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Granulicatella spp., a Causative Agent of Infective Endocarditis in Children

Granulicatella spp. are non-motile, non-sporulating, facultatively anaerobic Gram-positive cocci. Throughout the literature, these organisms have been referred to by several names, such as “nutritionally deficient streptococci”, “vitamin-B dependent streptococci” and “pyridoxal-dependent streptococc...

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Autores principales: Albano, Chiara, Bagarello, Sara, Giordano, Salvatore, Sanfilippo, Maria Fiorella, Comparato, Calogero, Scardino, Giuseppe, Garbo, Valeria, Boncori, Giovanni, Condemi, Anna, Cascio, Antonio, Colomba, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785600/
https://www.ncbi.nlm.nih.gov/pubmed/36558764
http://dx.doi.org/10.3390/pathogens11121431
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author Albano, Chiara
Bagarello, Sara
Giordano, Salvatore
Sanfilippo, Maria Fiorella
Comparato, Calogero
Scardino, Giuseppe
Garbo, Valeria
Boncori, Giovanni
Condemi, Anna
Cascio, Antonio
Colomba, Claudia
author_facet Albano, Chiara
Bagarello, Sara
Giordano, Salvatore
Sanfilippo, Maria Fiorella
Comparato, Calogero
Scardino, Giuseppe
Garbo, Valeria
Boncori, Giovanni
Condemi, Anna
Cascio, Antonio
Colomba, Claudia
author_sort Albano, Chiara
collection PubMed
description Granulicatella spp. are non-motile, non-sporulating, facultatively anaerobic Gram-positive cocci. Throughout the literature, these organisms have been referred to by several names, such as “nutritionally deficient streptococci”, “vitamin-B dependent streptococci” and “pyridoxal-dependent streptococci”, because of their fastidious nutritional requirements, which can often make culture isolation challenging. Known to be a member of the normal microbiota of the human oral cavity and urogenital and intestinal tracts, similar to other streptococci, Granulicatella spp. can cause bacteremia, sepsis and infective endocarditis. Considering the difficulty in growing this organism on culture medium, the fact that it is now included among the bacteria known to be responsible for culture-negative infective endocarditis suggests that its pathogenic role could be highly underestimated. Moreover, being considered such a rare causative agent, it is not a target of standard antibiotic empiric treatment. We present a rare case of G. elegans endocarditis in a young child and review the medical literature on Granulicatella endocarditis in the pediatric population, with the aim of sharing knowledge about this microorganism, which can be challenging for a clinician who is not familiar with it.
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spelling pubmed-97856002022-12-24 Granulicatella spp., a Causative Agent of Infective Endocarditis in Children Albano, Chiara Bagarello, Sara Giordano, Salvatore Sanfilippo, Maria Fiorella Comparato, Calogero Scardino, Giuseppe Garbo, Valeria Boncori, Giovanni Condemi, Anna Cascio, Antonio Colomba, Claudia Pathogens Review Granulicatella spp. are non-motile, non-sporulating, facultatively anaerobic Gram-positive cocci. Throughout the literature, these organisms have been referred to by several names, such as “nutritionally deficient streptococci”, “vitamin-B dependent streptococci” and “pyridoxal-dependent streptococci”, because of their fastidious nutritional requirements, which can often make culture isolation challenging. Known to be a member of the normal microbiota of the human oral cavity and urogenital and intestinal tracts, similar to other streptococci, Granulicatella spp. can cause bacteremia, sepsis and infective endocarditis. Considering the difficulty in growing this organism on culture medium, the fact that it is now included among the bacteria known to be responsible for culture-negative infective endocarditis suggests that its pathogenic role could be highly underestimated. Moreover, being considered such a rare causative agent, it is not a target of standard antibiotic empiric treatment. We present a rare case of G. elegans endocarditis in a young child and review the medical literature on Granulicatella endocarditis in the pediatric population, with the aim of sharing knowledge about this microorganism, which can be challenging for a clinician who is not familiar with it. MDPI 2022-11-28 /pmc/articles/PMC9785600/ /pubmed/36558764 http://dx.doi.org/10.3390/pathogens11121431 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Albano, Chiara
Bagarello, Sara
Giordano, Salvatore
Sanfilippo, Maria Fiorella
Comparato, Calogero
Scardino, Giuseppe
Garbo, Valeria
Boncori, Giovanni
Condemi, Anna
Cascio, Antonio
Colomba, Claudia
Granulicatella spp., a Causative Agent of Infective Endocarditis in Children
title Granulicatella spp., a Causative Agent of Infective Endocarditis in Children
title_full Granulicatella spp., a Causative Agent of Infective Endocarditis in Children
title_fullStr Granulicatella spp., a Causative Agent of Infective Endocarditis in Children
title_full_unstemmed Granulicatella spp., a Causative Agent of Infective Endocarditis in Children
title_short Granulicatella spp., a Causative Agent of Infective Endocarditis in Children
title_sort granulicatella spp., a causative agent of infective endocarditis in children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785600/
https://www.ncbi.nlm.nih.gov/pubmed/36558764
http://dx.doi.org/10.3390/pathogens11121431
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