Cargando…

S-Benproperine, an Active Stereoisomer of Benproperine, Suppresses Cancer Migration and Tumor Metastasis by Targeting ARPC2

Metastasis, in which cancer cells migrate to other tissues and form new tumors, is a major cause of both cancer death and treatment failure. In a previous study, benproperine (Benp) was identified as a cancer cell migration inhibitor and an inhibitor of actin-related protein 2/3 complex subunit 2 (A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Hyun-Jin, Yoon, Yae Jin, Choi, Jiyeon, Lee, Yu-Jin, Lee, Sangku, Cho, Wansang, Byun, Wan Gi, Park, Seung Bum, Han, Dong Cho, Kwon, Byoung-Mog
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785746/ https://www.ncbi.nlm.nih.gov/pubmed/36558913 http://dx.doi.org/10.3390/ph15121462

Ejemplares similares

Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest
por: Zhang, Huanyu, et al.
Publicado: (2020)

Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex
por: Choi, Jiyeon, et al.
Publicado: (2019)

2′‐Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation
por: Yoon, Yae Jin, et al.
Publicado: (2018)

ARPC2 promotes breast cancer proliferation and metastasis
por: Cheng, Zhongle, et al.
Publicado: (2019)

Acacetin Inhibits the Growth of STAT3-Activated DU145 Prostate Cancer Cells by Directly Binding to Signal Transducer and Activator of Transcription 3 (STAT3)
por: Yun, Sun, et al.
Publicado: (2021)

Ginkgetin inhibits the growth of DU−145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
por: Jeon, Yoon Jung, et al.
Publicado: (2015)

ARPC1B Mutation Manifesting as Recurrent Hematemesis With Metaplasia
por: Antala, Swati, et al.
Publicado: (2021)

Role of ARPC2 in Human Gastric Cancer
por: Zhang, Jun, et al.
Publicado: (2017)

Effect of stereoisomers related to ICRF-159 on metastasis of B16 melanoma.
por: Zwilling, B. S., et al.
Publicado: (1981)

Directed Biosynthesis of Mitragynine Stereoisomers
por: Schotte, Carsten, et al.
Publicado: (2023)

Defective Neutrophil Transendothelial Migration and Lateral Motility in ARPC1B Deficiency Under Flow Conditions
por: Kempers, Lanette, et al.
Publicado: (2021)

Stereoisomer-Independent Stable Blue Emission in Axial Chiral Difluorenol
por: Yu, Mengna, et al.
Publicado: (2021)

ARPC1B Is Associated with Lethal Prostate Cancer and Its Inhibition Decreases Cell Invasion and Migration In Vitro
por: Gamallat, Yaser, et al.
Publicado: (2022)

ARPC5 acts as a potential prognostic biomarker that is associated with cell proliferation, migration and immune infiltrate in gliomas
por: Ming, Yue, et al.
Publicado: (2023)

Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers
por: Salgado, Paula Regina Rodrigues, et al.
Publicado: (2015)

CRISPR-Cas9 Arabidopsis mutants of genes for ARPC1 and ARPC3 subunits of ARP2/3 complex reveal differential roles of complex subunits
por: Bellinvia, Erica, et al.
Publicado: (2022)

Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
por: Kim, Jonghoon, et al.
Publicado: (2016)

Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
por: Yang, Kyeong-Eun, et al.
Publicado: (2020)

ARPC1A correlates with poor prognosis in prostate cancer and is up-regulated by glutamine metabolism to promote tumor cell migration, invasion and cytoskeletal changes
por: Chen, Ye-Hui, et al.
Publicado: (2023)

Author Correction: CRISPR‑Cas9 Arabidopsis mutants of genes for ARPC1 and ARPC3 subunits of ARP2/3 complex reveal differential roles of complex subunits
por: Bellinvia, Erica, et al.
Publicado: (2023)

Chemoenzymatic Synthesis of the Most Pleasant Stereoisomer of Jessemal
por: Venturi, Silvia, et al.
Publicado: (2022)

Stereoisomer-dependent conversion of dinaphthothienothiophene precursor films
por: Shioya, Nobutaka, et al.
Publicado: (2022)

Differential Activation of TRPM8 by the Stereoisomers of Menthol
por: Chen, Xiaoying, et al.
Publicado: (2022)

Binary fluorous tagging enables the synthesis and separation of a sixteen-stereoisomer library of macrosphelides
por: Curran, Dennis P., et al.
Publicado: (2012)

A controlled random gene perturbation method identifies ARPC1B gene as a key regulator of cancer metastasis
por: Chang, De, et al.
Publicado: (2022)

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers
por: Brem, Jürgen, et al.
Publicado: (2015)

TaARPC3, Contributes to Wheat Resistance against the Stripe Rust Fungus
por: Qi, Tuo, et al.
Publicado: (2017)

Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
por: Randzavola, Lyra O., et al.
Publicado: (2019)

ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality
por: Sindram, Elena, et al.
Publicado: (2023)

Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling
por: Nunes-Santos, Cristiane J., et al.
Publicado: (2023)

Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression
por: Xu, Wujian, et al.
Publicado: (2011)

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review
por: Peng, Ming, et al.
Publicado: (2018)

Conformations of cyclopentasilane stereoisomers control molecular junction conductance
por: Li, Haixing, et al.
Publicado: (2016)

Stereoselective Syntheses of all the Possible Stereoisomers of Coronafacic Acid
por: Watanabe, Raku, et al.
Publicado: (2020)

Astaxanthin Bioactivity Is Determined by Stereoisomer Composition and Extraction Method
por: Snell, Terry W., et al.
Publicado: (2022)

Ginsenoside Rg3 stereoisomers differentially inhibit vascular smooth muscle cell proliferation and migration in diabetic atherosclerosis
por: Guo, Mengqi, et al.
Publicado: (2018)

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A
por: Molli, Poonam R., et al.
Publicado: (2010)

DHX36, BAX, and ARPC1B May Be Critical for the Diagnosis and Treatment of Tuberculosis
por: Zhang, Yunli, et al.
Publicado: (2020)

Radiosensitivity in patients affected by ARPC1B deficiency: a new disease trait?
por: Chiriaco, Maria, et al.
Publicado: (2022)

Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis
por: Zhang, Ruzhen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_q4483isjala6pllnfnt5k7bemc