Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. Th...

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Autores principales: Vancura, Adrienne, Gutierrez, Alejandro H., Hennig, Thorben, Pulido-Quetglas, Carlos, Slack, Frank J., Johnson, Rory, Haefliger, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785742/
https://www.ncbi.nlm.nih.gov/pubmed/36548181
http://dx.doi.org/10.3390/ncrna8060082
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author Vancura, Adrienne
Gutierrez, Alejandro H.
Hennig, Thorben
Pulido-Quetglas, Carlos
Slack, Frank J.
Johnson, Rory
Haefliger, Simon
author_facet Vancura, Adrienne
Gutierrez, Alejandro H.
Hennig, Thorben
Pulido-Quetglas, Carlos
Slack, Frank J.
Johnson, Rory
Haefliger, Simon
author_sort Vancura, Adrienne
collection PubMed
description Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in the selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for the prioritisation of cancer-related lncRNAs.
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spelling pubmed-97857422022-12-24 Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3 Vancura, Adrienne Gutierrez, Alejandro H. Hennig, Thorben Pulido-Quetglas, Carlos Slack, Frank J. Johnson, Rory Haefliger, Simon Noncoding RNA Brief Report Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in the selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for the prioritisation of cancer-related lncRNAs. MDPI 2022-12-07 /pmc/articles/PMC9785742/ /pubmed/36548181 http://dx.doi.org/10.3390/ncrna8060082 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Vancura, Adrienne
Gutierrez, Alejandro H.
Hennig, Thorben
Pulido-Quetglas, Carlos
Slack, Frank J.
Johnson, Rory
Haefliger, Simon
Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3
title Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3
title_full Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3
title_fullStr Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3
title_full_unstemmed Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3
title_short Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3
title_sort is evolutionary conservation a useful predictor for cancer long noncoding rnas? insights from the cancer lncrna census 3
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785742/
https://www.ncbi.nlm.nih.gov/pubmed/36548181
http://dx.doi.org/10.3390/ncrna8060082
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