications. The neutrophils-to-lymphocyte ratio (NLR) was evaluated as a biomarker of inflammation. Results: Patients with DF had significantly higher (p < 0.05) PAB levels (170 ± 33.9 U/L) compared to those without DF complications (142 ± 31.3 U/L). In addition, patients with DF had significantly reduced SOD activities (p < 0.01). NLR values were significantly higher in the DF group (median: 2.8; interquartile range: 2.0–4.3) than in the group without DF (median: 1.4; interquartile range: 1.4–2.1; p < 0.01). A positive correlation was found between the PAB and NLR index (r = 0.449; p < 0.05). The diagnostic accuracy of both PAB (AUC = 0.741; p < 0.01) and NLR (AUC = 0.760; p < 0.01) was estimated as acceptable. Conclusions: In conclusion, the development of DF is associated with enhanced OS and inflammation processes. PAB and NLR could be useful non-invasive biomarkers of DF development.
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spelling pubmed-97855832022-12-24 Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot Vujčić, Sanja Kotur-Stevuljević, Jelena Vekić, Jelena Perović-Blagojević, Iva Stefanović, Tatjana Ilić-Mijailović, Sanja Koprivica Uzelac, Branka Bosić, Srećko Antonić, Tamara Guzonjić, Azra Mastilović, Ana-Marija Marković, Zorica Rizzo, Manfredi Medicina (Kaunas) Article Background and Objectives: Diabetic foot (DF) development is driven by complex interactions of hyperglycemia, inflammation, and oxidative stress (OS). We aimed to investigate OS and inflammatory biomarkers in patients with DF and their potential to improve early diagnosis and management of DF. Materials and Methods: The prooxidant–antioxidant balance (PAB), superoxide dismutase (SOD), total oxidative status (TOS), total sulfhydryl groups (SHG), routine biochemical parameters, and complete blood count were determined in 42 patients with type-2 DM, of which 23 patients had DF, while 19 patients were without DF complications. The neutrophils-to-lymphocyte ratio (NLR) was evaluated as a biomarker of inflammation. Results: Patients with DF had significantly higher (p < 0.05) PAB levels (170 ± 33.9 U/L) compared to those without DF complications (142 ± 31.3 U/L). In addition, patients with DF had significantly reduced SOD activities (p < 0.01). NLR values were significantly higher in the DF group (median: 2.8; interquartile range: 2.0–4.3) than in the group without DF (median: 1.4; interquartile range: 1.4–2.1; p < 0.01). A positive correlation was found between the PAB and NLR index (r = 0.449; p < 0.05). The diagnostic accuracy of both PAB (AUC = 0.741; p < 0.01) and NLR (AUC = 0.760; p < 0.01) was estimated as acceptable. Conclusions: In conclusion, the development of DF is associated with enhanced OS and inflammation processes. PAB and NLR could be useful non-invasive biomarkers of DF development. MDPI 2022-12-17 /pmc/articles/PMC9785583/ /pubmed/36557068 http://dx.doi.org/10.3390/medicina58121866 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vujčić, Sanja
Kotur-Stevuljević, Jelena
Vekić, Jelena
Perović-Blagojević, Iva
Stefanović, Tatjana
Ilić-Mijailović, Sanja
Koprivica Uzelac, Branka
Bosić, Srećko
Antonić, Tamara
Guzonjić, Azra
Mastilović, Ana-Marija
Marković, Zorica
Rizzo, Manfredi
Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
title Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
title_full Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
title_fullStr Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
title_full_unstemmed Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
title_short Oxidative Stress and Inflammatory Biomarkers in Patients with Diabetic Foot
title_sort oxidative stress and inflammatory biomarkers in patients with diabetic foot
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785583/
https://www.ncbi.nlm.nih.gov/pubmed/36557068
http://dx.doi.org/10.3390/medicina58121866
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