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Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review
Vaccines against SARS-CoV-2 have saved millions of lives and played an important role in containing the COVID-19 pandemic. Vaccination against SARS-CoV-2 is also associated with reduced disease severity and, perhaps, with COVID-19 symptom burden. In this narrative review, we present, in a clinically...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785763/ https://www.ncbi.nlm.nih.gov/pubmed/36556422 http://dx.doi.org/10.3390/life12122057 |
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author | Tofarides, Andreas G. Christaki, Eirini Milionis, Haralampos Nikolopoulos, Georgios K. |
author_facet | Tofarides, Andreas G. Christaki, Eirini Milionis, Haralampos Nikolopoulos, Georgios K. |
author_sort | Tofarides, Andreas G. |
collection | PubMed |
description | Vaccines against SARS-CoV-2 have saved millions of lives and played an important role in containing the COVID-19 pandemic. Vaccination against SARS-CoV-2 is also associated with reduced disease severity and, perhaps, with COVID-19 symptom burden. In this narrative review, we present, in a clinically relevant question-and-answer manner, the evidence regarding the association between vaccination against SARS-CoV-2 and long COVID-19. We discuss how the mechanism of action of vaccines could interplay with the pathophysiology of post-COVID-19 condition. Furthermore, we describe how specific factors, such as the number of vaccine doses and the type of SARS-CoV-2 variants, may affect post-COVID-19 condition. We also discuss the role of timing for vaccination in relation to the onset of long COVID-19 symptoms, as it seems to affect the frequency and severity of the condition. Additionally, we describe the potential modifying effect of age, as well as the association of type and level of immune response with long COVID-19. We also describe how system-specific long COVID-19 sequelae, namely neurocognitive-psychologic symptoms and cardiovascular pathology, could be altered by vaccination. Last, we address the question of whether seasonal influenza vaccination has a meaningful impact on the frequency of long COVID-19. |
format | Online Article Text |
id | pubmed-9785763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97857632022-12-24 Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review Tofarides, Andreas G. Christaki, Eirini Milionis, Haralampos Nikolopoulos, Georgios K. Life (Basel) Review Vaccines against SARS-CoV-2 have saved millions of lives and played an important role in containing the COVID-19 pandemic. Vaccination against SARS-CoV-2 is also associated with reduced disease severity and, perhaps, with COVID-19 symptom burden. In this narrative review, we present, in a clinically relevant question-and-answer manner, the evidence regarding the association between vaccination against SARS-CoV-2 and long COVID-19. We discuss how the mechanism of action of vaccines could interplay with the pathophysiology of post-COVID-19 condition. Furthermore, we describe how specific factors, such as the number of vaccine doses and the type of SARS-CoV-2 variants, may affect post-COVID-19 condition. We also discuss the role of timing for vaccination in relation to the onset of long COVID-19 symptoms, as it seems to affect the frequency and severity of the condition. Additionally, we describe the potential modifying effect of age, as well as the association of type and level of immune response with long COVID-19. We also describe how system-specific long COVID-19 sequelae, namely neurocognitive-psychologic symptoms and cardiovascular pathology, could be altered by vaccination. Last, we address the question of whether seasonal influenza vaccination has a meaningful impact on the frequency of long COVID-19. MDPI 2022-12-08 /pmc/articles/PMC9785763/ /pubmed/36556422 http://dx.doi.org/10.3390/life12122057 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tofarides, Andreas G. Christaki, Eirini Milionis, Haralampos Nikolopoulos, Georgios K. Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review |
title | Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review |
title_full | Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review |
title_fullStr | Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review |
title_full_unstemmed | Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review |
title_short | Effect of Vaccination against SARS-CoV-2 on Long COVID-19: A Narrative Review |
title_sort | effect of vaccination against sars-cov-2 on long covid-19: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785763/ https://www.ncbi.nlm.nih.gov/pubmed/36556422 http://dx.doi.org/10.3390/life12122057 |
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