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The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases
Polyphenols are secondary metabolites of plants and play a potential role in the prevention and treatment of neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to their unique physiological functions such as acting as antioxidants, being anti-inflammat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785743/ https://www.ncbi.nlm.nih.gov/pubmed/36558531 http://dx.doi.org/10.3390/nu14245373 |
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author | Zhang, Yuan Yu, Wanpeng Zhang, Lei Wang, Man Chang, Wenguang |
author_facet | Zhang, Yuan Yu, Wanpeng Zhang, Lei Wang, Man Chang, Wenguang |
author_sort | Zhang, Yuan |
collection | PubMed |
description | Polyphenols are secondary metabolites of plants and play a potential role in the prevention and treatment of neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to their unique physiological functions such as acting as antioxidants, being anti-inflammatory, being neuroprotective, and promoting intestinal health. Since dietary polyphenols exist in plant foods in the form of glycosylation or esterification or are combined with polymers, they need to undergo extensive metabolism through phase I and phase II biotransformations by various intestinal enzymes, as well as metabolism by the intestinal microbiota before they can be fully absorbed. Polyphenols improve intestinal microbiota disorders by influencing the structure and function of intestinal microbiota, inducing beneficial bacteria to produce a variety of metabolites such as short-chain fatty acids (SCFAs), promoting the secretion of hormones and neurotransmitters, and playing an important role in the prevention and treatment of NND by affecting the microbe–gut–brain axis. We review the ways in which some polyphenols can change the composition of the intestinal microbiota and their metabolites in AD or PD animal models to exert the role of slowing down the progression of NND, aiming to provide evidence for the role of polyphenols in slowing the progression of NND via the microbiota–gut–brain (MGB) axis. |
format | Online Article Text |
id | pubmed-9785743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97857432022-12-24 The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases Zhang, Yuan Yu, Wanpeng Zhang, Lei Wang, Man Chang, Wenguang Nutrients Review Polyphenols are secondary metabolites of plants and play a potential role in the prevention and treatment of neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to their unique physiological functions such as acting as antioxidants, being anti-inflammatory, being neuroprotective, and promoting intestinal health. Since dietary polyphenols exist in plant foods in the form of glycosylation or esterification or are combined with polymers, they need to undergo extensive metabolism through phase I and phase II biotransformations by various intestinal enzymes, as well as metabolism by the intestinal microbiota before they can be fully absorbed. Polyphenols improve intestinal microbiota disorders by influencing the structure and function of intestinal microbiota, inducing beneficial bacteria to produce a variety of metabolites such as short-chain fatty acids (SCFAs), promoting the secretion of hormones and neurotransmitters, and playing an important role in the prevention and treatment of NND by affecting the microbe–gut–brain axis. We review the ways in which some polyphenols can change the composition of the intestinal microbiota and their metabolites in AD or PD animal models to exert the role of slowing down the progression of NND, aiming to provide evidence for the role of polyphenols in slowing the progression of NND via the microbiota–gut–brain (MGB) axis. MDPI 2022-12-17 /pmc/articles/PMC9785743/ /pubmed/36558531 http://dx.doi.org/10.3390/nu14245373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Yuan Yu, Wanpeng Zhang, Lei Wang, Man Chang, Wenguang The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases |
title | The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases |
title_full | The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases |
title_fullStr | The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases |
title_full_unstemmed | The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases |
title_short | The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases |
title_sort | interaction of polyphenols and the gut microbiota in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785743/ https://www.ncbi.nlm.nih.gov/pubmed/36558531 http://dx.doi.org/10.3390/nu14245373 |
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